• 9230 Citations
  • 53 h-Index
1982 …2014

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Article
2012

Characterization of a novel oral glucocorticoid system and its possible role in disease

Cirillo, N., Hassona, Y., Pignatelli, M., Gasparoto, T. H., Morgan, D. J. & Prime, S. S., Jan 1 2012, In : Journal of Dental Research. 91, 1, p. 97-103 7 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Prevalence of different subtypes of serrated polyps and risk of synchronous advanced colorectal neoplasia in average-risk population undergoing first-time colonoscopy

Buda, A., De Bona, M., Dotti, I., Piselli, P., Zabeo, E., Barbazza, R., Bellumat, A., Valiante, F., Nardon, E., Probert, C. S., Pignatelli, M., Stanta, G., Sturniolo, G. C. & De Boni, M., Jun 11 2012, In : Clinical and Translational Gastroenterology. 3

Research output: Contribution to journalArticle

61 Citations (Scopus)
2011

E-cadherin and the cytoskeletal network in colorectal cancer development and metastasis

Buda, A. & Pignatelli, M., Dec 1 2011, In : Cell Communication and Adhesion. 18, 6, p. 133-143 11 p.

Research output: Contribution to journalArticle

46 Citations (Scopus)
1 Citation (Scopus)

The actin-bundling protein Fascin is overexpressed in inflammatory bowel disease and may be important in tissue repair

Qualtrough, D., Smallwood, K., Littlejohns, D. & Pignatelli, M., Feb 23 2011, In : BMC Gastroenterology. 11, 14.

Research output: Contribution to journalArticle

9 Citations (Scopus)
2010

Role of human tissue kallikrein in gastrointestinal stromal tumour invasion

Dominek, P., Campagnolo, P., H-Zadeh, M., Kränkel, N., Chilosi, M., Sharman, J. A., Caporali, A., Mangialardi, G., Spinetti, G., Emanueli, C., Pignatelli, M. & Madeddu, P., Oct 26 2010, In : British journal of cancer. 103, 9, p. 1422-1431 10 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)
2009

The actin-bundling protein fascin is overexpressed in colorectal adenomas and promotes motility in adenoma cells in vitro

Qualtrough, D., Singh, K., Banu, N., Paraskeva, C. & Pignatelli, M., 2009, In : British journal of cancer. 101, 7, p. 1124-1129 6 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)
2007

Inhibition of COX-2 with NS-398 decreases colon cancer cell motility through blocking epidermal growth factor receptor transactivation: Possibilities for combination therapy

Banu, N., Buda, A., Chell, S., Elder, D., Moorghen, M., Paraskeva, C., Qualtrough, D. & Pignatelli, M., Oct 2007, In : Cell Proliferation. 40, 5, p. 768-779 12 p.

Research output: Contribution to journalArticle

37 Citations (Scopus)
2006

Adult leydig cell tumors of the testis caused by germline fumarate hydratase mutations

Carvajal-Carmona, L. G., Alam, N. A., Pollard, P. J., Jones, A. M., Barclay, E., Wortham, N., Pignatelli, M., Freeman, A., Pomplun, S., Ellis, I., Poulsom, R., El-Bahrawy, M. A., Berney, D. M. & Tomlinson, I. P. M., 2006, In : Journal of Clinical Endocrinology and Metabolism. 91, 8, p. 3071-3075 5 p.

Research output: Contribution to journalArticle

78 Citations (Scopus)

Soluble IGF2 receptor rescues ApcMin/+ intestinal adenoma progression induced by Igf2 loss of imprinting

Harper, J., Burns, J. L., Foulstone, E. J., Pignatelli, M., Zaina, S. & Hassan, A. B., Feb 15 2006, In : Cancer Research. 66, 4, p. 1940-1948 9 p.

Research output: Contribution to journalArticle

53 Citations (Scopus)
2005

Activated Akt expression in breast cancer: Correlation with p53, Hdm2 and patient outcome

Vestey, S. B., Sen, C., Calder, C. J., Perks, C. M., Pignatelli, M. & Winters, Z. E., May 2005, In : European Journal of Cancer. 41, 7, p. 1017-1025 9 p.

Research output: Contribution to journalArticle

35 Citations (Scopus)
22 Citations (Scopus)

Laryngeal epithelial defenses against laryngopharyngeal reflux: Investigations of E-cadherin, carbonic anhydrase isoenzyme III, and pepsin

Gill, G. A., Johnston, N., Buda, A., Pignatelli, M., Pearson, J., Dettmar, P. W. & Koufman, J., Dec 2005, In : Annals of Otology, Rhinology and Laryngology. 114, 12 I, p. 913-921 9 p.

