School of Medicine

  • Kazakhstan

Research Output 1983 2019

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2005
14 Citations (Scopus)

Reduction in coagulation factor VII plasma levels by R353Q but not the- 323P0/10 promoter polymorphism in healthy Tunisians

Mtiraoui, N., Aboud, N., Bouraoui, H., Haizem, S., Gris, J. C., Busson, M., Tamim, H., Almawi, W. Y. & Mahjoub, T., 2005, In : American Journal of Hematology. 79, 1, p. 11-16 6 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Susceptible and protective human leukocyte antigen class II alleles and haplotypes in Bahraini type 2 (non-insulin-dependent) diabetes mellitus patients

Motala, A. A., Busson, M., Al-Harbi, E. M., Khuzam, M. AA., Al-Omari, E. MD., Arekat, M. R. & Almawi, W. Y., 2005, In : Clin. Diagn. Lab. Immunol.. 12, 1, p. 213-217 5 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Takayasu arteritis with high titre of antiphospholipid antibodies and MTHFR polymorphism

Al Jishi, A., Krishnan, P. R. & Almawi, W. Y., 2005, In : Journal of Thrombosis and Thrombolysis. 20, 1, p. 47-50 4 p.

Research output: Contribution to journalArticle

36 Citations (Scopus)

Varied prevalence of factor V G1691A (Leiden) and prothrombin G20210A single nucleotide polymorphisms among Arabs

Almawi, W. Y., Keleshian, S. H., Borgi, L., Fawaz, N. A., Abboud, N., Mtiraoui, N. & Mahjoub, T., 2005, In : Journal of Thrombosis and Thrombolysis. 20, 3, p. 163-168 6 p.

Research output: Contribution to journalArticle

2004
8 Citations (Scopus)

C677T and A1298C single nucleotide polymorphisms in the methylenetetrahydrofolate reductase gene among Bahraini Arabs

Al-Habboubi, H. H., Tamim, H., Ameen, G. & Almawi, W. Y., 2004, In : Thrombosis and Haemostasis. 91, 04, p. 843-845 3 p.

Research output: Contribution to journalArticle

43 Citations (Scopus)

Components of a pathway maintaining histone modification and heterochromatin protein 1 binding at the pericentric heterochromatin in Mammalian cells

Xin, H., Yoon, H-G., Singh, P. B., Wong, J. & Qin, J., Mar 5 2004, In : Journal of Biological Chemistry. 279, 10, p. 9539-46 8 p.

Research output: Contribution to journalArticle

Histone Code
Heterochromatin
Protein Binding
Histones
Cells
32 Citations (Scopus)

Differences in the frequency of the C677T mutation in the methylenetetrahydrofolate reductase (MTHFR) gene among the Lebanese population

Almawi, W. Y., Finan, R. R., Tamim, H., Daccache, J. L. & Irani-Hakime, N., 2004, In : American Journal of Hematology. 76, 1, p. 85-87 3 p.

Research output: Contribution to journalArticle

210 Citations (Scopus)

Dimethylation of histone H3 lysine 9 is a critical mark for DNA methylation and gene silencing in Arabidopsis thaliana

Jackson, J. P., Johnson, L., Jasencakova, Z., Zhang, X., PerezBurgos, L., Singh, P. B., Cheng, X., Schubert, I., Jenuwein, T. & Jacobsen, S. E., Mar 2004, In : Chromosoma. 112, 6, p. 308-15 8 p.

Research output: Contribution to journalArticle

Gene Silencing
DNA Methylation
Arabidopsis
Histones
Lysine
54 Citations (Scopus)

Dynamic relocation of epigenetic chromatin markers reveals an active role of constitutive heterochromatin in the transition from proliferation to quiescence

Grigoryev, S. A., Nikitina, T., Pehrson, J. R., Singh, P. B. & Woodcock, C. L., Dec 1 2004, In : Journal of Cell Science. 117, Pt 25, p. 6153-62 10 p.

