Mohamad Aljofan, PhD

Assistant Professor

Former affiliations

Accepting PhD Students

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20072022

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Personal profile

Personal profile

Dr. Mohamad Aljofan graduated with a BSc (Pharmaceutical Sciences) (Honors) from the Royal Melbourne Institute of Technology Melbourne (Australia). He has a Master’s Degree in Clinical Pharmacy and a PhD in drug discovery that was conducted at Australia’s highest research institute “The Commonwealth Scientific and Industrial Research Organisation”. Dr. Aljofan did his Postdoctoral training at Prince Henry’s Institute of Medical Research and the School of Medicine, Nursing and Health Sciences at Monash University- Australia. After, he became the Vice Dean and Department Chair of Clinical Pharmacy at the University of Hail in Saudi Arabia where he established his mixed Clinical and Basic research group. His Clinical research focuses on medication adherence and public health and his Basic research interests revolve around drug discovery and development, particularly early drug discovery. Dr. Aljofan received several research grants and funding from different sources including the National Health and Medical Research Council of Australia, Monash University, University of Hail and KACST in Saudi Arabia. He is a recipient of many awards and recognitions including the prestigious Australian NHMRC- Postdoctoral Fellowship, CSIRO-Postgraduate Scholarship and RMIT Undergraduate Scholarship.

 

Research interests

Biomedical Research: Drug Discovery and Development

Clinical Research:

1) Medication adherence

2) Vaccine hesitancy 

Publications

Biomedical Research:

Antiproliferative and cytotoxic activity of Geraniaceae plant extracts against five tumor cell lines

Sergazy, S., Vetrova, A., Orhan, I. E., Senol Deniz, F. S., Kahraman, A., Zhang, J. Y. & Aljofan, M., Feb 2022, In: Future Science OA. 8, 2, FSO775.

 

Therapeutic Potential of Metabolites from Lactobacillus rhamnosus and Mare's Milk in the Treatment of Dysbiosis

Kozhakhmetov, S., Babenko, D., Kozhakhmetova, S., Tuyakova, A., Nurgaziyev, M., Nurgozhina, A., Muhanbetganov, N., Chulenbayeva, L., Sergazy, S., Gulyayev, A., Aljofan, M. & Kushugulova, A., 2022, In: BioMed Research International. 2022, 3851478.

 

Antiradical and Cytoprotective Properties of Allium nutans L. Honey Against CCL4-Induced Liver Damage in Rats

Sergazy, S., Gulyayev, A., Amangeldiyeva, A., Nurgozhina, A., Nurgaziyev, M., Shulgau, Z., Chulenbayeva, L., Khassenbekova, Z., Kushugulova, A. & Aljofan, M., Sep 20 2021, In: Frontiers in Pharmacology. 12, 687763.

Cardioprotective effect of grape polyphenol extract against doxorubicin induced cardiotoxicity

Sergazy, S., Shulgau, Z., Fedotovskikh, G., Chulenbayeva, L., Nurgozhina, A., Nurgaziyev, M., Krivyh, E., Kamyshanskiy, Y., Kushugulova, A., Gulyayev, A. & Aljofan, M., Dec 1 2020, In: Scientific Reports. 10, 1, 14720.

An overview of drug discovery and development

Berdigaliyev, N. & Aljofan, M., Apr 9 2020, In: Future Medicinal Chemistry.

 

Development and validation of a simple and sensitive HPLC method for the determination of liquid form of therapeutic substances

Alkhamaisah, S. I., Younes, K. M., Gaipov, A. & Aljofan, M., Jan 1 2019, In: Electronic Journal of General Medicine. 16, 6, em166.

 

Anticancer activity of metformin: A systematic review of the literature

Aljofan, M. & Riethmacher, D., 2019, In: Future Science OA. 5, 8, FSO410.

 

Acute toxicity testing of newly discovered potential antihepatitis B virus agents of plant origin

Subaiea, G. M., Aljofan, M., Devadasu, V. R. & Alshammari, T. M., Nov 2017, In: Asian Journal of Pharmaceutical and Clinical Research. 10, 11, p. 210-213 4 p.

 

Comparison of different serum sample extraction methods and their suitability for mass spectrometry analysis

Alshammari, T. M., Al-Hassan, A. A., Hadda, T. B. & Aljofan, M., Nov 1 2015, In: Saudi Pharmaceutical Journal. 23, 6, p. 689-697 9 p.

