Laboratory of bioengineering and regenerative medicine

2024

Assessment of hypercholesterolemia prevalence and its demographic variations in the Republic of Kazakhstan

Kulimbet, M., Davletov, K., Saliev, T., Davletov, D., Dzhumabekov, B., Umbayev, B., Balabayeva, A., Tanabayeva, S. & Fakhradiyev, I., Dec 2024, In: Scientific Reports. 14, 1, 7182.

Research output: Contribution to journal › Article › peer-review

Open Access

Biocompatibility and Corrosion of Microplasma-Sprayed Titanium and Tantalum Coatings versus Titanium Alloy

Alontseva, D., Safarova, Y., Voinarovych, S., Obrosov, A., Yamanoglu, R., Khoshnaw, F., Yavuz, H. I., Nessipbekova, A., Syzdykova, A., Azamatov, B., Khozhanov, A. & Weiß, S., Feb 2024, In: Coatings. 14, 2, 206.

Research output: Contribution to journal › Article › peer-review

Open Access

5 Citations (Scopus)

Heart failure in Europe: Guideline-directed medical therapy use and decision making in chronic and acute, pre-existing and de novo, heart failure with reduced, mildly reduced, and preserved ejection fraction – the ESC EORP Heart Failure III Registry

for the ESC EORP HF III National Leaders and Investigators, 2024, (Accepted/In press) In: European Journal of Heart Failure.

Research output: Contribution to journal › Article › peer-review

In vitro and in vivo toxicity of thiolated and PEGylated organosilica nanoparticles

Zhaisanbayeva, B. A., Mun, E. A., Ulmanova, L., Zhunissova, Z., Umbayev, B., Olzhayev, F., Vorobjev, I. A., Hortelano, G. & Khutoryanskiy, V. V., Mar 5 2024, In: International Journal of Pharmaceutics. 652, 123852.

Research output: Contribution to journal › Article › peer-review

Open Access

In vitro cytotoxicity and antiviral activity of aminocaproic acid against SARS-CoV-2

Saliev, T., Tanabayeva, S., Ussebayeva, N., Izmailova, S., Umbayev, B., Akhanov, G., Akhmad, N. & Fakhradiyev, I., 2024, In: Journal of Advanced Pharmacy Education and Research. 14, 3, p. 1-8 8 p.

Research output: Contribution to journal › Article › peer-review

Oral Microbiome Stamp in Alzheimer’s Disease

Issilbayeva, A., Kaiyrlykyzy, A., Vinogradova, E., Jarmukhanov, Z., Kozhakhmetov, S., Kassenova, A., Nurgaziyev, M., Mukhanbetzhanov, N., Alzhanova, D., Zholdasbekova, G., Askarova, S. & Kushugulova, A. R., Mar 2024, In: Pathogens. 13, 3, 195.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Citations (Scopus)

Repair of Rat Calvarial Critical-Sized Defects Using Heparin-Conjugated Fibrin Hydrogel Containing BMP-2 and Adipose-Derived Pericytes

Kudaibergen, G., Mukhlis, S., Mukhambetova, A., Issabekova, A., Sekenova, A., Sarsenova, M., Temirzhan, A., Baidarbekov, M., Umbayev, B. & Ogay, V., May 2024, In: Bioengineering. 11, 5, 437.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Citation (Scopus)

2023

A Brief Review of Current Trends in the Additive Manufacturing of Orthopedic Implants with Thermal Plasma-Sprayed Coatings to Improve the Implant Surface Biocompatibility

Alontseva, D., Azamatov, B., Safarova, Y., Voinarovych, S. & Nazenova, G., Jul 2023, In: Coatings. 13, 7, 1175.

Research output: Contribution to journal › Review article › peer-review

Open Access

8 Citations (Scopus)

Small molecule targeting of the p38/Mk2 stress signaling pathways to improve cancer treatment

Alimbetov, D., Umbayev, B., Tsoy, A., Begimbetova, D., Davis, T., Kipling, D. & Askarova, S., Dec 2023, In: BMC Cancer. 23, 1, 895.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Citations (Scopus)

The Role of Cdc42 in the Insulin and Leptin Pathways Contributing to the Development of Age-Related Obesity

Umbayev, B., Saliev, T., Safarova, Y., Yermekova, A., Olzhayev, F., Bulanin, D., Tsoy, A. & Askarova, S., Dec 2023, In: Nutrients. 15, 23, 4964.

