Department of Biology

Active

Anti-cancer effects of Artemisia vulgaris and Artemisia glauca against glioblastoma in Kazakhstan

Akbay, B. (PI)

3/1/25 → 12/31/27

Project: Government

Multisensory influences on thalamic theta oscillations during spatial navigation

Pak (Staff), A. (PI)

3/1/25 → 12/31/27

Project: Government

Investigating nutrient remobilization during heat and UV stress induced senescence in Arabidopsis and barley for enhanced crop resilience and nutritional quality

Soltabayeva, A. (PI)

3/1/25 → 12/31/27

Project: Government

Identification and functional characterization of novel genetic mutations causing dilated cardiomyopathy in patients of Kazakhstan

Akilzhanova, A. (PI), Sarbassov, D. (Co-PI), Abdrakhmanov, A. (Co-PI), Loeys, B. (Other participant), Karazhanova, L. (Other participant), Bekbossynova, M. (Other Faculty/Researcher), Kairov, U. (Other Faculty/Researcher) & Rakhimova, S. (Other Faculty/Researcher)

1/1/24 → 12/31/26

Project: CRP

The role of B1 B cells in neurologic disorders

Ponomarev, E. (PI), Vorobyev, I. (Co-PI), Barteneva, N. (Other Faculty/Researcher), Tsoy, A. (Co-PI) & Yung, W.-H. (Other Faculty/Researcher)

1/1/24 → 12/31/26

Project: FDCRGP

RKSLEC: Responses of Kazakhstan Saline Lakes to Environmental Changes

Barteneva, N. (PI)

1/1/24 → 12/31/26

Project: FDCRGP

Investigation of lactoferrin-mediated enhancement of cathepsin G activity and immune evasion mechanisms of tumor cells

Burster, T. (PI), Kalendar, R. (Co-PI) & Bissenbaev, A. (Co-PI)

1/1/23 → 12/31/25

Project: CRP

Phytochemical Profiles and Neuroprotective, Anti-epileptogenic Activities of Artemisia glauca and Artemisia vulgaris from Kazakhstan.

Tokay, T. (PI), Tsoy, A. (Co-PI) & Suleimen, Y. (Co-PI)

1/1/23 → 12/31/25

Project: CRP

AP19676488: Identification of new genetic variants associated with the development of diabetic kidney disease by whole exome sequencing

Sarria-Santamera, A. (PI), Atageldiyeva, K. (Other Faculty/Researcher), Gaipov, A. (Other Faculty/Researcher), Durmanova, A. (Other Faculty/Researcher), Taurbekova, B. (PhD student/Master degree holder), Sarsenov, R. (Other Faculty/Researcher), Fazli, S. (Other Faculty/Researcher), Ortega, M. A. (Other Faculty/Researcher) & Almawi, W. (Other Faculty/Researcher)

1/1/23 → 12/31/25

Project: Government

Generative Machine Learning for Drug Discovery

Fazli, S. (PI), Molnar, F. (Other Faculty/Researcher), Zazybin, A. (Other Faculty/Researcher), Peshkov, V. (Other Faculty/Researcher), Zollanvari, A. (Other Faculty/Researcher) & Müller, K.-R. (Other Faculty/Researcher)

1/1/23 → 12/31/25

Project: FDCRGP

Defining a redox-dependent pre-apoptotic nuclear condensation in KRAS mutant cancer cells

Sarbassov, D. (PI)

1/1/23 → 12/31/25

Project: FDCRGP

Development of a national clinical and genetic registry for the spectrum of Amyotrophic Lateral Sclerosis (ALS) / Frontotemporal Dementia (FTD) in the Republic of Kazakhstan

Riethmacher, D. (PI), Tokay, T. (Co-PI), Kondybayeva, A. (Co-PI) & Kuanova, L. (Other Faculty/Researcher)

1/1/23 → 12/31/25

Project: CRP

Interference with immune evasion of SARS-CoV-2 and their prospective variants by using protease inhibitors

Burster, T. (PI)

1/1/23 → 12/31/25

Project: FDCRGP

Infectious triggers of chronic autoimmunity in spondyloarthropathy (CITAS)

