Gonzalo Hortelano, PhD

Professor, Project Manager

  • 1752 Citations
  • 20 h-Index
1994 …2022
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Research Output 1994 2018

  • 1752 Citations
  • 20 h-Index
  • 39 Article
  • 1 Chapter
  • 1 Review article
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Article
2018
3 Citations (Scopus)

Molecular epidemiology of HIV-1 subtype A in former Soviet Union countries

Aibekova, L., Foley, B., Hortelano Hap, G., Raees, M., Abdraimov, S., Toichuev, R. & Ali, S., Feb 1 2018, In : PLoS One. 13, 2, e0191891.

Research output: Contribution to journalArticle

molecular epidemiology
Molecular Epidemiology
USSR
Human immunodeficiency virus 1
HIV-1
2015
3 Citations (Scopus)

Fibronectin-Alginate microcapsules improve cell viability and protein secretion of encapsulated Factor IX-engineered human mesenchymal stromal cells

Sayyar, B., Dodd, M., Marquez-Curtis, L., Janowska-Wieczorek, A. & Hortelano, G., 2015, In : Artificial Cells, Nanomedicine and Biotechnology. 43, 5, p. 318-327 10 p.

Research output: Contribution to journalArticle

Factor IX
Alginate
Mesenchymal Stromal Cells
Fibronectins
Capsules
2014
11 Citations (Scopus)

Cell-matrix Interactions of Factor IX (FIX)-engineered human mesenchymal stromal cells encapsulated in RGD-alginate vs. Fibrinogen-alginate microcapsules

Sayyar, B., Dodd, M., Marquez-Curtis, L., Janowska-Wieczorek, A. & Hortelano, G., 2014, In : Artificial Cells, Nanomedicine and Biotechnology. 42, 2, p. 102-109 8 p.

Research output: Contribution to journalArticle

Factor IX
Alginate
Mesenchymal Stromal Cells
Cell Communication
Fibrinogen
6 Citations (Scopus)

Sustained expression of coagulation factor IX by modified cord blood-derived mesenchymal stromal cells

Dodd, M., Marquez-Curtis, L., Janowska-Wieczorek, A. & Hortelano, G., 2014, In : Journal of Gene Medicine. 16, 5-6, p. 131-142 12 p.

Research output: Contribution to journalArticle

Factor IX
Mesenchymal Stromal Cells
Fetal Blood
Hemophilia B
Coagulants
2012
11 Citations (Scopus)

Encapsulated engineered myoblasts can cure Hurler syndrome: Preclinical experiments in the mouse model

Piller Puicher, E., Tomanin, R., Salvalaio, M., Friso, A., Hortelano, G., Marin, O. & Scarpa, M., Apr 2012, In : Gene Therapy. 19, 4, p. 355-364 10 p.

Research output: Contribution to journalArticle

Mucopolysaccharidosis I
Myoblasts
Iduronidase
Glycosaminoglycans
Capsules
20 Citations (Scopus)

Encapsulation of factor IX-engineered mesenchymal stem cells in fibrinogen-alginate microcapsules enhances their viability and transgene secretion

Sayyar, B., Dodd, M., Wen, J., Ma, S., Marquez-Curtis, L., Janowska-Wieczorek, A. & Hortelano, G., 2012, In : Journal of Tissue Engineering. 3, 1, p. 1-12 12 p.

Research output: Contribution to journalArticle

Factor IX
Alginate
Stem cells
Mesenchymal Stromal Cells
Transgenes
3 Citations (Scopus)

Single-colour flow cytometric assay to determine NK cell-mediated cytotoxicity and viability against non-adherent human tumor cells

Thakur, A., Zaman, A., Hummel, J., Jones, K. & Hortelano, G., Mar 2012, In : Biotechnology Letters. 34, 3, p. 447-453 7 p.

Research output: Contribution to journalArticle

Cytotoxicity
Natural Killer Cells
Tumors
Assays
Flow cytometry
21 Citations (Scopus)

Strategies for ocular siRNA delivery: Potential and limitations of non-viral nanocarriers

Thakur, A., Fitzpatrick, S., Zaman, A., Kugathasan, K., Muirhead, B., Hortelano, G. & Sheardown, H., Jun 11 2012, In : Journal of Biological Engineering. 6, 7.

Research output: Contribution to journalArticle

RNA
Small Interfering RNA
Gene expression
Pharmaceutical Preparations
Intraocular Injections
2010
3 Citations (Scopus)
Medicine
Biomedical Research
13 Citations (Scopus)

Characterization of viability and proliferation of alginate-poly-L-lysine- alginate encapsulated myoblasts using flow cytometry

Thakur, A., Sengupta, R., Matsui, H., Lillicrap, D., Jones, K. & Hortelano, G., 2010, In : Journal of Biomedical Materials Research - Part B Applied Biomaterials. 94, 2, p. 296-304 9 p.

