Projects per year
Personal profile
Research Interests
We are interested in deciphering the molecular mechanisms that drive carcinogenesis and metastasis. We are particularly focused on the role of p53, which is deemed as the major tumour suppressor in humans.
Teaching
Currently, I am teaching Bioethics; Fuel Metabolism; Immunology
Publications
https://pubmed.ncbi.nlm.nih.gov/?term=Barlev+N&sort=pubdate
Professional Information
Editor of Springer-Nature journals: Cell Death Disease (IF=9), Cell Death Discovery (IF=6).
Education/Academic qualification
molecular biology, PhD, The role of HSF in heat shock response, Aarhus University
Award Date: Mar 14 1994
External positions
Professor
Sept 1 2022 → …
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Projects
- 4 Active
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Patient derived lung cancer explants as a platform for validation of the correlation between CD320 and mutant p53
Lezina, L. (PI), Barlev, N. (Other Faculty/Researcher) & Gushchin, D. (Other Faculty/Researcher)
1/1/24 → 12/31/26
Project: FDCRGP
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Molecular mechanisms of solid cancer resistance to INFg/TNFa cytokines secreted by CAR-T cells
Barlev, N. (PI), Begimbetova, D. (Co-PI) & Makishev, A. (Co-PI)
1/1/24 → 12/31/26
Project: CRP
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Dissecting Zeb1-mediated regulation of p53 during epithelial-mesenchymal transition (EMT) in cancer
Barlev, N. (PI) & Tulchinsky, E. (Co-PI)
1/1/23 → 12/31/25
Project: FDCRGP
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Comprehensive analysis of cellular metrics: From proliferation to mitochondrial membrane potential and cell death in a single sample
Sabirova, S., Sharapova, G., Budyukova, A., Gomzikova, M., Brichkina, A., Barlev, N. A., Rizvanov, A., Markov, N. & Simon, H. U., Dec 2025, In: Cell Death Discovery. 11, 1, 119.Research output: Contribution to journal › Article › peer-review
Open Access1 Citation (Scopus) -
Dualistic role of ZEB1 and ZEB2 in tumor progression
Parfenyev, S. E., Daks, A. A., Shuvalov, O. Y., Fedorova, O. A., Pestov, N. B., Korneenko, T. V. & Barlev, N. A., Dec 2025, In: Biology Direct. 20, 1, 32.Research output: Contribution to journal › Review article › peer-review
Open Access1 Citation (Scopus) -
Effects of n-Myc and c-Myc on the expression of p53 family members and their transcriptional targets in human neuroblastoma cells
Nazarov, A., Parfenyev, S., Shuvalov, O., Frolova, K., Naminat, E., Nevzorov, I., Petukhov, A., Karpova, N., Fedorova, O., Barlev, N. & Daks, A., Jul 8 2025, In: Biochemical and Biophysical Research Communications. 769, 151944.Research output: Contribution to journal › Article › peer-review
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MDM2 up-regulates the energy metabolism in NSCLC in a p53-independent manner
Fefilova, E., Kirdeeva, Y., Parfenyev, S., Daks, A., Fedorova, O., Sorokina, M., Ha, N. X., Huong, T. T., Loc, V. T., Hai, P. T., Cuong, N. M., Barlev, N. & Shuvalov, O., Jan 2025, In: Biochemical and Biophysical Research Communications. 743, 151169.Research output: Contribution to journal › Article › peer-review
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Mitochondrial, metabolic and bioenergetic adaptations drive plasticity of colorectal cancer cells and shape their chemosensitivity
Markov, N., Sabirova, S., Sharapova, G., Gomzikova, M., Brichkina, A., Barlev, N. A., Egger, M., Rizvanov, A. & Simon, H. U., Dec 2025, In: Cell Death and Disease. 16, 1, 253.Research output: Contribution to journal › Article › peer-review
Open Access