Kunz Halder, J. (PI), Kushugulova, A. (Co-PI), Ainabekova, B. (Co-PI), Adilbayeva, A. (Postdoctoral scholar (PhD degree holder)), Zhubanchaliyev, A. (Other Faculty/Researcher), Sharip, A. (Other Faculty/Researcher), Nurgaziyeva, A. (Other Faculty/Researcher), Meiramova, A. (Other Faculty/Researcher), Isilbayeva, A. (Other Faculty/Researcher), Beeton, C. (Other Faculty/Researcher), Forslund, S. (Other Faculty/Researcher) & Poddighe, D. (Other Faculty/Researcher)

1/1/21 → 12/31/25

Project: CRP

Targeting KRAS mutant colorectal cancer by inducing a cytotoxic oxidative stress

Sarbassov, D. (PI), Akilzhanova, A. (Co-PI), Bersimbaev, R. (Co-PI), Yermekbayeva, B. (Other Faculty/Researcher), Utepbergenov, D. (Other Faculty/Researcher), Makishev, A. (Other Faculty/Researcher) & Kaidarova, D. (Other Faculty/Researcher)

1/1/21 → 12/31/25

Project: CRP

Human xenosensor CAR as novel target for treatment of metabolic disorders.

Molnar, F. (PI), Fazli, S. (Other Faculty/Researcher), Pogosyan, G. (Co-PI) & Suleimen, Y. (Co-PI)

1/1/20 → 12/31/25

Project: CRP

Finished

Dissecting the cellular effects of SARS-CoV-2 components

Filchakova, O. (PI)

1/1/22 → 12/31/24

Project: FDCRGP

AP14872028: Using Optical and Molecular-biological methods to analyze Harmful Algal Blooms in Kazakhstani Freshwater Lakes and rivers

Barteneva, N. (PI)

1/1/22 → 12/31/24

Project: Government

Multi scale powder mixed EDM induced Functional Surfaces on Biomedical alloys for enhanced mechanical, electrochemical corrosion, tribological and biological performances

Perveen, A. (PI), Talamona, D. (Co-PI), Jahan, M. P. (Co-PI), Nuta, O. (Other Faculty/Researcher), Molardi, C. (Other Faculty/Researcher) & Rahman, M. (Other Faculty/Researcher)

1/1/22 → 12/31/24

Project: FDCRGP

Improving the efficacy of PARP inhibition with Sulfur-Carbon Nanodots through DNA damage response

Xie, Y. (PI) & Dukenbayev, K. (Other Faculty/Researcher)

1/1/22 → 12/31/24

Project: FDCRGP

Oral insulin DNA nanoparticles as immunomodulation therapeutic strategy for diabetes

Hortelano, G. (PI)

1/1/22 → 12/31/24

Project: FDCRGP

Rapid Detection of SARS-CoV-2 Spike Glycoprotein Using An Electrochemical Impedance Sensor

Kanayeva, D. (PI) & Matkarimov, B. (Co-PI)

1/1/21 → 12/31/22

Project: FDCRGP

The early detection of coagulation disbalances in COVID-19 infection using microfluidics chip for extracellular vesicles

Barteneva, N. (PI) & Tikhonov, A. (Other Faculty/Researcher)

1/1/21 → 12/31/22

Project: FDCRGP

Battling host proteases to prevent productive infection by SARS-CoV-2 and severe complications of COVID-19

Burster, T. (PI)

1/1/21 → 12/31/22

Project: FDCRGP

Suppression of SARS-CoV-2 viral replication and assembly by lithium chloride aerosol: Rationale for treatment of COVID-19 patients

Sarbassov, D. (PI) & Yermekbayeva, B. (Co-PI)

1/1/21 → 12/31/23

Project: FDCRGP

IS-MEOR: In-situ microbial enhanced oil recovery

Pham, T. (PI), Hazlett, R. (Co-PI), Yernazarova, A. (Co-PI), Mun, G. (Co-PI), Venturi, V. (Co-PI), Uteyev, R. (Other participant), Zhiengaliev , B. (Other participant), Kitching, M. (Other participant), Mukhtar Shakenuly, M. (Other participant), Ispanbetov, T. (Other participant), Izmailova, A. (Other participant) & Abbas Babikir, A. H. (Other Faculty/Researcher)