Research output: Contribution to journalArticle

Flow cytometry
Myoblasts
Alginate
Flow Cytometry
Lysine

Monkey business for hemophilia management

Hortelano, G., Nov 2010, In : Thrombosis Research. 126, 5, p. 365-366 2 p.

Research output: Contribution to journalArticle

Animal Disease Models
Macaca fascicularis
Hemophilia A
Genetic Therapy
19 Citations (Scopus)

Repeated oral administration of chitosan/DNA nanoparticles delivers functional FVIII with the absence of antibodies in hemophilia A mice

Dhadwar, S. S., Kiernan, J., Wen, J. & Hortelano, G., Dec 2010, In : Journal of Thrombosis and Haemostasis. 8, 12, p. 2743-2750 8 p.

Research output: Contribution to journalArticle

Chitosan
Hemophilia A
Nanoparticles
Oral Administration
Antibodies
Drug Compounding
Cell Transplantation
Polymers
Therapeutics
2009
3 Citations (Scopus)

Early intraplatelet signaling enhances the release of human platelet PAR-1 and -4 amino-terminal peptides in response to thrombin

Ofosu, F. A., Dewar, L., Song, Y., Cedrone, A. C., Hortelano, G. & Craven, S. J., Feb 24 2009, In : Biochemistry. 48, 7, p. 1562-1572 11 p.

Research output: Contribution to journalArticle

Platelets
Thrombin
Blood Platelets
Peptides
Peptide Hydrolases
2008
34 Citations (Scopus)

Factors that contribute to the immmunogenicity of therapeutic recombinant human proteins

Mukovozov, I., Sabljic, T., Hortelano, G. & Ofosu, F. A., May 2008, In : Thrombosis and Haemostasis. 99, 5, p. 874-882 9 p.

Research output: Contribution to journalArticle

Recombinant Proteins
Proteins
Amino Acid Sequence
Therapeutics
Protein Deficiency
2007
15 Citations (Scopus)

Encapsulated human primary myoblasts deliver functional hFIX in hemophilic mice

Wen, J., Xu, N., Li, A., Bourgeois, J., Ofosu, F. A. & Hortelano, G., Nov 2007, In : Journal of Gene Medicine. 9, 11, p. 1002-1010 9 p.

Research output: Contribution to journalArticle

Factor IX
Myoblasts
Hemophilia B
Capsules
SCID Mice
2006
25 Citations (Scopus)

Sustained and therapeutic levels of human factor IX in hemophilia B mice implanted with microcapsules: Key role of encapsulated cells

Wen, J., Vargas, A. G., Ofosu, F. A. & Hortelano, G., Mar 2006, In : Journal of Gene Medicine. 8, 3, p. 362-369 8 p.

Research output: Contribution to journalArticle

Hemophilia B
Factor IX
Capsules
Myoblasts
Therapeutics
2005
21 Citations (Scopus)

An important role for the activation peptide domain in controlling factor IX levels in the blood of haemophilia B mice

Begbie, M. E., Mamdani, A., Gataiance, S., Eltringham-Smith, L. J., Bhakta, V., Hortelano, G. & Sheffield, W. P., Dec 2005, In : Thrombosis and Haemostasis. 94, 6, p. 1138-1147 10 p.

Research output: Contribution to journalArticle

Hemophilia B
Factor IX
Protein Domains
Proteins
Peptides
33 Citations (Scopus)

Reduction of GAG storage in MPS II mouse model following implantation on encapsulated recombinant myoblasts

Friso, A., Tomanin, R., Alba, S., Gasparotto, N., Puicher, E. P., Fusco, M., Hortelano, G., Muenzer, J., Marin, O., Zacchello, F. & Scarpa, M., Nov 2005, In : Journal of Gene Medicine. 7, 11, p. 1482-1491 10 p.

Research output: Contribution to journalArticle

Mucopolysaccharidosis II
Myoblasts
Glycosaminoglycans
Iduronate Sulfatase
Mucopolysaccharidosis I
2004
7 Citations (Scopus)

Continuous antigenic stimulation system (CASS) as a new immunization strategy

Gomez-Vargas, A., Rosenthal, K. L., McDermott, M. R. & Hortelano, G., Sep 28 2004, In : Vaccine. 22, 29-30, p. 3902-3910 9 p.