Research output: Contribution to journalArticle

72 Citations (Scopus)

Reduced p120ctn expression correlates with poor survival in patients with adenocarcinoma of the gastroesophageal junction

Wijnhoven, B. P. L., Pignatelli, M., Dinjens, W. N. M. & Tilanus, H. W., Nov 1 2005, In : Journal of Surgical Oncology. 92, 2, p. 116-123 8 p.

Research output: Contribution to journalArticle

38 Citations (Scopus)
2004

A Multicenter Phase I Gene Therapy Clinical Trial Involving Intraperitoneal Administration of E1A-Lipid Complex in Patients with Recurrent Epithelial Ovarian Cancer Overexpressing HER-2/neu Oncogene

Madhusudan, S., Tamir, A., Bates, N., Flanagan, E., Gore, M. E., Barton, D. P. J., Harper, P., Seckl, M., Thomas, H., Lemoine, N. R., Charnock, M., Habib, N. A., Lechler, R., Nicholls, J., Pignatelli, M. & Ganesan, T. S., May 1 2004, In : Clinical Cancer Research. 10, 9, p. 2986-2996 11 p.

Research output: Contribution to journalArticle

70 Citations (Scopus)

Biochemical analysis and subcellular distribution of E-cadherin-catenin in adenocarcinomas of the gastro-oesophageal junction

Wijnhoven, B. P. L., Tucker, E. T., Dinjens, W. N. M., Tilanus, H. W. & Pignatelli, M., May 1 2004, In : Anticancer Research. 24, 3 A, p. 1369-1375 7 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

p14ARF expression in invasive breast cancers and ductal carcinoma in situ- relationships to p53 and Hdm2

Vestey, S. B., Sen, C., Calder, C. J., Perks, C. M., Pignatelli, M. & Winters, Z. E., Jul 29 2004, In : Breast Cancer Research. 6, 5, R571.

Research output: Contribution to journalArticle

Open Access
17 Citations (Scopus)
2003

Abnormalities of the cadherin-catenin complex in chemically-induced colo-rectal carcinogenesis

Tucker, E., Buda, A., Janghra, N., Baker, J., Coad, J., Moorghan, M., Havler, M., Dettmar, P. & Pignatelli, M., Feb 2003, In : Proceedings of the Nutrition Society. 62, 1, p. 229-236 8 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Butyrate downregulates α2β1 integrin: A possible role in the induction of apoptosis in colorectal cancer cell lines

Buda, A., Qualtrough, D., Jepson, M. A., Martines, D., Paraskeva, C. & Pignatelli, M., May 1 2003, In : Gut. 52, 5, p. 729-734 6 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)

Cell biology of laryngeal epithelial defenses in health and disease: Further studies

Bulmer, D., Ross, P. E., Axford, S. E., Johnston, N., Gill, G. A., Pearson, J. P., Dettmar, P. W., Panetti, M., Pignatelli, M. & Koufman, J. A., Jun 1 2003, In : Annals of Otology, Rhinology and Laryngology. 112, 6, p. 481-491 11 p.

Research output: Contribution to journalArticle

137 Citations (Scopus)

Fascin, an actin-bundling protein, modulates colonic epithelial cell invasiveness and differentiation in vitro

Jawhari, A. U., Buda, A., Jenkins, M., Shehzad, K., Sarraf, C., Noda, M., Farthing, M. J. G., Pignatelli, M. & Adams, J. C., Jan 1 2003, In : American Journal of Pathology. 162, 1, p. 69-80 12 p.

Research output: Contribution to journalArticle

175 Citations (Scopus)
2002

Abnormal immunoreactivity of the E-cadherin/catenin (α-, β-, and γ-) complex in premalignant and malignant non-melanocytic skin tumours

Papadavid, E., Pignatelli, M., Zakynthinos, S., Krausz, T. & Chu, A. C., Feb 11 2002, In : Journal of Pathology. 196, 2, p. 154-162 9 p.

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abnormal α-catenin expression in invasive breast cancer correlates with poor patient survival

Nakopoulou, L., Gakiopoulou-Givalou, H., Karayiannakis, A. J., Giannopoulou, I., Keramopoulos, A., Davaris, P. & Pignatelli, M., Jun 22 2002, In : Histopathology. 40, 6, p. 536-546 11 p.