Research output: Contribution to journalArticle

Heterochromatin
Epigenomics
Chromatin
Lymphocytes
Histone Code
45 Citations (Scopus)

Factor V G1691A, prothrombin G20210A, and methylenetetrahydrofolate reductase [MTHFR] C677T gene polymorphism in angiographically documented coronary artery disease

Almawi, W. Y., Ameen, G., Tamim, H., Finan, R. R. & Irani-Hakime, N., 2004, In : Journal of Thrombosis and Thrombolysis. 17, 3, p. 199-205 7 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Factor V-Leiden, prothrombin G20210A, and MTHFR C677T mutations among patients with sickle cell disease in Eastern Saudi Arabia

Fawaz, N. A., Bashawery, L., Al-Sheikh, I., Qatari, A., Al-Othman, S. S. & Almawi, W. Y., 2004, In : American Journal of Hematology. 76, 3, p. 307-309 3 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Factor V Leiden, prothrombin G20210A and antibodies against phospholipids in recurrent spontaneous abortion

Mtiraoui, N., Borgi, L., Gris, J-C., Almawi, WY. & Mahjoub, T., 2004, In : Journal of Thrombosis and Haemostasis. 2, 8, p. 1482-1484 3 p.

Research output: Contribution to journalArticle

38 Citations (Scopus)

Hepatitis B and hepatitis C virus prevalence among dialysis patients in Bahrain and Saudi Arabia: a survey by serologic and molecular methods

Qadi, A. A., Tamim, H., Ameen, G., Bu-Ali, A., Al-Arrayed, S., Fawaz, N. A. & Almawi, W. Y., 2004, In : American Journal of Infection Control. 32, 8, p. 493-495 3 p.

Research output: Contribution to journalArticle

182 Citations (Scopus)

Heterochromatin and tri-methylated lysine 20 of histone H4 in animals

Kourmouli, N., Jeppesen, P., Mahadevhaiah, S., Burgoyne, P., Wu, R., Gilbert, D. M., Bongiorni, S., Prantera, G., Fanti, L., Pimpinelli, S., Shi, W., Fundele, R. & Singh, P. B., May 15 2004, In : Journal of Cell Science. 117, Pt 12, p. 2491-501 11 p.

Research output: Contribution to journalArticle

Heterochromatin
Histones
Lysine
Chromosomes
Polytene Chromosomes
18 Citations (Scopus)

Highly efficient mRNA-based gene transfer in feeder-free cultured H9 human embryonic stem cells

Ponsaerts, P., van der Sar, S., Van Tendeloo, V. F. I., Jorens, P. G., Berneman, Z. N. & Singh, P. B., 2004, In : Cellular Reprogramming. 6, 3, p. 211-6 6 p.

Research output: Contribution to journalArticle

Messenger RNA
Electroporation
Genes
Transgenes
Viruses

HLA class II profile and distribution of HLA-DRB1 and HLA-DQB1 alleles and haplotypes among Lebanese and Bahraini Arabs

Almawi, W. Y., Busson, M., Tamim, H., Al-Harbi, E. M., Finan, R. R., Wakim-Ghorayeb, S. F. & Motala, A. A., 2004, In : Clin. Diagn. Lab. Immunol.. 11, 4, p. 770-774 5 p.

Research output: Contribution to journalArticle

IMMUNE-MEDIATED RESPONSES AND DISORDERS-Specific HLA-DRB and-DQB Alleles and Haplotypes Confer Disease Susceptibility or Resistance in Bahraini Type 1 Diabetes Patients

Al-Harbi, E. M., Abbassi, A-J., Tamim, H., al-Jenaidi, F., Kooheji, M., Kamal, M., al-Mahroos, S., al-Nasir, F., Motala, A. A. & Almawi, W. Y., 2004, In : Clinical and Diagnostic Laboratory Immunology. 11, 2, p. 292-296 5 p.

Research output: Contribution to journalArticle

57 Citations (Scopus)

In vivo dynamics of Swi6 in yeast: evidence for a stochastic model of heterochromatin

Cheutin, T., Gorski, S. A., May, K. M., Singh, P. B. & Misteli, T., Apr 2004, In : Molecular and Cellular Biology. 24, 8, p. 3157-67 11 p.

Research output: Contribution to journalArticle

Heterochromatin
Yeasts
Schizosaccharomyces
Chromatin
Mammals
3 Citations (Scopus)

Is seroprevalence of HTLV-I/II among blood donors in Lebanon relevant?

