School of Medicine

  • Kazakhstan

Research Output 1983 2020

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2002
27 Citations (Scopus)

Loss of heterochromatin protein 1 (HP1) chromodomain function in mammalian cells by intracellular antibodies causes cell death

Filesi, I., Cardinale, A., van der Sar, S., Cowell, I. G., Singh, P. B. & Biocca, S., May 1 2002, In : Journal of Cell Science. 115, Pt 9, p. 1803-13 11 p.

Research output: Contribution to journalArticle

Immunoglobulin Variable Region
Single-Chain Antibodies
Cause of Death
Cell Death
Antibodies

Maternal regulation of imprinting

Kathirvel, P. K. & Singh, P. B., Sep 2002, In : Journal of Biosciences. 27, 5, p. 437-8 2 p.

Research output: Contribution to journalArticle

132 Citations (Scopus)

Molecular mechanisms of glucocorticoid antiproliferative effects: antagonism of transcription factor activity by glucocorticoid receptor

Almawi, W. Y. & Melemedjian, O. K., 2002, In : Journal of Leukocyte Biology. 71, 1, p. 9-15 7 p.

Research output: Contribution to journalArticle

171 Citations (Scopus)

Negative regulation of nuclear factor-kappaB activation and function by glucocorticoids.

Almawi, WY. & Melemedjian, OK., 2002, In : Journal of Molecular Endocrinology. 28, 2, p. 69-78 10 p.

Research output: Contribution to journalArticle

88 Citations (Scopus)

Prevalence of factor V G1691A (factor V-Leiden) and prothrombin G20210A gene mutations in a recurrent miscarriage population

Finan, R. R., Tamim, H., Ameen, G., Sharida, H. E., Rashid, M. & Almawi, W. Y., 2002, In : American Journal of Hematology. 71, 4, p. 300-305 6 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Prevalence of two thrombophilia predisposing mutations: factor V G1691A (R506Q; Leiden) and prothrombin G20210A, among healthy Lebanese

Tamim, H., Finan, R. R. & Almawi, W. Y., 2002, In : Thrombosis and Haemostasis. 88, 10, p. 691-692 2 p.

Research output: Contribution to journalArticle

81 Citations (Scopus)

The Ki-67 protein interacts with members of the heterochromatin protein 1 (HP1) family: a potential role in the regulation of higher-order chromatin structure

Scholzen, T., Endl, E., Wohlenberg, C., van der Sar, S., Cowell, I. G., Gerdes, J. & Singh, P. B., Feb 2002, In : Journal of Pathology. 196, 2, p. 135-44 10 p.

Research output: Contribution to journalArticle

Chromatin
Proteins
Neoplasms
Nuclear Proteins
HeLa Cells
37 Citations (Scopus)

Transcriptional and post-transcriptional mechanisms of glucocorticoid antiproliferative effects

Almawi, W. Y., Abou Jaoude, M. M. & Li, X. C., 2002, In : Hematological Oncology. 20, 1, p. 17-32 16 p.

Research output: Contribution to journalArticle

2001
20 Citations (Scopus)

Binding of heterochromatin protein 1 to the nuclear envelope is regulated by a soluble form of tubulin

Kourmouli, N., Dialynas, G., Petraki, C., Pyrpasopoulou, A., Singh, P. B., Georgatos, S. D. & Theodoropoulos, P. A., Apr 20 2001, In : Journal of Biological Chemistry. 276, 16, p. 13007-14 8 p.

Research output: Contribution to journalArticle

Nuclear Envelope
Tubulin
Carrier Proteins
Proteins
Purification
5 Citations (Scopus)

Detection of human papillomavirus (HPV) genotypes in cervico-vaginal scrapes of women with normal and abnormal cytology

Finan, RR., Irani-Hakime, N., Tamim, H., Sharide, HE., Daccache, JL. & Almawi, WY., 2001, In : Clinical Microbiology and Infection. 7, 12, p. 688-692 5 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Factor V R506Q mutation-Leiden: an independent risk factor for venous thrombosis but not coronary artery disease

Irani-Hakime, N., Tamim, H., Elias, G., Choueiry, S., Kreidy, R., Daccache, J. L. & Almawi, W. Y., 2001, In : Journal of Thrombosis and Thrombolysis. 11, 2, p. 111-116 6 p.

Research output: Contribution to journalArticle

FJ Express Summaries-Inhibition of cytokine production and interference in IL-2 receptor-mediated Jak-Stat signaling by the hydroxyiamine metabolite of sulfamethoxazole

Hess, DA., O'Leary, EF., Lee, JT., Almawi, WY., Madrenas, J. & Rieder, MJ., 2001, In : FASEB Journal-Federation of American Societies for Experimental Biology. 15, 10, p. 1855-1857 3 p.