Research output: Contribution to journalArticle

59 Citations (Scopus)

β-catenin expression and allelic loss at APC in sporadic colorectal carcinogenesis

Hao, X., Frayling, I. M., Willcocks, T. C., Han, W., Tomlinson, I. P., Pignatelli, M. N., Pretlow, T. P. & Talbot, I. C., Apr 27 2002, In : Virchows Archiv. 440, 4, p. 362-366 5 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)
2001

Expression patterns of β-catenin in in situ and invasive breast cancer

Karayiannakis, A. J., Nakopoulou, L., Gakiopoulou, H., Keramopoulos, A., Davaris, P. S. & Pignatelli, M., Jan 1 2001, In : European Journal of Surgical Oncology. 27, 1, p. 31-36 6 p.

Research output: Contribution to journalArticle

58 Citations (Scopus)

FGF-1 and FGF-2 modulate the E-cadherin/catenin system in pancreatic adenocarcinoma cell lines

Ei-Hariry, I., Pignatelli, M. & Lemoine, N. R., Jun 15 2001, In : British journal of cancer. 84, 12, p. 1656-1663 8 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

FGF-1 and FGF-2 regulate the expression of E-cadherin and catenins in pancreatic adenocarcinoma

El-Hariry, I., Pignatelli, M. & Lemoine, N. R., Dec 1 2001, In : International Journal of Cancer. 94, 5, p. 652-661 10 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)

The potential role of abnormal E-cadherin and α-, β- and γ-catenin immunoreactivity in the determination of the biological behaviour of keratoacanthoma

Papadavid, E., Pignatelli, M., Zakynthinos, S., Krausz, T. & Chu, A. C., Dec 1 2001, In : British Journal of Dermatology. 145, 4, p. 582-589 8 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)
2000

E-cadherin-catenin cell-cell adhesion complex and human cancer

Wijnhoven, B. P. L., Dinjens, W. N. M. & Pignatelli, M., 2000, In : British Journal of Surgery. 87, 8, p. 992-1005 14 p.

Research output: Contribution to journalArticle

373 Citations (Scopus)

Epithelial mucin expression in bladder cancer: Correlation with pathological and clinical parameters

Syrigos, K. N., Deonarain, D. M., Karayiannakis, A., Waxman, J., Krausz, T. & Pignatelli, M., Jan 1 2000, In : Urological Research. 28, 4, p. 241-245 5 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Expression of the E-cadherin/catenin (α-, β-, and γ-) complex correlates with the macroscopic appearance of early gastric cancer

Ohene-Abuakwa, Y., Noda, M., Perenyi, M., Kobayashi, N., Kashima, K., Hattori, T. & Pignatelli, M., Dec 19 2000, In : Journal of Pathology. 192, 4, p. 433-439 7 p.

Research output: Contribution to journalArticle

44 Citations (Scopus)

Microsatellite instability and allelic imbalance in primary and secondary colorectal cancer

Schneider, A., Rohr, S., Kelly, M. D., Mitry, R., Pignatelli, M., Dore, C. J., Gaub, M. P., Jaeck, D., Meyer, C., Oudet, P. & Habib, N. A., Sep 4 2000, In : Australian and New Zealand Journal of Surgery. 70, 8, p. 587-592 6 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Source of oncofetal ED-B-containing fibronectin: Implications of production of both tumor and endothelial cells

Midulla, M., Verma, R., Pignatelli, M., Ritter, M. A., Courtenay-Luck, N. S. & George, A. J. T., Jan 1 2000, In : Cancer Research. 60, 1, p. 164-169 6 p.

Research output: Contribution to journalArticle

56 Citations (Scopus)

Systemic effect of peanut agglutinin following intravenous infusion into rats

Jordinson, M., Fitzgerald, A. J., Goodlad, R. A., Brynes, A., Grant, G., Pignatelli, M. & Calam, J., Jun 26 2000, In : Alimentary Pharmacology and Therapeutics. 14, 6, p. 835-840 6 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)
1999

Abnormal expression and function of the E-cadherin-catenin complex in gastric carcinoma cell lines

Jawhari, A. U., Noda, M., Farthing, M. J. G. & Pignatelli, M., Jan 1 1999, In : British journal of cancer. 80, 3-4, p. 322-330 9 p.

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abnormal expression of the E-cadherin-catenin complex in dysplastic Barrett's oesophagus

Seery, J. P., Syrigos, K. N., Karayiannakis, A. J., Valizadeh, A. & Pignatelli, M., Dec 10 1999, In : Acta Oncologica. 38, 7, p. 945-948 4 p.