Tamim, H., Musharrafieh, U., Ramia, S., Almawi, W. Y., Al-Jisr, T., Ayoub, T., Nabulsi-Majzoub, M., Kazma, H. & Baz, E. K., 2004, In : American Journal of Infection Control. 32, 4, p. 220-223 4 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Messenger RNA electroporation is highly efficient in mouse embryonic stem cells: successful FLPe- and Cre-mediated recombination

Ponsaerts, P., Brown, J. P., Van den Plas, D., Van den Eeden, L., Van Bockstaele, D. R., Jorens, P. G., Van Tendeloo, V. F. I., Merregaert, J., Singh, P. B. & Berneman, Z. N., Nov 2004, In : Gene Therapy. 11, 21, p. 1606-10 5 p.

Research output: Contribution to journalArticle

Electroporation
Genetic Recombination
Embryonic Stem Cells
Messenger RNA
Transgenes
76 Citations (Scopus)

Mitotic phosphorylation of histone H3 at threonine 3

Polioudaki, H., Markaki, Y., Kourmouli, N., Dialynas, G., Theodoropoulos, P. A., Singh, P. B. & Georgatos, S. D., Feb 27 2004, In : FEBS Letters. 560, 1-3, p. 39-44 6 p.

Research output: Contribution to journalArticle

Phosphorylation
Nuclear Envelope
Threonine
Histones
Chromatin
22 Citations (Scopus)

NF-Y regulates the antisense promoter, bidirectional silencing, and differential epigenetic marks of the Kcnq1 imprinting control region

Pandey, R. R., Ceribelli, M., Singh, P. B., Ericsson, J., Mantovani, R. & Kanduri, C., Dec 10 2004, In : Journal of Biological Chemistry. 279, 50, p. 52685-93 9 p.

Research output: Contribution to journalArticle

Transcription
Epigenomics
Transcription Factors
Methylation
Binding Sites
43 Citations (Scopus)

On the link between Bcl-2 family proteins and glucocorticoid-induced apoptosis

Almawi, W. Y., Melemedjian, O. K. & Jaoude, M. M. A., 2004, In : Journal of Leukocyte Biology. 76, 1, p. 7-14 8 p.

Research output: Contribution to journalArticle

63 Citations (Scopus)

Outbreak of Burkholderia cepacia bacteremia traced to contaminated hospital water used for dilution of an alcohol skin antiseptic

Nasser, R. M., Rahi, A. C., Haddad, M. F., Daoud, Z., Irani-Hakime, N. & Almawi, W. Y., 2004, In : Infection Control and Hospital Epidemiology. 25, 3, p. 231-239 9 p.

Research output: Contribution to journalArticle

44 Citations (Scopus)

Prevalence of seromarkers of HBV and HCV among blood donors in eastern Saudi Arabia, 1998--2001

Bashawri, LAM., Fawaz, NA., Ahmad, MS., Qadi, AA. & Almawi, WY., 2004, In : International Journal of Laboratory Hematology. 26, 3, p. 225-228 4 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Specific HLA-DRB and-DQB alleles and haplotypes confer disease susceptibility or resistance in Bahraini type 1 diabetes patients

Al-Harbi, E. M., Abbassi, A-J., Tamim, H., al-Jenaidi, F., Kooheji, M., Kamal, M., al-Mahroos, S., al-Nasir, F., Motala, A. A. & Almawi, W. Y., 2004, In : Clin. Diagn. Lab. Immunol.. 11, 2, p. 292-296 5 p.

Research output: Contribution to journalArticle

104 Citations (Scopus)

The inner nuclear membrane protein lamin B receptor forms distinct microdomains and links epigenetically marked chromatin to the nuclear envelope

Makatsori, D., Kourmouli, N., Polioudaki, H., Shultz, L. D., McLean, K., Theodoropoulos, P. A., Singh, P. B. & Georgatos, S. D., Jun 11 2004, In : Journal of Biological Chemistry. 279, 24, p. 25567-73 7 p.

Research output: Contribution to journalArticle

Heterochromatin
Nuclear Envelope
Nuclear Proteins
Oligomers
Histones
1 Citation (Scopus)

Thromboembolism and toxic shock syndrome: A case presentation and literature update

Musharrafieh, UM., Jamaleddine, GW., Taher, AT., Almawi, WY. & Tabbara, ZA., 2004, In : Journal of Thrombosis and Thrombolysis. 17, 2, p. 133-137 5 p.