Research output: Contribution to journalArticle

High Prevalence of Human Papilloma Virus Genotype 16 in Abnormal pap Smear: a Hospital Based Study

Hakime, N., Finan, RR., Aftimos, GA., Azzam-Gedeon, G. & Almawi, WY., 2001, In : REVUE MEDICALE LIBANAISE. 13, 3, p. 111-111 1 p.

Research output: Contribution to journalArticle

127 Citations (Scopus)

Histones H3/H4 form a tight complex with the inner nuclear membrane protein LBR and heterochromatin protein 1

Polioudaki, H., Kourmouli, N., Drosou, V., Bakou, A., Theodoropoulos, P. A., Singh, P. B., Giannakouros, T. & Georgatos, S. D., Oct 2001, In : EMBO Reports. 2, 10, p. 920-5 6 p.

Research output: Contribution to journalArticle

Nuclear Envelope
Nuclear Proteins
Histones
Membrane Proteins
CREB-Binding Protein

Increased Prevalence of Mixed Chronic Hepatitis C Infection in the Lebanese Population; A Hospital Based Study

Hakime, N., Almawi, W., Karam, WG., Daoud, Z., Samaha, H., Daccache, J., Rassam, P. & Aoun, JP., 2001, In : REVUE MEDICALE LIBANAISE. 13, 3, p. 109-110 2 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Inhibition of cytokine production and cytokine-stimulated T-cell activation by FK506 (tacrolimus) 1

Almawi, W. Y., Assi, J. W., Chudzik, D. M., Jaoude, M. M. A. & Rieder, M. J., 2001, In : Cell Transplantation. 10, 7, p. 615-623 9 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Inhibition of cytokine production and interference in IL-2 receptor-mediated Jak-Stat signaling by the hydroxylamine metabolite of sulfamethoxazole

Hess, D. A., O’LEARY, ERIN. F., Lee, J. T., Almawi, W. Y., Madrenas, J. & Rieder, M. J., 2001, In : FASEB Journal. 15, 10, p. 1855-1857 3 p.

Research output: Contribution to journalArticle

58 Citations (Scopus)

M31 and macroH2A1.2 colocalise at the pseudoautosomal region during mouse meiosis

Turner, J. M., Burgoyne, P. S. & Singh, P. B., Sep 2001, In : Journal of Cell Science. 114, Pt 18, p. 3367-75 9 p.

Research output: Contribution to journalArticle

Meiosis
Heterochromatin
Y Chromosome
X Chromosome
Proteins

Molecular diagnosis of human papillomavirus (HPV): Comparison between cervical and vaginal sampling

FINAN, R. R., IRANI-HAKIME, N., TAMIM, H. & ALMAWI, W. Y., 2001, In : Revue médicale libanaise. 13, 3, p. 92-94 3 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Posttranscriptional Mechanisms of Glucocorticoid Antiproliferative Effects: Glucocorticoids Inhibit IL-6-Induced Proliferation of B9 Hybridoma Cells

Almawi, W. Y. & Tamim, H., 2001, In : Cell Transplantation. 10, 2, p. 161-164 4 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Prevalence of antibodies against hepatitis C virus among blood donors in Lebanon, 1997--2000

Irani-Hakime, N., Tamim, H., Samaha, H. & Almawi, WY., 2001, In : International Journal of Laboratory Hematology. 23, 5, p. 317-323 7 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Seroprevalence of hepatitis C infection among health care personnel in Beirut, Lebanon

Irani-Hakime, N., Aoun, J-P., Khoury, S., Samaha, H. R., Tamim, H. & Almawi, W. Y., 2001, In : American Journal of Infection Control. 29, 1, p. 20-23 4 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Seroprevalence of hepatitis C virus (HCV) infection among blood donors: a hospital-based study

Tamim, H., Irani-Hakime, N., Aoun, J-P., Khoury, S., Samaha, H. & Almawi, W. Y., 2001, In : Transfusion and Apheresis Science. 24, 1, p. 29-35 7 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Smoking among adolescents in a developing country

Tamim, H., Musharrafieh, U. & Almawi, W. Y., 2001, In : Australian and New Zealand Journal of Public Health. 25, 2, p. 185 1 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

The gene and pseudogenes of Cbx3/mHP1 gamma

Jones, D. O., Mattei, M. G., Horsley, D., Cowell, I. G. & Singh, P. B., 2001, In : DNA Sequence - Journal of DNA Sequencing and Mapping. 12, 3, p. 147-60 14 p.

Research output: Contribution to journalArticle

Pseudogenes
Genes
Introns
Chromosomes, Human, Pair 13
Chromosomes, Human, Pair 4
2000
55 Citations (Scopus)

Clinical and mechanistic differences between FK506 (tacrolimus) and cyclosporin A

Almawi, W. Y. & Melemedjian, O. K., 2000, In : Nephrology Dialysis Transplantation. 15, 12, p. 1916-1918 3 p.