Research output: Contribution to journalArticle

33 Citations (Scopus)

An analysis of site-specific attributable pathologies for colorectal symptoms: Diagnostic yield of colonoscopy

Zbar, A. P., Pignatelli, M., Sherman, D., Toomey, P. & Kmiot, W. A., 1999, In : Colorectal Disease. 1, 4, p. 234-237 4 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Cadherin-catenin expression in primary colorectal cancer: A survival analysis

Hugh, T. J., Dillon, S. A., Taylor, B. A., Pignatelli, M., Poston, G. J. & Kinsella, A. R., May 29 1999, In : British journal of cancer. 80, 7, p. 1046-1051 6 p.

Research output: Contribution to journalArticle

111 Citations (Scopus)

Characterization of the E-cadherin-catenin complexes in pancreatic carcinoma cell lines

El-Hariry, I., Jordinson, M., Lemoine, N. & Pignatelli, M., Jun 10 1999, In : Journal of Pathology. 188, 2, p. 155-162 8 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Clinical short-term results of radiofrequency ablation in primary and secondary liver tumors

Jiao, L. R., Hansen, P. D., Havlík, R., Mitry, R. R., Pignatelli, M. & Habib, N., Apr 1 1999, In : American Journal of Surgery. 177, 4, p. 303-306 4 p.

Research output: Contribution to journalArticle

231 Citations (Scopus)

Expression patterns of the novel catenin p120cas in gastrointestinal cancers

Karayiannakis, A. J., Syrigos, K. N., Alexiou, D., Kalahanis, N., Rosenberg, T., Bastounis, E. & Pignatelli, M., Dec 1 1999, In : Anticancer Research. 19, 5 C, p. 4401-4405 5 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Gastrointestinal responses to a panel of lectins in rats maintained on total parenteral nutrition

Jordinson, M., Goodlad, R. A., Brynes, A., Bliss, P., Ghatei, M. A., Bloom, S. R., Fitzgerald, A., Grant, G., Bardocz, S., Pusztai, A., Pignatelli, M. & Calam, J., May 1 1999, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 276, 5 39-5, p. G1235-G1242

Research output: Contribution to journalArticle

36 Citations (Scopus)

Mutated epithelial cadherin is associated with increased tumorigenicity and loss of adhesion and of responsiveness to the motogenic trefoil factor 2 in colon carcinoma cells

Efstathiou, J. A., Liu, D., Wheeler, J. M. D., Kim, H. C., Beck, N. E., Ilyas, M., Karayiannakis, A. J., Mortensen, N. J. M. C., Kmiot, W., Playford, R. J., Pignatelli, M. & Bodmer, W. F., Mar 2 1999, In : Proceedings of the National Academy of Sciences of the United States of America. 96, 5, p. 2316-2321 6 p.

Research output: Contribution to journalArticle

95 Citations (Scopus)
Open Access
2 Citations (Scopus)

Up-regulated cytoplasmic expression, with reduced membranous distribution, of the src substrate p120(ctn) in gastric carcinoma

Jawhari, A. U., Noda, M., Pignatelli, M. & Farthing, M., Oct 4 1999, In : Journal of Pathology. 189, 2, p. 180-185 6 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)

Vicia faba agglutinin, the lectin present in broad beans, stimulates differentiation of undifferentiated colon cancer cells

Jordinson, M., El-Hariry, I., Calnan, D., Calam, J. & Pignatelli, M., 1999, In : Gut. 44, 5, p. 709-714 6 p.

Research output: Contribution to journalArticle

Open Access
53 Citations (Scopus)

β-Catenin expression in primary and metastatic colorectal carcinoma

Hugh, T. J., Dillon, S. A., O'Dowd, G., Getty, B., Pignatelli, M., Poston, G. J. & Kinsella, A. R., Aug 2 1999, In : International Journal of Cancer. 82, 4, p. 504-511 8 p.

Research output: Contribution to journalArticle

96 Citations (Scopus)
1998

Abnormal expression of p120 correlates with poor survival in patients with bladder cancer

Syrigos, K. N., Karayiannakis, A., Syrigou, E. I., Harrington, K. & Pignatelli, M., Dec 1 1998, In : European Journal of Cancer. 34, 13, p. 2037-2040 4 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)

Altered γ-catenin expression correlates with poor survival in patients with bladder cancer

Syrigos, K. N., Harrington, K., Waxman, J., Krausz, T. & Pignatelli, M., Nov 1998, In : Journal of Urology. 160, 5, p. 1889-1893 5 p.

Research output: Contribution to journalArticle

63 Citations (Scopus)

Comparison of endoanal magnetic resonance imaging and computerized tomography in the preoperative staging of rectal cancer: A pilot study

Zbar, A. P., DeSouza, N. M., Strickland, N., Pignatelli, M. & Kmiot, W. A., Dec 1 1998, In : Techniques in Coloproctology. 2, 2, p. 61-66 6 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)