Research output: Contribution to journalArticle

2003
4 Citations (Scopus)

A common mutation in 5, 10-methylenetetrahydrofolate reductase (MTHFR) gene in two Arab communities

Al-Habboubi, H., Tamim, H., Ameen, G. & Almawi, WY., 2003, In : Journal of Thrombosis and Haemostasis. 1, 10, p. 2246-2248 3 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Comparison of daclizumab, an interleukin 2 receptor antibody, to anti-thymocyte globulin-Fresenius induction therapy in kidney transplantation

Abou-Jaoude, M. M., Ghantous, I. & Almawi, W. Y., 2003, In : Molecular Immunology. 39, 17-18, p. 1083-1088 6 p.

Research output: Contribution to journalArticle

32 Citations (Scopus)

Exposure of children to environmental tobacco smoke (ETS) and its association with respiratory ailments

Tamim, H., Musharrafieh, U., Roueiheb, Z. E., Yunis, K. & Almawi, W. Y., 2003, In : Journal of Asthma. 40, 5, p. 571-576 6 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

Insulation of the chicken beta-globin chromosomal domain from a chromatin-condensing protein, MENT

Istomina, N. E., Shushanov, S. S., Springhetti, E. M., Karpov, V. L., Krasheninnikov, I. A., Stevens, K., Zaret, K. S., Singh, P. B. & Grigoryev, S. A., Sep 2003, In : Molecular and Cellular Biology. 23, 18, p. 6455-68 14 p.

Research output: Contribution to journalArticle

beta-Globins
Histones
Chromatin
Chickens
Insulator Elements
9 Citations (Scopus)

Intraoperative anti-thymocyte globulin-Fresenius (ATG-F) administration as induction immunosuppressive therapy in kidney transplantation

Abou-Jaoude, M. M. & Almawi, W. Y., 2003, In : Molecular Immunology. 39, 17-18, p. 1089-1094 6 p.

Research output: Contribution to journalArticle

431 Citations (Scopus)

Maintenance of stable heterochromatin domains by dynamic HP1 binding

Cheutin, T., McNairn, A. J., Jenuwein, T., Gilbert, D. M., Singh, P. B. & Misteli, T., Jan 31 2003, In : Science. 299, 5607, p. 721-5 5 p.

Research output: Contribution to journalArticle

Heterochromatin
Protein Binding
Maintenance
Chromatin
Euchromatin
7 Citations (Scopus)

Prevalence of hepatitis C virus isolate genotypes from chronically infected Lebanese patients

Mokhbat, J., Irani-Hakime, N., Samaha, H., Almawi, W., Abou Jaoude, M., Daccache, J. & Rahal, E., 2003, In : Journal Medical Libanais. 51, 3, p. 121-126 5 p.

Research output: Contribution to journalArticle

Prevalence of hepatitis C virus isolate genotypes from chronically infected Lebanese patients: a hospital-based study.

Irani-Hakime, N., Samaha, H., Almawi, W., Nasr, E., Mokhbat, J., Abou, M. J., Daccache, J. & Rahal, E., 2003, In : Journal Medical Libanais. 51, 3, p. 121-126 6 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Single-center experience with tacrolimus-based immunosuppressive regimens in renal transplantation

Abou-Jaoude, M. M. & Almawi, W. Y., 2003, In : Molecular Immunology. 39, 17-18, p. 1067-1072 6 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)
287 Citations (Scopus)

Trimethylated lysine 9 of histone H3 is a mark for DNA methylation in Neurospora crassa

Tamaru, H., Zhang, X., McMillen, D., Singh, P. B., Nakayama, J., Grewal, S. I., Allis, C. D., Cheng, X. & Selker, E. U., May 2003, In : Nature Genetics. 34, 1, p. 75-9 5 p.

Research output: Contribution to journalArticle

Neurospora crassa
DNA Methylation
Histones
Lysine
Methylation
2002
54 Citations (Scopus)

Cervicovaginal coinfections with human papillomavirus and Chlamydia trachomatis

Tamim, H., Finan, R. R., Sharida, H. E., Rashid, M. & Almawi, W. Y., 2002, In : Diagnostic Microbiology and Infectious Disease. 43, 4, p. 277-281 5 p.

