Ulykbek Kairov, PhD

Head of Laboratory, Lead Researcher

Руководитель лаборатории, Laboratory of bioinformatics and systems biology

Former affiliations

Head of Laboratory - Leading Researcher, Laboratory of bioinformatics and systems biology
Leading Reseacher, Laboratory of bioinformatics and systems biology

Accepting PhD Students

PhD projects

1. Deconvolution of cancer multi-omics profiles (microarrays, RNA-seq, scRNA-seq, methylation) using Independent Component Analysis.
2. Identification and analysis of Kazakh specific genomic variants from whole-genome/exome datasets.
3. Comprehensive transcriptome profiling by NGS and analysis of patients with esophageal cancer from Kazakhstan.

h-index

Research activity per year

40 Article
2 Chapter
1 Conference contribution
1 Case Study
More

47 results

2025
Novel nonsense mutation in gene CHRNA2 identified by whole-genome sequencing in infant with epilepsy disorder: A case report
Makhmetov, S., Temirkhanova, K., Rakhimova, S., Satvaldina, N., Kalendar, R., Kozhamkulov, U., Bolatov, A. K., Bayanova, M., Bazenova, A., Nazarova, L., Akilzhanova, A. & Kairov, U., Jan 20 2025, In: Heliyon. 11, 1, e41484.
Research output: Contribution to journal › Case Study › peer-review

Open Access
File
2024
An Improved Method and Device for Nucleic Acid Isolation Using a High-Salt Gel Electroelution Trap
Kalendar, R., Ivanov, K. I., Akhmetollayev, I., Kairov, U., Samuilova, O., Burster, T. & Zamyatnin, A., Oct 2 2024, In: Analytical Chemistry. 96, 39, p. 15526-15530
Research output: Contribution to journal › Article › peer-review

Open Access
File
3 Citations (Scopus)

6 Downloads (Pure)
Correction to: Whole-Genome Sequencing Among Kazakhstani Children with Early-Onset Epilepsy Revealed New Gene Variants and Phenotypic Variability (Molecular Neurobiology, (2023), 60, 8, (4324-4335), 10.1007/s12035-023-03346-3)
Bayanova, M., Bolatov, A. K., Bazenova, A., Nazarova, L., Nauryzbayeva, A., Tanko, N. M., Rakhimova, S., Satvaldina, N., Samatkyzy, D., Kozhamkulov, U., Kairov, U., Akilzhanova, A. & Sarbassov, D., 2024, (Accepted/In press) In: Molecular Neurobiology.
Research output: Contribution to journal › Comment/debate › peer-review

Open Access
Epidemiological and genetic aspects of pulmonary tuberculosis in Kazakhstan
Yerezhepov, D., Gabdulkayum, A., Akhmetova, A., Abilova, Z., Rakhimova, S., Kairov, U., Akilzhanova, A. & Kozhamkulov, U., Oct 2024, In: Journal of Infection and Public Health. 17, 10, 102540.
Research output: Contribution to journal › Article › peer-review

Open Access
2 Citations (Scopus)
Genome sequence and assembly of the amylolytic Bacillus licheniformis T5 strain isolated from Kazakhstan soil
Mussakhmetov, A., Kiribayeva, A., Daniyarov, A., Bulashev, A., Kairov, U. & Khassenov, B., Dec 2024, In: BMC Genomic Data. 25, 1, 3.
Research output: Contribution to journal › Article › peer-review

Open Access
3 Citations (Scopus)
Genome-Wide Tool for Sensitive de novo Identification and Visualisation of Interspersed and Tandem Repeats
Kalendar, R. & Kairov, U., Jan 1 2024, In: Bioinformatics and Biology Insights. 18
Research output: Contribution to journal › Article › peer-review

Open Access
File
Pulmonary tuberculosis epidemiology and genetics in Kazakhstan
Yerezhepov, D., Gabdulkayum, A., Akhmetova, A., Kozhamkulov, U., Rakhimova, S., Kairov, U., Zhunussova, G., Kalendar, R. & Akilzhanova, A., Apr 19 2024, In: Frontiers in Public Health. 12, 1340673.
Research output: Contribution to journal › Article › peer-review