Research output: Contribution to journalArticle

95 Citations (Scopus)

Conservation of heterochromatin protein 1 function

Wang, G., Ma, A., Chow, C. M., Horsley, D., Brown, N. R., Cowell, I. G. & Singh, P. B., Sep 2000, In : Molecular and Cellular Biology. 20, 18, p. 6970-83 14 p.

Research output: Contribution to journalArticle

Heterochromatin
Proteins
Yeasts
Genes
Schizosaccharomyces
88 Citations (Scopus)

Dynamic associations of heterochromatin protein 1 with the nuclear envelope

Kourmouli, N., Theodoropoulos, P. A., Dialynas, G., Bakou, A., Politou, A. S., Cowell, I. G., Singh, P. B. & Georgatos, S. D., Dec 1 2000, In : EMBO Journal. 19, 23, p. 6558-68 11 p.

Research output: Contribution to journalArticle

Nuclear Envelope
His-His-His-His-His-His
Proteins
Lamin Type B
Acetylation
11 Citations (Scopus)

Embryonic inheritance of the chromatin organisation of the imprinted H19 domain in mouse spermatozoa

Banerjee, S., Singh, P. B., Rasberry, C. & Cattanach, B. M., Feb 2000, In : Mechanisms of Development. 90, 2, p. 217-26 10 p.

Research output: Contribution to journalArticle

Chromatin
Spermatozoa
Alleles
Embryonic Structures
Methylation
22 Citations (Scopus)

High prevalence of factor V mutation (Leiden) in the Eastern Mediterranean

Irani-Hakime, N., Tamim, H., Elias, G., Finan, R. R., Daccache, J. L. & Almawi, W. Y., 2000, In : Clinical Chemistry. 46, 1, p. 134-136 3 p.

Research output: Contribution to journalArticle

Methylenetetrahydrofolate reductase gene polymorphisms in Egyptian women with unexplained recurrent pregnancy loss.

Attili, R., Hussein, A., Odeh, H., Hejaz, H., Irani-Hakime, N., Tamim, H., Elias, G., Finan, RR., Daccache, JL. & Almawi, WY., 2000, In : Research Journal of Obstetrics and Gynecology. 12, 1, p. 134-136 3 p.

Research output: Contribution to journalArticle

49 Citations (Scopus)

The murine heterochromatin protein M31 is associated with the chromocenter in round spermatids and Is a component of mature spermatozoa

Hoyer-Fender, S., Singh, P. B. & Motzkus, D., Jan 10 2000, In : Experimental Cell Research. 254, 1, p. 72-9 8 p.

Research output: Contribution to journalArticle

Spermatids
Heterochromatin
Spermatozoa
Chromatin
Proteins
59 Citations (Scopus)

The prevalence of factor V R506Q mutation-Leiden among apparently healthy Lebanese

Irani-Hakime, N., Tamim, H., Kreidy, R. & Almawi, W. Y., 2000, In : American Journal of Hematology. 65, 1, p. 45-49 5 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Validity of vaginal testing in detecting human papillomavirus (HPV) genotypes

Finan, R. R., Irani-Hakime, N., Tamim, H. & Almawi, W. Y., 2000, In : Journal of Clinical Virology. 19, 3, p. 163-168 6 p.

Research output: Contribution to journalArticle

1999
74 Citations (Scopus)

An alternate mechanism of glucocorticoid anti-proliferative effect: promotion of a Th2 cytokine-secreting profile

Almawi, WY., Melemedjian, OK. & Rieder, MJ., 1999, In : Clinical Transplantation. 13, 5, p. 365-374 10 p.

Research output: Contribution to journalArticle

367 Citations (Scopus)

Functional mammalian homologues of the Drosophila PEV-modifier Su(var)3-9 encode centromere-associated proteins which complex with the heterochromatin component M31

Aagaard, L., Laible, G., Selenko, P., Schmid, M., Dorn, R., Schotta, G., Kuhfittig, S., Wolf, A., Lebersorger, A., Singh, P. B., Reuter, G. & Jenuwein, T., Apr 1 1999, In : EMBO Journal. 18, 7, p. 1923-38 16 p.

Research output: Contribution to journalArticle

Chromosomal Position Effects
Heterochromatin
Centromere
Drosophila
Chromatin
106 Citations (Scopus)

Heterochromatin protein 1 modifies mammalian PEV in a dose- and chromosomal-context-dependent manner

Festenstein, R., Sharghi-Namini, S., Fox, M., Roderick, K., Tolaini, M., Norton, T., Saveliev, A., Kioussis, D. & Singh, P., Dec 1999, In : Nature Genetics. 23, 4, p. 457-61 5 p.

