• 6082 Citations
  • 43 h-Index
1987 …2020
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Personal profile

Professional Information

Professor Singh’s group works on fundamental mechanism of epigenetics. His aim is to dissect the reprogramming process and his recent work has shown that “age” reprogramming, where the age of an old cell is “re-set”, is separable from “developmental” reprogramming where the specialized functions of a cell are “wiped clean” and returned back to an embryonic, pluripotent, state. His group is working towards developing technologies for rejuvenating cells without the need to pass through an embryonic stage, which is obligatory using current methods of rejuvenating cell function.

External positions

Fingerprint Dive into the research topics where Prim Singh is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

Heterochromatin Medicine & Life Sciences
Chromatin Medicine & Life Sciences
Histones Medicine & Life Sciences
Proteins Medicine & Life Sciences
Epigenomics Medicine & Life Sciences
Genes Medicine & Life Sciences
Histone Code Medicine & Life Sciences
Lysine Medicine & Life Sciences

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Projects 2018 2020

Histone Code
Proteins
DNA Methylation
Mammals
Genes

Research Output 1987 2017

  • 6082 Citations
  • 43 h-Index
  • 72 Article
  • 16 Review article
1 Citation (Scopus)

Activity-DEPendent Transposition

Newman, A. G., Bessa, P., Tarabykin, V. & Singh, P. B., Mar 2017, In : EMBO Reports. 18, 3, p. 346-348 3 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

An HP1 isoform-specific feedback mechanism regulates Suv39h1 activity under stress conditions

Raurell-Vila, H., Bosch-Presegue, L., Gonzalez, J., Kane-Goldsmith, N., Casal, C., Brown, J. P., Marazuela-Duque, A., Singh, P. B., Serrano, L. & Vaquero, A., Feb 2017, In : Epigenetics. 12, 2, p. 166-175 10 p.

Research output: Contribution to journalArticle

Protein Isoforms
Heterochromatin
Protein Stability
heterochromatin-specific nonhistone chromosomal protein HP-1
Up-Regulation
9 Citations (Scopus)

Mammalian HP1 Isoforms Have Specific Roles in Heterochromatin Structure and Organization

Bosch-Presegué, L., Raurell-Vila, H., Thackray, J. K., González, J., Casal, C., Kane-Goldsmith, N., Vizoso, M., Brown, J. P., Gómez, A., Ausió, J., Zimmermann, T., Esteller, M., Schotta, G., Singh, P. B., Serrano, L. & Vaquero, A., Nov 21 2017, In : Cell Reports. 21, 8, p. 2048-2057 10 p.

Research output: Contribution to journalArticle

Heterochromatin
Protein Isoforms
Genes
Chromatin
Genomic Instability

Heterochromatin and the molecular mechanisms of 'parent-of-origin' effects in animals

Singh, P. B., Dec 2016, In : Journal of Biosciences. 41, 4, p. 759-786 28 p.

Research output: Contribution to journalReview article

Mammals
Heterochromatin
heterochromatin
Chromosomes
Gene expression

A hypomorphic Cbx3 allele causes prenatal growth restriction and perinatal energy homeostasis defects

Aydin, E., Kloos, D-P., Gay, E., Jonker, W., Hu, L., Bullwinkel, J., Brown, J. P., Manukyan, M., Giera, M., Singh, P. B. & Fundele, R., Jun 2015, In : Journal of Biosciences. 40, 2, p. 325-38 14 p.

Research output: Contribution to journalArticle

prenatal development
homeostasis
Homeostasis
Brown Adipose Tissue
brown adipose tissue