Open Access
File
1 Citation (Scopus)

24 Downloads (Pure)
Targeted NGS Revealed Pathogenic Mutation in a 13-Year-Old Patient with Homozygous Familial Hypercholesterolemia: A Case Report
Chamoieva, A. E., Mirmanova, Z. Z., Zhalbinova, M. R., Rakhimova, S. E., Daniyarov, A. Z., Kairov, U. Y., Baigalkanova, A. I., Mukarov, M. A., Bekbossynova, M. S. & Akilzhanova, A. R., Nov 2024, In: International journal of molecular sciences. 25, 22, 11882.
Research output: Contribution to journal › Article › peer-review

Open Access
Transcriptome profiling and analysis of patients with esophageal squamous cell carcinoma from Kazakhstan
Sharip, A., Rakhimova, S., Molkenov, A., Ashenova, A., Kozhamkulov, U., Akhmetollayev, I., Zinovyev, A., Zhukov, Y., Omarov, M., Tuleutaev, M., Rakhmetova, V., Terwilliger, J. D., Lee, J. H., Zhumadilov, Z., Akilzhanova, A. & Kairov, U., 2024, In: Frontiers in Genetics. 15, 1249751.
Research output: Contribution to journal › Article › peer-review

Open Access
1 Citation (Scopus)
Vitamin D status, VDR and TLR polymorphisms and pulmonary tuberculosis epidemiology in Kazakhstan
Yerezhepov, D., Gabdulkayum, A., Akhmetova, A., Kozhamkulov, U., Rakhimova, S., Kairov, U., Zhunussova, G., Kalendar, R. & Akilzhanova, A., Feb 17 2024, In: Nutrients. 16, 9, 558.
Research output: Contribution to journal › Article › peer-review

Open Access
File
4 Citations (Scopus)

23 Downloads (Pure)
Whole genome sequencing and de novo genome assembly of the Kazakh native horse Zhabe
Assanbayev, T., Akilzhanov, R., Sharapatov, T., Bektayev, R., Samatkyzy, D., Karabayev, D., Gabdulkayum, A., Daniyarov, A., Rakhimova, S., Kozhamkulov, U., Sarbassov, D., Akilzhanova, A. & Kairov, U., 2024, In: Frontiers in Genetics. 15, 1466382.
Research output: Contribution to journal › Article › peer-review

Open Access
2023
Cardiological Functional Assessment of National Olympic Team of Kazakhstan
Yerezhepov, D., Gabdulkayum, A., Bilyalova, G., Amangeldikyzy, S., Kozhamkulov, U. A., Rakhimova, S. E., Kairov, U. Y. & Akilzhanova, A., Dec 2023, In: Journal of Clinical Medicine. 12, 24, 7511.
Research output: Contribution to journal › Article › peer-review

Open Access
Isolation of high molecular weight DNA for long-read sequencing using a high-salt gel electroelution trap
Kalendar, R., Ivanov, K. I., Samuilova, O., Kairov, U. & Zamyatnin, A., Nov 23 2023, In: Analytical Chemistry. 95, 48, 17818 p.
Research output: Contribution to journal › Article › peer-review

Open Access

6 Citations (Scopus)

4 Downloads (Pure)
Role of Genetic Polymorphisms in the Development of Complications in Patients with Implanted Left Ventricular Assist Devices: HeartWare, HeartMate II, and HeartMate 3
Zhalbinova, M. R., Rakhimova, S. E., Kozhamkulov, U. A., Akilzhanova, G. A., Chinybayeva, A. A., Akilzhanov, K. R., Shaimardanov, N. K., Kuanysheva, A. G., Lee, J. H., Kairov, U. Y., Bekbossynova, M. S. & Akilzhanova, A. R., Dec 2023, In: Journal of Clinical Medicine. 12, 23, 7235.
Research output: Contribution to journal › Article › peer-review