 

POM analyses of Raltegravir derivatives: A new reflection enlightening the mechanism of HIV-integrase inhibition

Lahsasni, S., Ben Hadda, T., Masand, V., Pathan, N. B., Parvez, A., Warad, I., Shaheen, U., Bader, A. & Aljofan, M., Aug 2 2015, In: Research on Chemical Intermediates. 41, 8, p. 5121-5136 16 p.

 

Genotyping, morphology and molecular characteristics of a lytic phage of Neisseria strain obtained from infected human dental plaque

Aljarbou, A. N. & Aljofan, M., Jun 2014, In: Journal of Microbiology. 52, 7, p. 609-618 10 p.

 

Anti-hepatitis B activity of isoquinoline alkaloids of plant origin

Aljofan, M., Netter, H. J., Aljarbou, A. N., Hadda, T. B., Orhan, I. E., Sener, B. & Mungall, B. A., May 2014, In: Archives of Virology. 159, 5, p. 1119-1128 10 p.

 

Synthesis, characterization, bioactivity, and POM analyses of isothiochromeno[3,4-e][1,2]oxazines

Bennani, B., Kerbal, A., Baba, B. F., Daoudi, M., Warad, I., Aljofan, M., Alafeefy, A. M., Masand, V. & Hadda, T. B., Oct 1 2013, In: Medicinal Chemistry Research. 22, 10, p. 4798-4809 12 p.

 

Cleavage of endometrial α-integrins into their functional forms is mediated by proprotein convertase 5/6

Paule, S., Aljofan, M., Simon, C., Rombauts, L. J. F. & Nie, G., Sep 2012, In: Human Reproduction. 27, 9, p. 2766-2774 9 p.

 

Inhibition of proprotein convertase 5/6 activity: Potential for nonhormonal women-centered contraception

Aljofan, M., Singh, H., Ho, H., Xie, S., Zhu, Y., Sun, Z., Guo, X., Wang, J. & Nie, G., Jun 1 2012, In: Contraception. 85, 6, p. 602-610 9 p.

 

A high-throughput in vitro model of human embryo attachment

Ho, H., Singh, H., Aljofan, M. & Nie, G., Apr 1 2012, In: Fertility and Sterility. 97, 4, p. 974-978 5 p.

 

 

PTOV1 is associated with UCH-L1 and in response to estrogen stimuli during the mouse oocyte development

Yao, Y. W., Shi, Y., Jia, Z. F., Jiang, Y. H., Gu, Z., Wang, J., Aljofan, M. & Sun, Z. G., Aug 1 2011, In: Histochemistry and Cell Biology. 136, 2, p. 205-215 11 p.

 

Characterization of the antiviral and inflammatory responses against Nipah virus in endothelial cells and neurons

Lo, M. K., Miller, D., Aljofan, M., Mungall, B. A., Rollin, P. E., Bellini, W. J. & Rota, P. A., Aug 1 2010, In: Virology. 404, 1, p. 78-88 11 p.

 

Off label antiviral therapeutics for henipaviruses: New light through old windows

Aljofan, M., Lo, M. K., Rota, P. A., Michalski, W. P. & Mungall, B. A., Jul 22 2010, In: Journal of Antivirals and Antiretrovirals. 2, 1, p. 1-10 10 p.

 

Viral entry inhibitors targeted to the membrane site of action

Porotto, M., Yokoyama, C. C., Palermo, L. M., Mungall, B., Aljofan, M., Cortese, R., Pessi, A. & Moscona, A., Jul 1 2010, In: Journal of Virology. 84, 13, p. 6760-6768 9 p.

 

High glucose increases expression of cyclooxygenase-2, increases oxidative stress and decreases the generation of nitric oxide in mouse microvessel endothelial cells

Aljofan, M. & Ding, H., Mar 1 2010, In: Journal of Cellular Physiology. 222, 3, p. 669-675 7 p.

 

Antiviral activity of gliotoxin, gentian violet and brilliant green against Nipah and Hendra virus in vitro

Aljofan, M., Sganga, M. L., Lo, M. K., Rootes, C. L., Porotto, M., Meyer, A. G., Saubern, S., Moscona, A. & Mungall, B. A., Dec 1 2009, In: Virology Journal. 6, 187.

