Gonzalo Hortelano, PhD

Professor, Project Manager

Former affiliation
  • 1784 Citations
  • 20 h-Index
1994 …2020

Research output per year

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Research Output

2020

Co-administration of FVIII with IVIG: Effect on Immune Response to FVIII in Hemophilia A Mice.

Afraz, S., Stevic, I., Matino, D., Wen, J., Atkinson, H., Chan, A. & Hortelano, G., 2020, (Submitted) In : Journal of Thrombosis and Haemostasis.

Research output: Contribution to journalArticle

Mesenchymal stem cells modifications for enhanced bone targeting and bone regeneration

Safarova, Y., Umbayev, B., Hortelano, G. & Askarova, S., Apr 1 2020, In : Regenerative Medicine. 15, 4, p. 1579-1594 16 p.

Research output: Contribution to journalArticle

Open Access

Optimization of Chitosan DNA Nanoparticles for Gene Delivery: DNA concentration, ionic strength and N:P ratio are key determinants of transfection efficiency.

Yerkesh, Z., Dhadwar, S. S., Raimbekova, A., Yerishova, A., Tolemyrzayeva, S., Satayeva, M., Negmetzhanov, B., Chan, A. & Hortelano, G., 2020, (Submitted) In : Pharmaceutics.

Research output: Contribution to journalArticle

Psoriasisis associated with elevated gut IL-1 and intestinal microbiome alterations: results of a cross-sectional study from Central Asia.

Yegorov, S., Babenko, D., Kozhakhmetov, S., Akhmaltdinova, L., Nurgozhina, A., Nurgaziyev, M., Good, S., Hortelano, G., Yermekbayeva, B. & Kushugulova, A., 2020, (Submitted) In : Frontiers in Immunology.

Research output: Contribution to journalArticle

Transmission of HIV and HCV within Former Soviet Union Countries.

Zhangwen Ge, Yi, F., Shao, Y., DeHovitz, J., Vermund, S. & Ali, S., 2020, In : Canadian Journal of Gastroenterology and Hepatology. ID 9701920.

Research output: Contribution to journalArticle

2019

Cell Encapsulation Within Alginate Microcapsules: Immunological Challenges and Outlook

Ashimova, A., Yegorov, S., Negmetzhanov, B. & Hortelano, G., Dec 3 2019, In : Frontiers in Bioengineering and Biotechnology. 7, 380.

Research output: Contribution to journalReview article

Open Access
1 Citation (Scopus)

Co-administration of factor VIII with intravenous immunoglobulin reduces immune response to factor VIII in hemophilia A mice.

Afraz, S., Wen, J., Chan, A. & Hortelano, G., 2019, Research and Practice in Thrombosis and Hemostasis .

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Oral nanoparticles with FVIII and IL-10 DN: Effect on the immune response to FVIII in hemophilia mice

Yerkesh, Z., Raimbekova, A., Yerishova, A., Stanova, A., Yerzhan, A., Afraz, S., Chan, A. & Hortelano, G., 2019, Research and Practice in Thrombosis and Hemostasis .

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2018

First demonstration of anti-hepatitis E virus antibodies in Kazakhstan

Cainelli, F., Hortelano, G., Negmetzhanov, B., Ibrayeva, A., Kaliaskarova, K., Bulanin, D. & Vento, S., 2018, In : Cent Asian J Glob Health. 7, 1

Research output: Contribution to journalArticle

Molecular epidemiology of HIV-1 subtype A in former Soviet Union countries

Aibekova, L., Foley, B., Hortelano, G., Raees, M., Abdraimov, S., Toichuev, R. & Ali, S., Feb 2018, In : PLoS ONE. 13, 2, e0191891.

Research output: Contribution to journalArticle

5 Citations (Scopus)
2016

Chitosan DNA nanoparticles for oral gene delivery

Patel, B., Vignesh, N. & Hortelano, G., 2016, In : World J Med Genet . 6, 3, p. 22-33

Research output: Contribution to journalReview article

nMet, a new target in recurrent cancer

Xie, Y., Istayeva, S., Chen, Z., Tokay, T., Zhumadilov, Z., Wu, D., Hortelano, G. & Zhang, J., Sep 1 2016, In : Current Cancer Drug Targets. 16, 7, p. 572-578 7 p.