Open Access
2 Citations (Scopus)
Universal whole-genome Oxford nanopore sequencing of SARS-CoV-2 using tiled amplicons
Kalendar, R., Kairov, U., Karabayev, D., Aitkulova, A. M., Tynyshtykbayeva, N., Daniyarov, A., Otarbay, Z., Rakhimova, S., Akilzhanova, A. & Sarbassov, D., Jun 26 2023, In: Scientific Reports. 13, 10334.
Research output: Contribution to journal › Article › peer-review

Open Access
File
1 Citation (Scopus)

73 Downloads (Pure)
Whole-Genome Sequence-Based Characterization of Pre-XDR M. tuberculosis Clinical Isolates Collected in Kazakhstan.
Daniyarov, A., Akhmetova, A., Rakhimova, S., Abilova, Z., Yerezhepov, D., Chingissova, L., Bismilda, V., Takenov, N., Akilzhanova, A., Kairov, U. & Kozhamkulov, U., Jun 8 2023, In: Diagnostics. 13, 12
Research output: Contribution to journal › Article › peer-review
4 Citations (Scopus)
Whole-Genome Sequencing Among Kazakhstani Children with Early-Onset Epilepsy Revealed New Gene Variants and Phenotypic Variability
Bayanova, M., Bolatov, A. K., Bazenova, A., Nazarova, L., Nauryzbayeva, A., Tanko, N. M., Rakhimova, S., Satvaldina, N., Samakyzy, D., Kozhamkulov, U., Kairov, U., Akilzhanova, A. & Sarbassov, D., Apr 24 2023, (E-pub ahead of print) In: Molecular Neurobiology.
Research output: Contribution to journal › Article › peer-review
1 Citation (Scopus)
2022
A high scale SARS-CoV-2 profiling by its whole-genome sequencing using Oxford Nanopore Technology in Kazakhstan
Kairov, U., Amanzhanova, A., Karabayev, D., Rakhimova, S., Aitkulova, A., Samatkyzy, D., Kalendar, R., Kozhamkulov, U., Molkenov, A., Gabdulkayum, A., Sarbassov, D. & Akilzhanova, A., 2022, In: Frontiers in Genetics. 13, p. 906318
Research output: Contribution to journal › Article › peer-review
3 Citations (Scopus)
BIODICA: a computational environment for Independent Component Analysis of omics data
Captier, N., Merlevede, J., Molkenov, A., Seisenova, A., Zhubanchaliyev, A., Nazarov, P. V., Barillot, E., Kairov, U. & Zinovyev, A., Apr 6 2022, (E-pub ahead of print) In: Bioinformatics.
Research output: Contribution to journal › Article › peer-review
5 Citations (Scopus)
Designing Allele-Specific Competitive-Extension PCR-Based Assays for High-Throughput Genotyping and Gene Characterization
Kalendar, R., Shustov, A. V., Akhmetollayev, I. & Kairov, U., Mar 1 2022, In: Frontiers in Molecular Biosciences. 9, 773956.
Research output: Contribution to journal › Article › peer-review

Open Access
18 Citations (Scopus)
Whole-Exome Sequencing Reveals Pathogenic SIRT1 Variant in Brain Arteriovenous Malformation: A Case Report
Mukhtarova, K., Zholdybayeva, E., Kairov, U., Akhmetollayev, I., Nurimanov, C., Kulmirzayev, M., Makhambetov, Y. & Ramankulov, Y., Oct 2022, In: Genes. 13, 10, 1689.
Research output: Contribution to journal › Article › peer-review

Open Access
3 Citations (Scopus)
Whole-Genome Sequencing and Genomic Variant Analysis of Kazakh Individuals
Kairov, U., Molkenov, A., Sharip, A., Rakhimova, S., Seidualy, M., Rhie, A., Kozhamkulov, U., Zhabagin, M., Kim, J-I., Lee, J. H., Terwilliger, J. D., Seo, J-S., Zhumadilov, Z. & Akilzhanova, A., 2022, In: Frontiers in Genetics. 13, p. 902804
Research output: Contribution to journal › Article › peer-review