Research output: Contribution to journal › Review article › peer-review

Open Access

1 Citation (Scopus)

2022

Neuroprotective and anti-epileptic potentials of genus Artemisia L

Sailike, B., Omarova, Z., Jenis, J., Adilbayev, A., Akbay, B., Askarova, S., Jin, W-L. & Tokay, T., 2022, In: Frontiers in Pharmacology. 13, p. 1021501

Research output: Contribution to journal › Review article › peer-review

Neuroprotective and anti-epileptic potentials of genus Artemisia L.

Sailike, B., Omarova, Z., Jenis, J., Adilbayev, A., Akbay, B., Askarova, S., Jin, W. L. & Tokay, T., Oct 19 2022, In: Frontiers in Pharmacology. 13, 1021501.

Research output: Contribution to journal › Review article › peer-review

Open Access

5 Citations (Scopus)

Study of gut microbiota alterations in Alzheimer's dementia patients from Kazakhstan

Kaiyrlykyzy, A., Kozhakhmetov, S., Babenko, D., Zholdasbekova, G., Alzhanova, D., Olzhayev, F., Baibulatova, A., Kushugulova, A. R. & Askarova, S., Dec 2022, In: Scientific Reports. 12, 1, 15115.

Research output: Contribution to journal › Article › peer-review

Open Access

44 Citations (Scopus)

The expression levels of pro-inflammatory and anti-inflammatory cytokines and chemokines in blood serum of Alzheimer’s dementia patients: report from a pilot study in Kazakhstan

Askarova, S., Dec 12 2022. 1 p.

Research output: Contribution to conference › Abstract › peer-review

Open Access

2021

Apolipoprotein E polymorphism in Kazakhstani population with Alzheimer’s disease

Askarova, S., Kaiyrlykyzy, A., Olzhayev, F. & Ts, A., Dec 31 2021. 1 p.

Research output: Contribution to conference › Abstract › peer-review

Open Access

Identification of components in Kazakhstan honeys that correlate with antimicrobial activity against wound and skin infecting microorganisms

McLoone, P., Zhumbayeva, A., Yunussova, S., Kaliyev, Y., Yevstafeva, L., Verrall, S., Sungurtas, J., Austin, C., Allwood, J. W. & McDougall, G. J., Dec 2021, In: BMC Complementary Medicine and Therapies. 21, 1, 300.

Research output: Contribution to journal › Article › peer-review

Open Access

7 Citations (Scopus)

Plant extract of limonium gmelinii attenuates oxidative responses in neurons, astrocytes, and cerebral endothelial cells in vitro and improves motor functions of rats after middle cerebral artery occlusion

Nurkenov, T., Tsoy, A., Olzhayev, F., Abzhanova, E., Turgambayeva, A., Zhussupova, A., Avula, B., Ross, S., Aituarova, A., Kassymova, D., Zhusupova, G., Shalakhmetova, T., Tokay, T., Lee, J. C. M. & Askarova, S., Nov 2021, In: Antioxidants. 10, 11, 1814.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Citations (Scopus)

2020

A new insight on the radioprotective potential of epsilon-aminocaproic acid

Saliev, T., Baiskhanova, D., Beznosko, D., Begimbetova, D., Umbayev, B., Nurgozhin, T., Fakhradiyev, I., Tanabayev, B. & Pavalkis, D., 2020, In: Medicina (Lithuania). 56, 12, p. 1-19 19 p., 663.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Citations (Scopus)

Mesenchymal stem cells coated with synthetic bone-targeting polymers enhance osteoporotic bone fracture regeneration

Safarova, Y., Olzhayev, F., Umbayev, B., Tsoy, A., Hortelano, G., Tokay, T., Murata, H., Russell, A. & Askarova, S., Dec 2020, In: Bioengineering. 7, 4, p. 1-16 16 p., 125.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Citation (Scopus)

Mesenchymal stem cells coated with synthetic bone-targeting polymers enhance osteoporotic bone fracture regeneration

Safarova, Y., Olzhayev, F., Umbayev, B., Hortelano, G., Murata, H., Russell, A. & Askarova, S., 2020, (Submitted) In: Cell Transplantation.

Research output: Contribution to journal › Article › peer-review

Polyphenols as caloric-restriction mimetics and autophagy inducers in aging research

Yessenkyzy, A., Saliev, T., Zhanaliyeva, M., Masoud, A. R., Umbayev, B., Sergazy, S., Krivykh, E., Gulyayev, A. & Nurgozhin, T., May 2020, In: Nutrients. 12, 5, 1344.