Research output: Contribution to journalReview article

4 Citations (Scopus)
2015

Fibronectin-Alginate microcapsules improve cell viability and protein secretion of encapsulated Factor IX-engineered human mesenchymal stromal cells

Sayyar, B., Dodd, M., Marquez-Curtis, L., Janowska-Wieczorek, A. & Hortelano, G., Jan 1 2015, In : Artificial Cells, Nanomedicine and Biotechnology. 43, 5, p. 318-327 10 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)
2014

Cell-matrix Interactions of Factor IX (FIX)-engineered human mesenchymal stromal cells encapsulated in RGD-alginate vs. Fibrinogen-alginate microcapsules

Sayyar, B., Dodd, M., Marquez-Curtis, L., Janowska-Wieczorek, A. & Hortelano, G., Apr 2014, In : Artificial Cells, Nanomedicine and Biotechnology. 42, 2, p. 102-109 8 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Sustained expression of coagulation factor IX by modified cord blood-derived mesenchymal stromal cells

Dodd, M., Marquez-Curtis, L., Janowska-Wieczorek, A. & Hortelano, G., Jan 1 2014, In : Journal of Gene Medicine. 16, 5-6, p. 131-142 12 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)
2012

Encapsulated engineered myoblasts can cure Hurler syndrome: Preclinical experiments in the mouse model

Piller Puicher, E., Tomanin, R., Salvalaio, M., Friso, A., Hortelano, G., Marin, O. & Scarpa, M., Apr 1 2012, In : Gene Therapy. 19, 4, p. 355-364 10 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Encapsulation of factor IX-engineered mesenchymal stem cells in fibrinogen-alginate microcapsules enhances their viability and transgene secretion

Sayyar, B., Dodd, M., Wen, J., Ma, S., Marquez-Curtis, L., Janowska-Wieczorek, A. & Hortelano, G., Dec 1 2012, In : Journal of Tissue Engineering. 3, 1, p. 1-12 12 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Ex-vivo gene therapy approach for continuous delivery of BDNF and its potential use for neurological disorders

Gomez-Vargas, A., Hortelano, G. & Rathbone, M., 2012, Neurology. 1 ed. Vol. 78.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Single-colour flow cytometric assay to determine NK cell-mediated cytotoxicity and viability against non-adherent human tumor cells

Thakur, A., Zaman, A., Hummel, J., Jones, K. & Hortelano, G., Mar 1 2012, In : Biotechnology Letters. 34, 3, p. 447-453 7 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Strategies for ocular siRNA delivery: Potential and limitations of non-viral nanocarriers

Thakur, A., Fitzpatrick, S., Zaman, A., Kugathasan, K., Muirhead, B., Hortelano, G. & Sheardown, H., Jun 11 2012, In : Journal of Biological Engineering. 6, 7.

Research output: Contribution to journalArticle

23 Citations (Scopus)

Ultrasound-Assisted Tissue Plasminogen Activator Delivery to Ischemic Strokes

Zamat, A., Thakura, A., Rashedi, I. & Hortelano, G., 2012, In : Journal of Young Investigators. 23, 5

Research output: Contribution to journalArticle

2011

Co-administration therapy modulates immunity to FVIII In Hemophilia A mice.

Hortelano, G., Wen, J. & Chan, A., 2011.

Research output: Contribution to conferencePaper

2010

Advances in Experimental Medicine and Biology: Foreword

Hortelano, G., Dec 1 2010, Therapeutic Applications of Cell Microencapsulation. Pedraz, J. & Orive, G. (eds.). p. vii-viii (Advances in Experimental Medicine and Biology; vol. 670).

Research output: Chapter in Book/Report/Conference proceedingForeword/postscript

3 Citations (Scopus)

Characterization of viability and proliferation of alginate-poly-L-lysine- alginate encapsulated myoblasts using flow cytometry

Thakur, A., Sengupta, R., Matsui, H., Lillicrap, D., Jones, K. & Hortelano, G., Aug 2010, In : Journal of Biomedical Materials Research - Part B Applied Biomaterials. 94, 2, p. 296-304 9 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Monkey business for hemophilia management

Hortelano, G., Nov 1 2010, In : Thrombosis Research. 126, 5, p. 365-366 2 p.