Research output: Contribution to journalArticle

Immunization
immunization
Factor IX
mice
immune response
32 Citations (Scopus)

Effects of genetic fusion of factor IX to albumin on in vivo clearance in mice and rabbits

Sheffield, W. P., Mamdani, A., Hortelano, G., Gataiance, S., Eltringham-Smith, L., Begbie, M. E., Leyva, R. A., Liaw, P. S. & Ofosu, F. A., Aug 2004, In : British Journal of Haematology. 126, 4, p. 565-573 9 p.

Research output: Contribution to journalArticle

Factor IX
Albumins
Rabbits
Proteins
Half-Life
282 Citations (Scopus)

History, challenges and perspectives of cell microencapsulation

Orive, G., Hernández, R. M., Rodríguez Gascón, A., Calafiore, R., Chang, T. M. S., De Vos, P., Hortelano, G., Hunkeler, D., Lacík, I. & Pedraz, J. L., Feb 2004, In : Trends in Biotechnology. 22, 2, p. 87-92 6 p.

Research output: Contribution to journalArticle

Microencapsulation
Drug Compounding
Biotechnology
Encapsulation
Medicine
9 Citations (Scopus)

Nonviral gene therapy approaches to hemophilia

Gómez-Vargas, A. & Hortelano, G., Apr 2004, In : Seminars in Thrombosis and Hemostasis. 30, 2, p. 197-204 8 p.

Research output: Contribution to journalArticle

Hemophilia A
Genetic Therapy
Factor IX
Factor VIII
Transgenes
2003
452 Citations (Scopus)

Cell encapsulation: Promise and progress

Orive, G., Hernández, R. M., Gascón, A. R., Calafiore, R., Chang, T. M. S., De Vos, P., Hortelano, G., Hunkeler, D., Lacík, I., Shapiro, A. M. J. & Pedraz, J. L., Jan 1 2003, In : Nature Medicine. 9, 1, p. 104-107 4 p.

Research output: Contribution to journalArticle

Encapsulation
Technology
Artificial Membranes
Heterologous Transplantation
Animals
2002
21 Citations (Scopus)

Non-viral transfer approaches for the gene therapy of mucopolysaccharidosis type II (Hunter syndrome)

Tomanin, R., Friso, A., Alba, S., Piller Puicher, E., Mennuni, C., La Monica, N., Hortelano, G., Zacchello, F. & Scarpa, M., 2002, In : Acta Paediatrica, International Journal of Paediatrics, Supplement. 91, 439, p. 100-104 5 p.

Research output: Contribution to journalArticle

Mucopolysaccharidosis II
Iduronate Sulfatase
Genetic Therapy
Fibroblasts
Genes
17 Citations (Scopus)

Polymer-encapsulated engineered adult mesenchymal stem cells secrete exogenously regulated rhBMP-2, and induce osteogenic and angiogenic tissue formation

Zilberman, Y., Turgeman, G., Pelled, G., Xu, N., Moutsatsos, I. K., Hortelano, G. & Gazit, D., Oct 2002, In : Polymers for Advanced Technologies. 13, 10-12, p. 863-870 8 p.

Research output: Contribution to journalArticle

Stem cells
Capsules
Polymers
Bone
Tissue
31 Citations (Scopus)

Therapeutic levels of human Factor VIII in mice implanted with encapsulated cells: Potential for gene therapy of haemophilia A

García-Martín, C., Chuah, M. K. L., Van Damme, A., Robinson, K. E., Vanzieleghem, B., Saint-Remy, J. M., Gallardo, D., Ofosu, F. A., Vandendriessche, T. & Hortelano, G., Mar 2002, In : Journal of Gene Medicine. 4, 2, p. 215-223 9 p.

Research output: Contribution to journalArticle

Hemophilia A
Genetic Therapy
Capsules
Madin Darby Canine Kidney Cells
SCID Mice
2001
29 Citations (Scopus)

Sustained and therapeutic delivery of factor IX in nude haemophilia B mice by encapsulated C2C12 myoblasts: Concurrent tumourigenesis

Hortelano, G., Wang, L., Xu, N. & Ofosu, F. A., 2001, In : Haemophilia. 7, 2, p. 207-214 8 p.

Research output: Contribution to journalArticle

Hemophilia B
Factor IX
Myoblasts
Partial Thromboplastin Time
Capsules
2000
13 Citations (Scopus)

Gene therapy for hemophilia

Hortelano, G. & Chang, P. L., Jan 2000, In : Artificial Cells, Blood Substitutes, and Immobilization Biotechnology. 28, 1, p. 1-24 24 p.

