Dr. Yegorov's research aims to provide a better understanding of infectious diseases, offering insights that could lead to more effective methods of infection diagnosis and treatment. Dr. Yegorov's research focuses on three main areas:
1) Investigating pathogenic causes of respiratory infections;
2) Antimicrobial resistance in bacterial pneumonia and other related conditions;
3) Efficacy and effectiveness of vaccines against infectious diseases.

Dr. Yegorov’s lab applies state-of-the-art bioinformatics and statistical approaches to analyze complex immunological and molecular data. This research integrates next-generation sequencing pipelines for genome assembly, variant detection, and functional annotation of pathogenic bacteria and viruses, combining clinical and computational datasets to generate insights with implications for public health in Kazakhstan and worldwide.

Research highlights

1    Yegorov S, Brewer A, Cyr L, et al. Hemagglutination-Inhibition Antibodies and Protection against Influenza Elicited by Inactivated and Live Attenuated Vaccines in Children. The Journal of Infectious Diseases 2024.

2    Yegorov S, Celeste DB, Gomes KB, et al. Inactivated and live-attenuated seasonal influenza vaccines boost broadly neutralizing antibodies in children. Cell Reports Medicine 2022.

3    Yegorov S, Goremykina M, Ivanova R, et al. Epidemiology, clinical characteristics, and virologic features of COVID-19 patients in Kazakhstan: A nation-wide retrospective cohort study. The Lancet Regional Health – Europe 2021.

4    Yegorov S, Joag V, Galiwango RM, et al. Schistosoma mansoni treatment reduces HIV entry into cervical CD4+ T cells and induces IFN-I pathways. Nature Communications 2019.