Research output: Contribution to journal › Review article › peer-review

Open Access

65 Citations (Scopus)

RISK FACTORS FOR AGE-RELATED DEMENTIA IN KAZAKHSTAN: A CASE-CONTROL STUDY

Askarova, S., Kaiyrlykyzy, A., Olzhayev, F., Zhussupova, A. & Alzhanova, D., Jul 7 2020, In: Science & Healthcare . 22, 4, p. 80-85 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Serum adiponectin and methylation of adiponectin gene promoter in peripheral blood of the patients with Alzheimer’s disease and vascular dementia

Askarova, S., Kaiyrlykyzy, A., Ts, A., Olzhayev, F. & Umbayev, B., Dec 7 2020, p. 1-1. 1 p.

Research output: Contribution to conference › Abstract › peer-review

Open Access

2019

Air pollution in kazakhstan and its health risk assessment

Kenessary, D., Kenessary, A., Adilgireiuly, Z., Akzholova, N., Erzhanova, A., Dosmukhametov, A., Syzdykov, D., Masoud, A. R. & Saliev, T., 2019, In: Annals of Global Health. 85, 1, 133.

Research output: Contribution to journal › Article › peer-review

Open Access

31 Citations (Scopus)

Azelnidipine Attenuates the Oxidative and NFκB Pathways in Amyloid-β-Stimulated Cerebral Endothelial Cells

Teng, T., Ridgley, D. M., Tsoy, A., Sun, G. Y., Askarova, S. & Lee, J. C., Jan 16 2019, In: ACS Chemical Neuroscience. 10, 1, p. 209-215 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

10 Citations (Scopus)

Biological effects of non-ionizing electromagnetic fields: Two sides of a coin

Saliev, T., Begimbetova, D., Masoud, A. R. & Matkarimov, B., Jan 2019, In: Progress in Biophysics and Molecular Biology. 141, p. 25-36 12 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

105 Citations (Scopus)

EXPERIMENTAL MODEL OF FOCAL ISCHEMIC BRAIN DAMAGE BY OCCLUSION OF THE MIDDLE CEREBRAL ARTERY: СОЗДАНИЕ ЭКСПЕРИМЕНТАЛЬНОЙ МОДЕЛИ ФОКАЛЬНОГО ИШЕМИЧЕСКОГО ИНСУЛЬТА ГОЛОВНОГО МОЗГА ПУТЕМ ОККЛЮЗИИ СРЕДНЕЙ МОЗГОВОЙ АРТЕРИИ

Olzhayev, F., Feb 13 2019, Patent No. 1748, Feb 13 2019

Research output: Patent

METHOD FOR INFLAMMATION INDUCED CANCER DETECTION IN MOUSE MODEL USING DIFFUSION FLUORESCENT TOMOGRAPHY

Translated title of the contribution: МЕТОД ДЕТЕКЦИИ РАКА, АССОЦИИРОВАННОГО С ВОСПАЛЕНИЕМ НА МЫШИНОЙ МОДЕЛИ С ИСПОЛЬЗОВАНИЕМ ДИФФУЗИННОЙ ФЛУОРЕСЦЕНТНОЙ ТОМОГРАФИИ.Olzhayev, F., Feb 15 2019, Patent No. 1776, Feb 11 2019

Research output: Patent

File

40 Downloads (Pure)

METHOD OF REGULATING SECRETARY PHENOTYPE RELATED TO AGING (Anti-SASP THERAPY) OF SKIN USING SMALL MOLECULES TO ACTIVATE THE REGENERATIVE POTENTIAL OF SKIN IN AGING

Translated title of the contribution: МЕТОДИКА РЕГУЛЯЦИИ СЕКРЕТОРНОГО ФЕНОТИПА, СВЯЗАННОГО СО СТАРЕНИЕМ (Анти-SASP ТЕРАПИИ) КОЖИ С ПОМОЩЬЮ МАЛЫХ МОЛЕКУЛ ДЛЯ АКТИВАЦИИ РЕГЕНЕРАТОРНОГО ПОТЕНЦИАЛА КОЖИ ПРИ СТАРЕНИИ Olzhayev, F., Oct 25 2019, Patent No. 6088, Oct 25 2019

Research output: Patent

The Effects of Mobile Phone Radiofrequency Electromagnetic Fields on β-Amyloid-Induced Oxidative Stress in Human and Rat Primary Astrocytes

Ts, A., Saliev, T., Abzhanova, E., Turgambayeva, A., Kaiyrlykyzy, A., Akishev, M., Saparbayev, S., Umbayev, B. & Askarova, S., Jun 1 2019, In: Neuroscience. 408, p. 46-57 12 p.