1/1/21 → 12/31/24

Project: CRP

Long non-coding RNA and microRNA identification in esophageal squamous cell carcinoma

Rakhimova, S. (PI), Sarbassov, D. (Co-PI) & Makishev, A. (Co-PI)

1/1/21 → 6/30/24

Project: CRP

Building Capacity for Teaching and Research in STEM Teacher Education in Kazakhstan: A Research-Practice Partnership

Goodman, B. (PI), Malone, K. (Co-PI), Nuta, O. (Co-PI) & Makhmetov, A. (Co-PI)

1/1/21 → 12/31/24

Project: CRP

Understanding the Role of CTHRC1 in Synovial Invasiveness in Rheumatoid Arthritis

Kunz, J. (PI), Adilbayeva, A. (Postdoctoral scholar (PhD degree holder)), Manarbek, L. (Other Faculty/Researcher) & Beeton, C. (Other Faculty/Researcher)

1/1/21 → 9/17/24

Project: FDCRGP

Characterization of the biophysical and biomechanical properties of normal and cancer neural stem cells

Pham, T. (PI) & Kriajevskaia, M. (Co-PI)

1/1/21 → 12/31/23

Project: FDCRGP

Epithelial mesenchymal transition mobilizes transposable genetic elements, drives genetic diversity and regulates expression of inflammatory genes in cancer cells

Tulchinsky, E. (PI), Singh, P. (Co-PI) & Schoenbach, C. (Co-PI)

1/2/20 → 12/31/22

Project: FDCRGP

Enhance the tolerance of crop plants to abiotic stresses by modulating the senescence associated gene expression

Soltabayeva, A. (PI)

1/1/20 → 12/31/22

Project: FDCRGP

Identification of the molecular mechanisms preventing YAP-TEAD-mediated cell cycle re-entry in supporting cells of the mouse utricle

Andreeva, A. (PI) & Utepbergenov, D. (Co-PI)

1/1/20 → 11/19/24

Project: FDCRGP

Molecular mechanisms of signaling by human protein DJ-1

Andreeva, A. (PI), Matkarimov, B. (Co-PI), Khassenov, B. (Co-PI) & Utepbergenov, D. (Other Faculty/Researcher)

1/1/20 → 11/19/24

Project: CRP

CD-KAZ: Pediatric Celiac Disease in Kazakhstan: epidemiological analysis and implementation of screening and diagnostic strategies.

Poddighe, D. (PI), Tanko, M. N. (Other Faculty/Researcher), Sazonov, V. (Other Faculty/Researcher), Kozhakhmetova (SSH), A. (Other Faculty/Researcher), Marchenko, Y. (Other Faculty/Researcher), Abdrakhmanova, S. (Other Faculty/Researcher), Catassi, C. (Other Faculty/Researcher), Tinelli, C. (Other Faculty/Researcher), Teleutayev, Y. (Other participant), Ibrayeva, A. (Other participant), Assylbekova, M. (Other participant), Mukusheva, Z. (Other participant) & Kenzhegulova, R. (Other participant)

1/1/20 → 12/31/22

Project: FDCRGP

PAR-DNA: Study of New Covalent DNA Modifications and Their Roles in DNA Repair and Chromatin Organization

Matkarimov, B. (PI), Kanayeva, D. (Co-PI), Begimbetova, D. (Other Faculty/Researcher), Baiken, Y. (Other Faculty/Researcher), Bissenbaev, A. K. (Co-PI), Khassenov, B. (Co-PI), Saparbaev, M. K. (Co-PI), Zharkov, D. O. (Other Faculty/Researcher), Finkelstein, A. V. (Other Faculty/Researcher), Galzitskaya, O. V. (Co-PI), Akishev, Z. (Other Faculty/Researcher), Mussakhmetov, A. (Other Faculty/Researcher), Ishchenko, A. A. (Other Faculty/Researcher) & Taipakova, S. (Other Faculty/Researcher)

1/1/20 → 12/31/22

Project: CRP

АР08053347: Characterization and application of ssDNA aptamers for detection of carcinoembryonic antigen