Research output: Contribution to journalEditorial

Repeated oral administration of chitosan/DNA nanoparticles delivers functional FVIII with the absence of antibodies in hemophilia A mice

Dhadwar, S. S., Kiernan, J., Wen, J. & Hortelano, G., Dec 1 2010, In : Journal of Thrombosis and Haemostasis. 8, 12, p. 2743-2750 8 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)
2009

Early intraplatelet signaling enhances the release of human platelet PAR-1 and -4 amino-terminal peptides in response to thrombin

Ofosu, F. A., Dewar, L., Song, Y., Cedrone, A. C., Hortelano, G. & Craven, S. J., Feb 24 2009, In : Biochemistry. 48, 7, p. 1562-1572 11 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)
2008

Factors that contribute to the immmunogenicity of therapeutic recombinant human proteins

Mukovozov, I., Sabljic, T., Hortelano, G. & Ofosu, F. A., May 1 2008, In : Thrombosis and Haemostasis. 99, 5, p. 874-882 9 p.

Research output: Contribution to journalReview article

34 Citations (Scopus)
2007

Encapsulated human primary myoblasts deliver functional hFIX in hemophilic mice

Wen, J., Xu, N., Li, A., Bourgeois, J., Ofosu, F. A. & Hortelano, G., Nov 1 2007, In : Journal of Gene Medicine. 9, 11, p. 1002-1010 9 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Transplants for Hemophilia

Gómez-Vargas, A. & Hortelano, G., Dec 1 2007, Cellular Transplantation. Elsevier, p. 187-203 17 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2006

Sustained and therapeutic levels of human factor IX in hemophilia B mice implanted with microcapsules: Key role of encapsulated cells

Wen, J., Vargas, A. G., Ofosu, F. A. & Hortelano, G., Mar 1 2006, In : Journal of Gene Medicine. 8, 3, p. 362-369 8 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)
2005

An important role for the activation peptide domain in controlling factor IX levels in the blood of haemophilia B mice

Begbie, M. E., Mamdani, A., Gataiance, S., Eltringham-Smith, L. J., Bhakta, V., Hortelano, G. & Sheffield, W. P., Dec 1 2005, In : Thrombosis and Haemostasis. 94, 6, p. 1138-1147 10 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Gene therapy using encapsulated cells.

Hortelano, G., 2005, Applications of Cell Immobilisation Biotechnology: Focus on Biotechnology. Kluwer Academic Publishers, Vol. 8B:229-247.

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Reduction of GAG storage in MPS II mouse model following implantation on encapsulated recombinant myoblasts

Friso, A., Tomanin, R., Alba, S., Gasparotto, N., Puicher, E. P., Fusco, M., Hortelano, G., Muenzer, J., Marin, O., Zacchello, F. & Scarpa, M., Nov 1 2005, In : Journal of Gene Medicine. 7, 11, p. 1482-1491 10 p.

Research output: Contribution to journalArticle

34 Citations (Scopus)
2004

Continuous antigenic stimulation system (CASS) as a new immunization strategy

Gomez-Vargas, A., Rosenthal, K. L., McDermott, M. R. & Hortelano, G., Sep 28 2004, In : Vaccine. 22, 29-30, p. 3902-3910 9 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Effects of genetic fusion of factor IX to albumin on in vivo clearance in mice and rabbits

Sheffield, W. P., Mamdani, A., Hortelano, G., Gataiance, S., Eltringham-Smith, L., Begbie, M. E., Leyva, R. A., Liaw, P. S. & Ofosu, F. A., Aug 2004, In : British Journal of Haematology. 126, 4, p. 565-573 9 p.

Research output: Contribution to journalArticle

32 Citations (Scopus)

History, challenges and perspectives of cell microencapsulation

Orive, G., Hernández, R. M., Rodríguez Gascón, A., Calafiore, R., Chang, T. M. S., De Vos, P., Hortelano, G., Hunkeler, D., Lacík, I. & Pedraz, J. L., Feb 2004, In : Trends in Biotechnology. 22, 2, p. 87-92 6 p.