Open Access
2 Citations (Scopus)
2021
Genomic Analysis of Multidrug-Resistant Mycobacterium tuberculosis Strains From Patients in Kazakhstan
Daniyarov, A., Molkenov, A., Rakhimova, S., Akhmetova, A., Yerezhepov, D., Chingissova, L., Bismilda, V., Toksanbayeva, B., Rakisheva, A., Akilzhanova, A., Kozhamkulov, U. & Kairov, U., Nov 9 2021, In: Frontiers in Genetics. 12, 683515.
Research output: Contribution to journal › Article › peer-review

Open Access
8 Citations (Scopus)
Meta-Analysis of Esophageal Cancer Transcriptomes Using Independent Component Analysis
Seisenova, A., Daniyarov, A., Molkenov, A., Sharip, A., Zinovyev, A. & Kairov, U., Oct 21 2021, In: Frontiers in Genetics. 12, 683632.
Research output: Contribution to journal › Article › peer-review

Open Access
2 Citations (Scopus)
Patients with coronary heart disease, dilated cardiomyopathy and idiopathic ventricular tachycardia share overlapping patterns of pathogenic variation in cardiac risk genes
Guelly, C., Abilova, Z., Nuralinov, O., Panzitt, K., Akhmetova, A., Rakhimova, S., Kozhamkulov, U., Kairov, U., Molkenov, A., Seisenova, A., Trajanoski, S., Abildinova, G., Kaussova, G., Windpassinger, C., Lee, J. H., Zhumadilov, Z., Bekbossynova, M. & Akilzhanova, A., Jan 19 2021, In: PeerJ. 9, e10711.
Research output: Contribution to journal › Article › peer-review

Open Access
6 Citations (Scopus)
Re-Searcher: GUI-based bioinformatics tool for simplified genomics data mining of VCF files
Karabayev, D., Molkenov, A., Yerulanuly, K., Kabimoldayev, I., Daniyarov, A., Sharip, A., Seisenova, A., Zhumadilov, Z. & Kairov, U., May 2021, In: PeerJ. 9, e11333.
Research output: Contribution to journal › Article › peer-review

Open Access
6 Citations (Scopus)
Whole-genome sequencing data of Kazakh individuals
Kairov, U., Molkenov, A., Rakhimova, S., Kozhamkulov, U., Sharip, A., Karabayev, D., Daniyarov, A., H.Lee, J., D.Terwilliger, J., Akilzhanova, A. & Zhumadilov, Z., Dec 2021, In: BMC Research Notes. 14, 1, 45.
Research output: Contribution to journal › Article › peer-review

Open Access
2 Citations (Scopus)
2020
Clinical Utility of Using Next Generation Sequencing in Life Threatening Ventricular Arrhythmia
Akilzhanova, A., Guelly, C., Abilova, Z., Rakhimova, S., Akhmetova, A., Kairov, U., Kozhamkulov, U., Nuralinov, O., Abdrakhmanov, A., Akilzhanova, S., Trajanoski, S., Bekbosynova, M. & Zhumadilov, Z., Apr 2020, In: Journal of Heart and Lung Transplantation. 39, 4S, p. S360
Research output: Contribution to journal › Article › peer-review
Transcriptional Programs Define Intratumoral Heterogeneity of Ewing Sarcoma at Single-Cell Resolution
Aynaud, M-M., Mirabeau, O., Gruel, N., Grossetête, S., Boeva, V., Durand, S., Surdez, D., Saulnier, O., Zaïdi, S., Gribkova, S., Fouché, A., Kairov, U., Raynal, V., Tirode, F., Grünewald, T. G. P., Bohec, M., Baulande, S., Janoueix-Lerosey, I., Vert, J-P., Barillot, E., & 2 othersDelattre, O. & Zinovyev, A., Feb 11 2020, In: Cell Reports. 30, 6, p. 1767-1779.e6
Research output: Contribution to journal › Article › peer-review
92 Citations (Scopus)
Whole genome sequence data of Mycobacterium tuberculosis XDR strain, isolated from patient in Kazakhstan
Daniyarov, A., Molkenov, A., Rakhimova, S., Akhmetova, A., Nurkina, Z., Yerezhepov, D., Chingissova, L., Bismilda, V., Toxanbaeva, B., Akilzhanova, A., Kozhamkulov, U. & Kairov, U., Dec 2020, In: Data in Brief. 33, 106416.
Research output: Contribution to journal › Article › peer-review