Kanayeva, D. (PI), Yunussova, N. (Other Faculty/Researcher), Zhumabekova, Z. (Other Faculty/Researcher), Sypabekova, M. (Other Faculty/Researcher), Baiken, Y. (Other Faculty/Researcher), Soltabayeva, A. (Other Faculty/Researcher) & Shola David , M. (Master student/Bachelor degree holder)

1/1/20 → 12/31/22

Project: Government

Development of a diagnostic test for the detection of human antibodies to SARS-CoV-2 (COVID-19)

Hap Hortelano, G. (PI), Schoenbach, C. (Other Faculty/Researcher), Ramankulov, E. (Co-PI), Burster, T. (Co-PI) & Poddighe, D. (Co-PI)

1/1/20 → 12/31/22

Project: FDCRGP

Targeting small GTPase Cdc42 in aged adipose mesenchymal stem cells for the improvement of effectiveness of cell therapy for bone regeneration

Umbayev, B. (PI), Hortelano, G. (Co-PI) & Abilmazhinov, M. (Co-PI)

1/1/20 → 12/31/22

Project: CRP

Characterization of mammalian pre-ribosomal complexes and their deregulation in cancer.

Sarbassov, D. (PI) & Akilzhanova, A. (Co-PI)

1/1/20 → 12/31/23

Project: FDCRGP

Studying activity of peripheral blood monocytes and adiponectin receptors expression in association with plasma adiponectin in patients with Alzheimer’s disease

Askarova, S. (PI) & Barteneva, N. (Co-PI)

1/1/20 → 12/31/22

Project: CRP

EATTST: Enhance anti-tumor therapy efficiency by sequential checkpoint-specific treatment

Vorobyev, I. (PI)

1/1/20 → 12/31/22

Project: FDCRGP

Prostate cancer drug target: Targeting cancer stem-like cells of castration-resistant prostate cancer through combinatorial inhibition of MET/nuclear MET and β-Catenin pathways: potential therapeutic intellectual property in prostate cancer treatment

Xie, Y. (PI), Fan, H. (Co-PI), Dukenbayev, K. (Co-PI) & Chen, Z. (Other Faculty/Researcher)

1/31/19 → 8/31/22

Project: FDCRGP

Phosphatase-like nanozyme activity of carbon nanodots and its potential as supplement for kinase inhibitor drug treating prostate cancer: potential intellectual property discovered in food product

Fan, H. (PI), Xie, Y. (Co-PI) & Chen, Z. (Co-PI)

1/31/19 → 5/31/22

Project: FDCRGP

The phytoplankton communities in space and time: an integrative approach to study salt lakes of Kazakhstanian arid and semiarid zones

Barteneva, N. (PI), Malashenkov, D. (Other Faculty/Researcher), Dashkova, V. (Other participant) & Abilkas, A. (Other participant)

1/31/19 → 12/31/21

Project: FDCRGP

Poison or remedy? The role of bile acids in colorectal cancer

Molnar, F. (PI)

1/31/19 → 12/31/22

Project: FDCRGP

The study of Central Asian Y chromosome variation through ancient DNA from the Chalcolithic to the Early Iron Age and modern populations

Ramankulov, E. (PI), Balanovska, E. (Other participant), Götherström, A. (Other participant), Balanovsky, O. (Other participant), Kashuba, N. (Other participant), Zhabagin, M. (Other Faculty/Researcher), Askapuli, A. (Other Faculty/Researcher) & Issabayeva, K. (Undergraduate student)

1/31/19 → 9/30/22

Project: FDCRGP

Towards understanding α9-nicotinic acetylcholine receptor –mediated mechanisms

Filchakova, O. (PI)

1/31/19 → 12/31/21

Project: FDCRGP

Study of biomarkers associated with oral cavity diseases among the adolescents from different regions of Kazakhstan

Zhumadilova, A. (PI)

4/6/18 → 12/31/20

Project: Government

Microencapsulated cells as a platform for sustained delivery of therapeutic antibodies

Ramankulov, E. (PI) & Burster, T. (PI)

6/1/17 → 7/31/21

Project: ORAU

Department of Biology

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