Research output: Contribution to journal › Article › peer-review

27 Citations (Scopus)

WOUND COATING BASED ON POLOXAMER 407 AND AMNIOTHIC MEMBRANE EXTRACT

Translated title of the contribution: РАНЕВОЕ ПОКРЫТИЕ НА ОСНОВЕ ПОЛОКСАМЕРА 407 и ЭКСТРАКТА АМНИОТИЧЕСКОЙ МЕМБРАНЫOlzhayev, F., Apr 5 2019, Patent No. 33564

Research output: Patent

КОЛОРЕКТАЛЬДЫҚ ОБЫРДЫҢ СКРИНИНГІ КЕЗІНДЕГІ КОЛОНОСКОПИЯ САПАСЫНЫҢ МЕНЕДЖМЕНТІ

Translated title of the contribution: QUALITY MANAGEMENT OF COLONOSCOPY IN COLORECTAL CANCER SCREENINGOlzhayev, F. & Kanat Batyrbekov, Mar 1 2019, Patent No. 2078, Mar 1 2019

Research output: Patent

Перспективные подходы лечения низкоэнергических травматических повреждений костной ткани с использованием методов биоинженерии и клеточной терапии

Translated title of the contribution: Perspective approaches for treatment of low-energy injury bone tissue injuries using bioengineering methods and cell therapyOlzhayev, F., 2019, In: Science & Healthcare . 21, 5, p. 68-80

Research output: Contribution to journal › Article

Open Access

2018

Brillouin spectroscopy and radiography for assessment of viscoelastic and regenerative properties of mammalian bones

Akilbekova, D., Ogay, V., Yakupov, T., Sarsenova, M., Umbayev, B., Nurakhmetov, A., Tazhin, K., Yakovlev, V. V. & Utegulov, Z. N., Sept 27 2018, In: Journal of Biomedical Optics. 23, 9, p. 1-11 11 p., 097004.

Research output: Contribution to journal › Article › peer-review

30 Citations (Scopus)

Elevated levels of the small GTPase Cdc42 induces senescence in male rat mesenchymal stem cells

Umbayev, B., Masoud, A. R., Ts, A., Alimbetov, D., Olzhayev, F., Shramko, A., Kaiyrlykyzy, A., Safarova, Y., Davis, T. & Askarova, S., Jul 1 2018, In: Biogerontology. 19, 3-4, p. 287-301 15 p.

Research output: Contribution to journal › Article › peer-review

21 Citations (Scopus)

Pharmacological targeting of cell cycle, apoptotic and cell adhesion signaling pathways implicated in chemoresistance of cancer cells

Alimbetov, D., Askarova, S., Umbayev, B., Davis, T. & Kipling, D., Jun 6 2018, In: International journal of molecular sciences. 19, 6, 1690.

Research output: Contribution to journal › Review article › peer-review

Open Access

105 Citations (Scopus)

Role of the small GTPase Cdc42 in rat mesenchymal stem cell aging

Alimbetov, D., 2018, (Submitted) In: Biogerontology.

Research output: Contribution to journal › Article › peer-review

Spatial structure and antimicrobial activity of cyclopropane derivative of limonene

Sadyrbekov, D., Saliev, T., Gatilov, Y., Kulakov, I., Seidakhmetova, R., Seilkhanov, T. & Askarova, S., Apr 2018, In: Natural Product Communications. 13, 4, p. 387-388 2 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Исследование влияния остеофильного бисфосфонатного полимера на пролиферацию, остеогенную дифференцировку адипозных мезенхимальных стволовых клеток и изучение его способности ингибировать активность остеокластов in vitro

Translated title of the contribution: Cell therapy approach for correction of osteoporosis-associated fractures using adipose-derived mesenchymal stem cells functionalized with osteophilic polymerOlzhayev, F., 2018, In: Experimental Biology. 77 , 4 (2018), p. 58-72

Research output: Contribution to journal › Article

Open Access

Метод детекции рака, ассоциированного с воспалением, на мышиной модели с использованием диффузионной флуоресцентной томографии

Translated title of the contribution: Method for inflammation associated cancer detection in mouse model using diffusion fluorescent tomographyAlimbetov, D., Askarova, S., Umbayev, B., Tsoy, A. & Masoud, A-R., 2018, (In preparation)

Research output: Patent

2016

Activated Platelet-Rich Plasma: Cytokine characterization and profiling

Olzhayev, F., Oct 17 2016, p. 473-474 .