 

Kinetic dependence of paramyxovirus entry inhibition

Porotto, M., Yokoyama, C. C., Orefice, G., Kim, H. S., Aljofan, M., Mungall, B. A. & Moscona, A., Jul 1 2009, In: Journal of Virology. 83, 13, p. 6947-6951 5 p.

 

Characteristics of Nipah virus and Hendra virus replication in different cell lines and their suitability for antiviral screening

Aljofan, M., Saubern, S., Meyer, A. G., Marsh, G., Meers, J. & Mungall, B. A., Jun 1 2009, In: Virus Research. 142, 1-2, p. 92-99 8 p.

 

Simulating henipavirus multicycle replication in a screening assay leads to identification of a promising candidate for therapy

Porotto, M., Orefice, G., Yokoyama, C. C., Mungall, B. A., Realubit, R., Sganga, M. L., Aljofan, M., Whitt, M., Glickman, F. & Moscona, A., May 1 2009, In: Journal of Virology. 83, 10, p. 5148-5155 8 p.

 

Development and validation of a chemiluminescent immunodetection assay amenable to high throughput screening of antiviral drugs for Nipah and Hendra virus

Aljofan, M., Porotto, M., Moscona, A. & Mungall, B. A., Apr 1 2008, In: Journal of Virological Methods. 149, 1, p. 12-19 8 p.

 

Oxidative stress and increased eNOS and NADPH oxidase expression in mouse microvessel endothelial cells

Ding, H., Aljofan, M. & Triggle, C. R., Sep 1 2007, In: Journal of Cellular Physiology. 212, 3, p. 682-689 8 p.

 

Clinical Research:

The Potential Role of Extracellular Vesicles in COVID-19 Treatment: Opportunity and Challenge

Yan, Y. Y., Zhou, W. M., Wang, Y. Q., Guo, Q. R., Zhao, F. X., Zhu, Z. Y., Xing, Y. X., Zhang, H. Y., Aljofan, M., Jarrahi, A. M., Makabel, B. & Zhang, J. Y., Jul 21 2021, In: Frontiers in Molecular Biosciences. 8, 699929.

 

Knowledge, attitude, and practice toward COVID-19 vaccination in Kazakhstan: a cross-sectional study

Issanov, A., Akhmetzhanova, Z., Riethmacher, D. & Aljofan, M., 2021, (Accepted/In press) In: Human Vaccines and Immunotherapeutics. 17, 10, p. 3394-3400 7 p.

 

Short-term effect of ldl-apheresis on lipid profile of patients with nephrotic and non-nephrotic hyperlipidemia: A comparative study

Gaipov, A., Nogaibayeva, A., Turebekov, Z., Zharmukhanbet, L., Orazbayev, G., Malykh, D., Kim, N., Abbay, A., Tuganbekova, S., Aljofan, M. & Bekishev, B., 2021, In: Electronic Journal of General Medicine. 18, 3, em295.

 

Covid-19 treatment: The race against time

Aljofan, M. & Gaipov, A., Dec 2020, In: Electronic Journal of General Medicine. 17, 6, em227.

 

Clinical evidences on the antiviral properties of macrolide antibiotics in the COVID-19 era and beyond

Poddighe, D. & Aljofan, M., Sep 26 2020, In: Antiviral Chemistry and Chemotherapy. 28, p. 2040206620961712

 

Epidemiology of dialysis-treated end-stage renal disease patients in Kazakhstan: data from nationwide large-scale registry 2014-2018

Gaipov, A., Issanov, A., Kadyrzhanuly, K., Galiyeva, D., Khvan, M., Aljofan, M., Molnar, M. Z. & Kovesdy, C. P., Sep 21 2020, In: BMC Nephrology. 21, 1, p. 407

 

COVID-19 Outbreak in Post-Soviet States: Modeling the Best and Worst Possible Scenarios

Issanov, A., Amanbek, Y., Abbay, A., Adambekov, S., Aljofan, M., Kashkynbayev, A. & Gaipov, A., Jun 1 2020, In: Electronic Journal of General Medicine. 18, 1, p. em21001

 

Dose equivalency and efficacy of biosimilar erythropoietin stimulating agents: Data from real clinical practice

Gaipov, A., Issanov, A., Mursalova, Z., Tulegenova, N., Kakim, Z., Baizakov, M., Tuganbekova, S. & Aljofan, M., Jun 2020, In: Pharmacology Research and Perspectives. 8, 3, p. e00594

 

Vaccine adherence: the rate of hesitancy toward childhood immunization in Kazakhstan

Akhmetzhanova, Z., Sazonov, V., Riethmacher, D. & Aljofan, M., Jun 2020, In: Expert Review of Vaccines. 19, 6, p. 579-584 6 p.