Open Access
5 Citations (Scopus)
2019
Assessing reproducibility of matrix factorization methods in independent transcriptomes
Cantini, L., Kairov, U., De Reyniès, A., Barillot, E., Radvanyi, F. & Zinovyev, A., Nov 1 2019, In: Bioinformatics. 35, 21, p. 4307-4313 7 p.
Research output: Contribution to journal › Article › peer-review

Open Access
16 Citations (Scopus)
Independent Component Analysis for Unraveling the Complexity of Cancer Omics Datasets
Sompairac, N., Nazarov, P. V., Czerwinska, U., Cantini, L., Biton, A., Molkenov, A., Zhumadilov, Z., Barillot, E., Radvanyi, F., Gorban, A., Kairov, U. & Zinovyev, A., Sept 7 2019, In: International Journal of Molecular Sciences. 20, 18, 4414.
Research output: Contribution to journal › Review article › peer-review

Open Access
58 Citations (Scopus)
2018
Application of independent component analysis to tumor transcriptomes reveals specific and reproducible immune-related signals
Czerwinska, U., Cantini, L., Kairov, U., Barillot, E. & Zinovyev, A., Jan 1 2018, Latent Variable Analysis and Signal Separation - 14th International Conference, LVA/ICA 2018, Proceedings. Gannot, S., Deville, Y., Mason, R., Plumbley, M. D. & Ward, D. (eds.). Springer Verlag, p. 501-513 13 p. (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); vol. 10891 LNCS).
Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
3 Citations (Scopus)
Genetic Epidemiologyof Ventricular Tachycardia in Patients with Cardiomyopathy in Kazakhstan: ATargeted Sequencing Study
Bekbossynova, M., Akilzhanova, A., Guelly, C., Abilova, Z., Akhmetova, A., Kairov, U., Nuralinov, O., Rashbayeva, G., Trajanoski, S., Abdirova, B. & Zhumadilov, Z., Apr 1 2018, In: Journal of Heart and Lung Transplantation. 37, 4, p. S322
Research output: Contribution to journal › Article › peer-review
Stabilized Independent Component Analysis outperforms other methods in finding reproducible signals in tumoral transcriptomes
Kairov, U., 2018, In: bioRxiv.
Research output: Contribution to journal › Article
Transcriptomic databases
Molkenov, A., Zhelambayeva, A., Yermekov, A., Mussurova, S., Sarkytbayeva, A., Kalykhbergenov, Y., Zhumadilov, Z. & Kairov, U., Jan 1 2018, Encyclopedia of Bioinformatics and Computational Biology: ABC of Bioinformatics. Elsevier B.V., Vol. 1-3. p. 341-351 11 p.
Research output: Chapter in Book/Report/Conference proceeding › Chapter
2 Citations (Scopus)
Transcriptomic Databases
Kairov, U., Jun 2018, Encyclopedia of Bioinformatics and Computational Biology. p. 341-351 11 p. (Encyclopedia of Bioinformatics and Computational Biology).
Research output: Chapter in Book/Report/Conference proceeding › Chapter
2017
Apoptotic and genotoxic effects of low-intensity ultrasound on healthy and leukemic human peripheral mononuclear blood cells
Saliev, T., Begimbetova, D., Baiskhanova, D., Abetov, D., Kairov, U., Gilman, C. P., Matkarimov, B. & Tachibana, K., Jul 8 2017, (E-pub ahead of print) In: Journal of medical ultrasonics (2001).
Research output: Contribution to journal › Article › peer-review
6 Citations (Scopus)
Determining the optimal number of independent components for reproducible transcriptomic data analysis
Kairov, U., Cantini, L., Greco, A., Molkenov, A., Czerwinska, U., Barillot, E. & Zinovyev, A., Sept 11 2017, In: BMC Genomics. 18, 1, p. 712
Research output: Contribution to journal › Article › peer-review
43 Citations (Scopus)
2015
Draft genome sequence of Lactobacillus rhamnosus CLS17
Kozhakhmetov, S. S., Kushugulova, A. R., Saduakhasova, S. A., Shakhabayeva, G. S., Khassenbekova, Z. R., Molkenov, A. B., Kairov, U. E., Issayeva, R. B., Nurgozhin, T. S. & Zhumadilov, Z. S., 2015, In: Genome Announcements. 3, 3, e00478-15.
Research output: Contribution to journal › Article › peer-review
Draft genome sequences of two clinical isolates of Mycobacterium tuberculosis from sputum of Kazakh patients
Kairov, U., Kozhamkulov, U., Molkenov, A., Rakhimova, S., Askapuli, A., Zhabagin, M., Akhmetova, A., Yerezhepov, D., Abilova, Z., Abilmazhinova, A., Bismilda, V., Chingisova, L., Zhumadilov, Z. & Akilzhanova, A., 2015, In: Genome Announcements. 3, 3, e00466-15.
Research output: Contribution to journal › Article › peer-review
5 Citations (Scopus)
2014
Cancer-related genes in the transcription signature of facioscapulohumeral dystrophy myoblasts and myotubes
Dmitriev, P., Kairov, U., Robert, T., Barat, A., Lazar, V., Carnac, G., Laoudj-Chenivesse, D. & Vassetzky, Y. S., Feb 2014, In: Journal of Cellular and Molecular Medicine. 18, 2, p. 208-217 10 p.
Research output: Contribution to journal › Article › peer-review