Research output: Contribution to journalArticle

Chromosomal Position Effects
Transgenes
Locus Control Region
Transgenic Mice
Mammals
279 Citations (Scopus)

KAP-1 corepressor protein interacts and colocalizes with heterochromatic and euchromatic HP1 proteins: a potential role for Krüppel-associated box-zinc finger proteins in heterochromatin-mediated gene silencing

Ryan, R. F., Schultz, D. C., Ayyanathan, K., Singh, P. B., Friedman, J. R., Fredericks, W. J. & Rauscher, F. J., Jun 1999, In : Molecular and Cellular Biology. 19, 6, p. 4366-78 13 p.

Research output: Contribution to journalArticle

Co-Repressor Proteins
Heterochromatin
Zinc Fingers
Gene Silencing
Genes
45 Citations (Scopus)

M31, a murine homolog of Drosophila HP1, is concentrated in the XY body during spermatogenesis

Motzkus, D., Singh, P. B. & Hoyer-Fender, S., 1999, In : Cytogenetic and Genome Research. 86, 1, p. 83-8 6 p.

Research output: Contribution to journalArticle

Sex Chromosomes
Spermatogenesis
Drosophila
Spermatocytes
Heterochromatin
11 Citations (Scopus)

Opposing effects of rapamycin and cyclosporin A on activation-induced Ca2+ release

Almawi, W. Y., Assi, J. W., Chudzik, D. M. & Lazarovits, A. I., 1999, In : European Journal of Pharmacology. 381, 1, p. 51-56 6 p.

Research output: Contribution to journalArticle

39 Citations (Scopus)

Pretreatment with glucocorticoids enhances T-cell effector function: possible implication for immune rebound accompanying glucocorticoid withdrawal

Almawi, W. Y., Hess, D. A., Assi, J. W., Chudzik, D. M. & Rieder, M. J., 1999, In : Cell Transplantation. 8, 6, p. 637-647 11 p.

Research output: Contribution to journalArticle

Pretreatment With Glucocorticoids Enhances T-Cell Effector Function: Possible Implication for Immune Rebound Accompanying Glucocorticoid Withdrawal

Almawi, W. Y., Hess, D. A., Assi, J. W., Chudzik, D. M. & Rieder, M. J., 1999, In : Cell Transplantation. 8, 6, p. 637-648 12 p.

Research output: Contribution to journalArticle

69 Citations (Scopus)

T helper type 1 and 2 cytokines mediate the onset and progression of type I (insulin-dependent) diabetes

Almawi, W. Y., Tamim, H. & Azar, S. T., 1999, In : Journal of Clinical Endocrinology and Metabolism. 84, 5, p. 1497-1502 6 p.

Research output: Contribution to journalArticle

38 Citations (Scopus)

Type I (insulin-dependent) diabetes is a Th1-and Th2-mediated autoimmune disease

Azar, S. T., Tamim, H., Beyhum, H. N., Habbal, M. Z. & Almawi, W. Y., 1999, In : Clin. Diagn. Lab. Immunol.. 6, 3, p. 306-310 5 p.

Research output: Contribution to journalArticle

1998
31 Citations (Scopus)

Multiplicity of glucocorticoid action in inhibiting allograft rejection

Almawi, W. Y., Hess, D. A. & Rieder, M. J., 1998, In : Cell Transplantation. 7, 6, p. 511-523 13 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Significance of enhanced cytokine receptor expression by glucocorticoids

Almawi, W. Y., Hess, D. A. & Rieder, M. J., 1998, In : Blood. 92, 10, p. 3979-3979 1 p.

Research output: Contribution to journalArticle

35 Citations (Scopus)

The fission yeast chromo domain encoding gene chp1(+) is required for chromosome segregation and shows a genetic interaction with alpha-tubulin

Doe, C. L., Wang, G., Chow, C., Fricker, M. D., Singh, P. B. & Mellor, E. J., Sep 15 1998, In : Nucleic Acids Research. 26, 18, p. 4222-9 8 p.

Research output: Contribution to journalArticle

Chromosome Segregation
Schizosaccharomyces
Centromere
Tubulin
Chromatin
10 Citations (Scopus)

The M31 gene has a complex developmentally regulated expression profile and may encode alternative protein products that possess diverse subcellular localisation patterns

Peterson, K., Wang, G., Horsley, D., Richardson, J. C., Sapienza, C., Latham, K. E. & Singh, P. B., Mar 1 1998, In : Journal of Experimental Zoology. 280, 4, p. 288-303 16 p.

Research output: Contribution to journalArticle

protein products
genes
centromeres
heterochromatin
chromosome segregation
1997

Altered Cytokine Production Induced by Sulfamethoxazole Hydroxylamine: PI-1

Hess, D., Almawi, W., Puvanesasingham, R. & Rieder, M., 1997, In : Clinical Pharmacology and Therapeutics. 61, 2

Research output: Contribution to journalArticle