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Tri studies mathematics, physics, and aerospace engineering through a Double Degree program in Advanced Science and Engineering at the University of Sydney, Australia. He then obtained a Ph.D. in Chemical Engineering, majoring in computational biophysics at Monash University, Australia.
After completing his Ph.D., Tri joined Professor Michael Shirts at the University of Virginia, USA, to train in computer-aided drug design by improving the efficiency and accuracy of free energy calculations for protein-ligand interactions. He has identified an optimal variance pathway that can reduce the total variance by 30% compare to the standard pathway. This finding facilitated computational drug design by providing a rapid and accurate method for free energy calculations.
In 2012, Tri received a prestige award (SystemsX.ch Transition Postdoc Fellowship) from the Swiss National Science Foundation to investigate the mechanics of asymmetric cell division (ACD) in Professor Clemens Cabernard’s laboratory at the Biozentrum, University of Basel. In Basel, he joined forces with Professor Daniel Müller’s laboratory at ETH Zürich to use atomic force microscopy (AFM) combining with live-cell imaging to measure hydrostatic pressure and cortical stiffness of a single cell at precise space and time during mitosis. He showed that ACD is a two-step process governed by asynchronous Myosin relocalization and internal pressure. He further showed that intracellular pressure plays an important role in enhancing the physical asymmetry in asymmetrically dividing cells. He also developed various methods and toolkits to facilitate the efficient analysis of a large amount of live and fixed cell imaging datasets. He joined the Department of Biology as an Assistant Professor in August 2019.
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Collaborations and top research areas from the last five years
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Establishing a fast, efficient and reliable platform for assessing the toxicity and efficacy of therapeutic drugs and nanoparticles
Pham, T. (PI), Poulopoulos, S. (Other Faculty/Researcher) & Atabaev, T. (Other Faculty/Researcher)
2/4/25 → 12/31/27
Project: FDCRGP
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AXL receptor in bladder cancer: on the crossroad between mechanotransduction and RTK signalling
Kriajevskaia, M. (PI), Pham, T. (Co-PI) & Berillo, D. (Co-PI)
1/1/25 → 12/31/27
Project: CRP
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The role of the interaction of organosilica nanoparticles with biological systems via live cell imaging and the effect of PEGylation.
Mun, E. (PI), Pham, T. (Other Faculty/Researcher) & Khutoryanskiy, V. (Other Faculty/Researcher)
1/1/24 → 12/31/26
Project: FDCRGP
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Valorization of local kaolin as adsorbent and catalyst for water/wastewater treatment
Poulopoulos, S. (PI), Golman, B. (Other Faculty/Researcher), Pham, T. (Other Faculty/Researcher) & Kyzas, G. Z. (Other Faculty/Researcher)
1/1/24 → 12/31/26
Project: FDCRGP
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AD-LOC: Development of bio-ionic-transistors integrated with a microfluidic chip as an advanced lab-on-a-chip device for biomedical applications
Pham, T. (PI)
1/1/24 → 12/31/26
Project: Government
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A comprehensive analysis of the impacts of Image Resolution and Scanning Times on the quality of MPI-reconstructed images
Do, T. D., Mukhatov, A., Tolebay, A., Le, T. A. & Pham, T. T., Feb 14 2025, In: Scientific Reports. 15, 1, p. 5519 1 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Citation (Scopus) -
Bridging prediction and reality: Comprehensive analysis of experimental and AlphaFold 2 full-length nuclear receptor structures
Mazhibiyeva, A., Pham, T. T., Pats, K., Lukac, M. & Molnár, F., Jan 2025, In: Computational and Structural Biotechnology Journal. 27, p. 1998-2013 16 p.Research output: Contribution to journal › Article › peer-review
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Chitosan-DNA nanoparticles: synthesis and optimization for long-term storage and effective delivery
Raimbekova, A., Kart, U., Yerishova, A., Elebessov, T., Yegorov, S., Pham, T. T. & Hortelano, G., 2025, In: PeerJ. 13, 1, 18750.Research output: Contribution to journal › Article › peer-review
Open Access1 Citation (Scopus) -
Comparative Investigation of Synthetic and Novel Natural Surfactants' Role in Oil Emulsion Creation
Kubasheva, A., Tuyakova, A., Zhuniskenov, Y., Serikov, G., Pham, T. T. & Abbas, A. H., 2025, Society of Petroleum Engineers - GOTECH 2025. Society of Petroleum Engineers, (Society of Petroleum Engineers - GOTECH 2025).Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
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Controlling the Growth of Cs2PbX4 Nanostructures Enhances the Stability of Inorganic Cesium-Based Perovskite Solar Cells for Potential Low Earth Orbit Applications
Nigmetova, G., Yelzhanova, Z., Zhumadil, G., Parkhomenko, H. P., Tilegen, M., Zhou, X., Pavlenko, V., Beisenbayev, A., Aidarkhanov, D., Jumabekov, A. N., Kaikanov, M., Pham, T. T., Balanay, M. P., Lim, C. K., Wang, Y., Hu, H. & Ng, A., 2025, (Accepted/In press) In: ACS Applied Materials and Interfaces.Research output: Contribution to journal › Article › peer-review