Research output: Contribution to conference › Abstract › peer-review

Mesenchymal stem cells coated with synthetic bone-targeted polymer as a new approach for managing of osteoporotic bone fracture regeneration

Olzhayev, F., Oct 19 2016, p. 227-230.

Research output: Contribution to conference › Abstract › peer-review

Open Access

Ovarian reserve and adipokine levels in reproductive-aged obese women

Durmanova, A. K., Otarbayev, N. K., Kaiyrlykyzy, A., Zhangazieva, K. K., Ibrayeva, Z. N., Donenbayeva, G. B., Zhusupova, Z. T., Saidakhmetov, A. S., Temirgaliyeva, G. S., Salykbayeva, Z. K., Tazhigulova, Z. M., Yensebayeva, A. M., Seksembayeva, K. K., Vasilenko, O. K., Timanova, S. & Akkozhina, B., 2016, In: Terapevticheskii Arkhiv. 88, 10, p. 46-50 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

9 Citations (Scopus)

QUALITY MANAGEMENT OF COLONOSCOPY IN COLORECTAL CANCER SCREENING: МЕНЕДЖМЕНТ КАЧЕСТВА КОЛОНОСКОПИИ ПРИ СКРИНИНГЕ КОЛОРЕКТАЛЬНОГО РАКА

Translated title of the contribution: QUALITY MANAGEMENT OF COLONOSCOPY IN COLORECTAL CANCER SCREENINGOlzhayev, F., 2016, Astana: RESEARCH INSTITUTE OF CARDIOLOGY AND INTERNAL MEDICINE. 42 p.

Research output: Book/Report › Scholarly edition

Red blood cell ghosts as promising drug carriers to target wound infections

Berikkhanova, K., Omarbaev, R., Gulyayev, A., Shulgau, Z., Ibrasheva, D., Adilgozhina, G., Sergazy, S., Zhumadilov, Z. & Askarova, S., Sept 1 2016, In: Medical Engineering and Physics. 38, 9, p. 877-884 8 p.

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

2015

DEVICE FOR IN VITRO GAS EXCHANGE FOR TREATMENT OF SEVERE RESPIRATORY FAILURE IN CHILDREN: УСТРОЙСТВО ЭКСТРАКОРПОРАЛЬНОГО ГАЗООБМЕНА ДЛЯ ЛЕЧЕНИЯ ТЯЖЕЛОЙ ДЫХАТЕЛЬНОЙ НЕДОСТАТОЧНОСТИ У ДЕТЕЙ

Olzhayev, F., Jul 15 2015, Patent No. 1287, Jul 15 2015

Research output: Patent

File

54 Downloads (Pure)

2014

EVALUATION OF EXTRACORPOREAL GAS EXCHANGE DEVICE HEMOLUNG FOR POTENTIAL APPLICATION IN PEDIATRIC PRACTICE: Оценка возможности применения системы экстракорпорального газообмена (HEMOLUNG) в педиатрии.

Translated title of the contribution: EVALUATION OF EXTRACORPOREAL GAS EXCHANGE DEVICE HEMOLUNG FOR POTENTIAL APPLICATION IN PEDIATRIC PRACTICEOlzhayev, F., 2014, In: Vestnik Transplantologii i Iskusstvennykh Organov. 16, 4, p. 125-134 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Pre-clinical evaluation of an adult extracorporeal carbon dioxide removal system with active mixing for pediatric respiratory support

Jeffries, R. G., Mussin, Y., Bulanin, D. S., Lund, L. W., Kocyildirim, E., Zhumadilov, Z. Z., Olzhayev, F. S., Federspiel, W. J. & Wearden, P. D., 2014, In: International Journal of Artificial Organs. 37, 12, p. 888-899 12 p.

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Role of ros in aβ42 mediated cell surface p-selectin expression and actin polymerization

Tsoy, A., Shalakhmetova, T., Umbayev, B. & Askarova, S., Sept 1 2014, In: Neurology Asia. 19, 3, p. 309-316 8 p.

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

2013

Amyloid-β Peptide on Sialyl-Lewis^X-Selectin-Mediated Membrane Tether Mechanics at the Cerebral Endothelial Cell Surface

Askarova, S., Sun, Z., Sun, G. Y., Meininger, G. A. & Lee, J. C. M., Apr 12 2013, In: PLoS ONE. 8, 4, e60972.

Research output: Contribution to journal › Article › peer-review

Open Access

12 Citations (Scopus)

Laboratory of bioengineering and regenerative medicine

Research output

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