Research output: Contribution to journalReview article

287 Citations (Scopus)

Nonviral gene therapy approaches to hemophilia

Gómez-Vargas, A. & Hortelano, G., Apr 1 2004, In : Seminars in Thrombosis and Hemostasis. 30, 2, p. 197-204 8 p.

Research output: Contribution to journalReview article

9 Citations (Scopus)
2003

Cell encapsulation: Promise and progress

Orive, G., Hernández, R. M., Gascón, A. R., Calafiore, R., Chang, T. M. S., De Vos, P., Hortelano, G., Hunkeler, D., Lacík, I., Shapiro, A. M. J. & Pedraz, J. L., Jan 1 2003, In : Nature Medicine. 9, 1, p. 104-107 4 p.

Research output: Contribution to journalReview article

464 Citations (Scopus)

Somatic gene therapy of mucopolysaccharidosis type II by encapsulated recombinant myoblasts

Friso, A., Tomanin, R., Alba, S., Pillar Puicher, E., Gasparotto, N., Fusco, M., Hortelano, G., Muenzer, J., Zachello, F. & Scarpa, M., 2003, Molecular Therapy. 5 ed. Vol. 7.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2002

Non-viral transfer approaches for the gene therapy of mucopolysaccharidosis type II (Hunter syndrome)

Tomanin, R., Friso, A., Alba, S., Piller Puicher, E., Mennuni, C., La Monica, N., Hortelano, G., Zacchello, F. & Scarpa, M., Dec 1 2002, In : Acta Paediatrica, International Journal of Paediatrics, Supplement. 91, 439, p. 100-104 5 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Polymer-encapsulated engineered adult mesenchymal stem cells secrete exogenously regulated rhBMP-2, and induce osteogenic and angiogenic tissue formation

Zilberman, Y., Turgeman, G., Pelled, G., Xu, N., Moutsatsos, I. K., Hortelano, G. & Gazit, D., Jan 1 2002, In : Polymers for Advanced Technologies. 13, 10-12, p. 863-870 8 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Therapeutic levels of human Factor VIII in mice implanted with encapsulated cells: Potential for gene therapy of haemophilia A

García-Martín, C., Chuah, M. K. L., Van Damme, A., Robinson, K. E., Vanzieleghem, B., Saint-Remy, J. M., Gallardo, D., Ofosu, F. A., Vandendriessche, T. & Hortelano, G., Mar 1 2002, In : Journal of Gene Medicine. 4, 2, p. 215-223 9 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)
2001

Sustained and therapeutic delivery of factor IX in nude haemophilia B mice by encapsulated C2C12 myoblasts: Concurrent tumourigenesis

Hortelano, G., Wang, L., Xu, N. & Ofosu, F. A., Apr 10 2001, In : Haemophilia. 7, 2, p. 207-214 8 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)
2000

Gene therapy for hemophilia

Hortelano, G. & Chang, P. L., Jan 1 2000, In : Artificial Cells, Blood Substitutes, and Immobilization Biotechnology. 28, 1, p. 1-24 24 p.

Research output: Contribution to journalReview article

13 Citations (Scopus)

Induction of angiogenesis by implantation of encapsulated primary myoblasts expressing vascular endothelial growth factor

Springer, M. L., Hortelano, G., Bouley, D. M., Wong, J., Kraft, P. E. & Blau, H. M., 2000, In : Journal of Gene Medicine. 2, 4, p. 279-288 10 p.

Research output: Contribution to journalArticle

49 Citations (Scopus)

Therapeutic approaches for haemophilia

Hortelano, G. & Ofosu, F. A., Jan 1 2000, In : Expert Opinion on Therapeutic Patents. 10, 6, p. 929-938 10 p.

Research output: Contribution to journalReview article

1999

Persistent delivery of factor IX in mice: Gene therapy for hemophilia using implantable microcapsules

Hortelano, G., Xu, N., Vandenberg, A., Solera, J., Chang, P. L. & Ofosu, F. A., May 20 1999, In : Human Gene Therapy. 10, 8, p. 1281-1288 8 p.

Research output: Contribution to journalArticle

38 Citations (Scopus)