Research output: Contribution to journalArticle

Crystallization and preliminary crystallographic studies on the chromo shadow domain (CSD) of mouse heterochromatin protein M31

Gao, Y., Ding, Y., Singh, P. B. & Rao, Z., Jun 2002, In : Acta Crystallographica Section D: Structural Biology. 58, Pt 6 Pt 2, p. 1051-3 3 p.

Research output: Contribution to journalArticle

Heterochromatin
Crystallization
Non Histone Chromosomal Proteins
Gene Silencing
Epigenomics
218 Citations (Scopus)

Heterochromatin, HP1 and methylation at lysine 9 of histone H3 in animals

Cowell, I. G., Aucott, R., Mahadevaiah, S. K., Burgoyne, P. S., Huskisson, N., Bongiorni, S., Prantera, G., Fanti, L., Pimpinelli, S., Wu, R., Gilbert, D. M., Shi, W., Fundele, R., Morrison, H., Jeppesen, P. & Singh, P. B., Mar 2002, In : Chromosoma. 111, 1, p. 22-36 15 p.

Research output: Contribution to journalArticle

Heterochromatin
Histones
Methylation
Lysine
Chromosomes
39 Citations (Scopus)

Identification of Chlamydia trachomatis DNA in human papillomavirus (HPV) positive women with normal and abnormal cytology

Finan, RR., Tamim, H. & Almawi, WY., 2002, In : Archives of Gynecology and Obstetrics. 266, 3, p. 168-171 4 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)

Loss of heterochromatin protein 1 (HP1) chromodomain function in mammalian cells by intracellular antibodies causes cell death

Filesi, I., Cardinale, A., van der Sar, S., Cowell, I. G., Singh, P. B. & Biocca, S., May 1 2002, In : Journal of Cell Science. 115, Pt 9, p. 1803-13 11 p.

Research output: Contribution to journalArticle

Immunoglobulin Variable Region
Single-Chain Antibodies
Cause of Death
Cell Death
Antibodies

Maternal regulation of imprinting

Kathirvel, P. K. & Singh, P. B., Sep 2002, In : Journal of Biosciences. 27, 5, p. 437-8 2 p.

Research output: Contribution to journalArticle

132 Citations (Scopus)

Molecular mechanisms of glucocorticoid antiproliferative effects: antagonism of transcription factor activity by glucocorticoid receptor

Almawi, W. Y. & Melemedjian, O. K., 2002, In : Journal of Leukocyte Biology. 71, 1, p. 9-15 7 p.

Research output: Contribution to journalArticle

171 Citations (Scopus)

Negative regulation of nuclear factor-kappaB activation and function by glucocorticoids.

Almawi, WY. & Melemedjian, OK., 2002, In : Journal of Molecular Endocrinology. 28, 2, p. 69-78 10 p.

Research output: Contribution to journalArticle

88 Citations (Scopus)

Prevalence of factor V G1691A (factor V-Leiden) and prothrombin G20210A gene mutations in a recurrent miscarriage population

Finan, R. R., Tamim, H., Ameen, G., Sharida, H. E., Rashid, M. & Almawi, W. Y., 2002, In : American Journal of Hematology. 71, 4, p. 300-305 6 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Prevalence of two thrombophilia predisposing mutations: factor V G1691A (R506Q; Leiden) and prothrombin G20210A, among healthy Lebanese

Tamim, H., Finan, R. R. & Almawi, W. Y., 2002, In : Thrombosis and Haemostasis. 88, 10, p. 691-692 2 p.

Research output: Contribution to journalArticle

81 Citations (Scopus)

The Ki-67 protein interacts with members of the heterochromatin protein 1 (HP1) family: a potential role in the regulation of higher-order chromatin structure

Scholzen, T., Endl, E., Wohlenberg, C., van der Sar, S., Cowell, I. G., Gerdes, J. & Singh, P. B., Feb 2002, In : Journal of Pathology. 196, 2, p. 135-44 10 p.

Research output: Contribution to journalArticle

Chromatin
Proteins
Neoplasms
Nuclear Proteins
HeLa Cells