 

Association of medication storage with diabetes control: A cross-sectional study from Saudi Arabia

Altebainawi, A. F., Alrashidi, M. N., Aljbreen, M. K., Aziz, M. M., Alhifany, A. A., Aljofan, M. & Alshammari, T. M., Apr 2020, In: Saudi Pharmaceutical Journal. 28, 4, p. 452-459 8 p.

 

Prevalence and factors influencing use of herbal medicines during pregnancy in hail, Saudi Arabia a cross-sectional study

Aljofan, M. & Alkhamaiseh, S., Feb 2020, In: Sultan Qaboos University Medical Journal. 20, 1, p. e71-e76

 

Chloroquine and COVID-19: A light at the end of the tunnel, or is it another train?

Aljofan, M. & Gaipov, A., Jan 1 2020, In: Electronic Journal of General Medicine. 17, 4, em207.

 

Prevalence of use and reported side effects of herbal medicine among adults in Saudi Arabia

Alkhamaisah, S. & Aljofan, M., 2020, Complementary Therapies in Medicine, 102255.

 

 

Vaccine adherence: the rate of hesitancy toward childhood immunization in Kazakhstan

Akhmetzhanova, Z., Sazonov, V., Riethmacher, D. & Aljofan, M., 2020, In: Expert Review of Vaccines.

 

Knowledge, awareness, attitude, and practice of health-care professionals toward hepatitis B disease and vaccination in Saudi Arabia

Alshammari, T. M., Aljofan, M., Subaie, G. & Hussain, T., Dec 2 2019, In: Human Vaccines and Immunotherapeutics. 15, 12, p. 2816-2823 8 p.

 

Public knowledge, attitude and practice toward diabetes mellitus in hail region, Saudi Arabia

Aljofan, M., Altebainawi, A. & Alrashidi, M. N., Jan 1 2019, In: International Journal of General Medicine. 12, p. 255-262 8 p.

 

Pharmacy Malpractice: The rate and prevalence of dispensing high-risk prescription-only medications at community pharmacies in Saudi Arabia

Alshammari, T. M., Alhindi, S. A., Alrashdi, A. M., Benmerzouga, I. & Aljofan, M., Jul 2017, In: Saudi Pharmaceutical Journal. 25, 5, p. 709-714 6 p.

 

Completeness of medication prescriptions: Prescription errors study in Hail region, Saudi Arabia (PeSHR)

Altebainawi, A., Alrashidi, MM., Alshammari, TM. & Aljofan, M., 2019, In: Journal of Evidence-Based Psychotherapies.

 

Practices of patients consuming antibiotics and knowledge about antibiotic resistance in Hail region–Saudi Arabia

BenMarzouqa, I., Al-Zammay, S., Alshammari, MM., Alsaif, S. & Aljofan, M., 2019, In: Future Science OA. 420

 

Current advances in the utilization of nanotechnology for the diagnosis and treatment of diabetes

Devadasu, V. R., Alshammari, T. M. & Aljofan, M., Jan 1 2018, In: International Journal of Diabetes in Developing Countries. 38, 1, p. 11-19 9 p.

 

 

Editorials:

Editorial: New lights Through Old Windows: Metformin and Derivatives as Anti-Cancer Treatments

Moldasheva, A., Surov, V. & Aljofan, M., Apr 26 2022, In: Frontiers in Pharmacology. 13, 889642.

Metformin: A stroke of luck

Aljofan, M. & Gaipov, A., Jan 1 2019, In: Electronic Journal of General Medicine. 16, 3, em143.

Henipaviruses are not yet history

Aljofan, M., May 1 2015, In: Future Virology. 10, 5, p. 507-515 9 p.

 

Hendra and Nipah infection: Emerging paramyxoviruses

Aljofan, M., Nov 6 2013, In: Virus Research. 177, 2, p. 119-126 8 p.

The Era of scientific blossom

Aljofan, M., Jan 1 2012, In: Journal of Antivirals and Antiretrovirals. 4, 1, p. ii-iii

 

Education/Academic qualification

Drug Discovery , PhD

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