Research output: Contribution to journalArticle

Gene therapy
Hemophilia A
Genetic Therapy
Factor IX
Factor VIII
49 Citations (Scopus)

Induction of angiogenesis by implantation of encapsulated primary myoblasts expressing vascular endothelial growth factor

Springer, M. L., Hortelano, G., Bouley, D. M., Wong, J., Kraft, P. E. & Blau, H. M., 2000, In : Journal of Gene Medicine. 2, 4, p. 279-288 10 p.

Research output: Contribution to journalArticle

Myoblasts
Vascular Endothelial Growth Factor A
Capsules
Smooth Muscle Myocytes
Macrophages

Therapeutic approaches for haemophilia

Hortelano, G. & Ofosu, F. A., 2000, In : Expert Opinion on Therapeutic Patents. 10, 6, p. 929-938 10 p.

Research output: Contribution to journalArticle

Factor VIII
Hemophilia A
contagious disease
gene therapy
Factor IX
1999
38 Citations (Scopus)

Persistent delivery of factor IX in mice: Gene therapy for hemophilia using implantable microcapsules

Hortelano, G., Xu, N., Vandenberg, A., Solera, J., Chang, P. L. & Ofosu, F. A., May 20 1999, In : Human Gene Therapy. 10, 8, p. 1281-1288 8 p.

Research output: Contribution to journalArticle

Factor IX
Hemophilia A
Genetic Therapy
Capsules
Myoblasts
66 Citations (Scopus)

The in vivo delivery of heterologous proteins by microencapsulated recombinant cells

Chang, P. L., Van Raamsdonk, J. M., Hortelano, G., Barsoum, S. C., MacDonald, N. C. & Stockley, T. L., Feb 1 1999, In : Trends in Biotechnology. 17, 2, p. 78-83 6 p.

Research output: Contribution to journalArticle

Recombinant Proteins
Capsules
Proteins
Microencapsulation
Recombinant proteins
1998
101 Citations (Scopus)

Encapsulation of various recombinant mammalian cell types in different alginate microcapsules

Peirone, M., Ross, C. J. D., Hortelano, G., Brash, J. L. & Chang, P. L., Dec 15 1998, In : Journal of Biomedical Materials Research. 42, 4, p. 587-596 10 p.

Research output: Contribution to journalArticle

Alginate
Encapsulation
Capsules
Cells
Barium
1996
131 Citations (Scopus)

Delivery of human factor IX in mice by encapsulated recombinant myoblasts: A novel approach towards allogeneic gene therapy of hemophilia B

Hortelano, G., Al-Hendy, A., Ofosu, F. A. & Chang, P. L., Jun 15 1996, In : Blood. 87, 12, p. 5095-5103 9 p.

Research output: Contribution to journalArticle

Hemophilia B
Gene therapy
Factor IX
Myoblasts
Human engineering
38 Citations (Scopus)

Growth retardation - An unexpected outcome from growth hormone gene therapy in normal mice with microencapsulated myoblasts

Al-Hendy, A., Hortelano, G., Tannenbaum, G. S. & Chang, P. L., Jan 1 1996, In : Human Gene Therapy. 7, 1, p. 61-70 10 p.

Research output: Contribution to journalArticle

Myoblasts
Genetic Therapy
Growth Hormone
Growth
Pituitary Dwarfism
33 Citations (Scopus)

Permeability of alginate microcapsules to secretory recombinant gene products

Awrey, D. E., Tse, M., Hortelano, G. & Chang, P. L., Nov 20 1996, In : Biotechnology and Bioengineering. 52, 4, p. 472-484 13 p.

Research output: Contribution to journalArticle

Alginate
Capsules
Permeability
Genes
Gene therapy
1995
106 Citations (Scopus)

Correction of the growth defect in dwarf mice with nonautologous microencapsulated myoblasts - An alternate approach to somatic gene therapy

Al-Hendy, A., Hortelano, G., Tannenbaum, G. S. & Chang, P. L., Feb 1995, In : Human Gene Therapy. 6, 2, p. 165-175 11 p.

Research output: Contribution to journalArticle

Myoblasts
Genetic Therapy
Growth Hormone
Growth
Capsules
1994
49 Citations (Scopus)

Growth of recombinant fibroblasts in alginate microcapsules

Chang, P. L., Hortelano, G., Tse, M. & Awrey, D. E., 1994, In : Biotechnology and Bioengineering. 43, 10, p. 925-933 9 p.

Research output: Contribution to journalArticle

Alginate
Fibroblasts
Capsules
Hormones
Encapsulation