Open Access
9 Citations (Scopus)
Genetic Diversity of IFγ, IL1β, TLR2, and TLR8 Loci in Pulmonary Tuberculosis in Kazakhstan
Yerezhepov, D., Zhabagin, A., Askapuli, A., Rakhimova, S., Nurkina, Z., Abilmazhinova, A., Akhmetova, A., Molkenov, A., Kairov, U. & Akilzhanova, A., 2014, In: Central Asian journal of global health. 3, Suppl, p. 181
Research output: Contribution to journal › Article › peer-review
The First Kazakh Whole Genomes: The First Report of NGS Data
Akilzhanova, A., Kairov, U., Rakhimova, S., Molkenov, A., Rhie, A., Kim, J-I., Seo, J-S. & Zhumadilov, Z., 2014, In: Central Asian journal of global health. 3, Suppl, p. 146
Research output: Contribution to journal › Article
2013
Blind source separation methods for deconvolution of complex signals in cancer biology
Zinovyev, A., Kairov, U., Karpenyuk, T. & Ramanculov, E., Jan 18 2013, In: Biochemical and Biophysical Research Communications. 430, 3, p. 1182-1187 6 p.
Research output: Contribution to journal › Short survey › peer-review
24 Citations (Scopus)
Vitamin D Receptor Gene Polymorphisms in Susceptibility to Tuberculosis in the Kazakh Population in Almaty and Almaty Area
Zhabagin, M., Abilova, Z., Askapuli, A., Rakhimova, S., Kairov, U., Berikkhanova, K., Terlikbayeva, A., Darisheva, M., Alenova, A. & Akilzhanova, A., 2013, In: Central Asian journal of global health. 2, Suppl, p. 102
Research output: Contribution to journal › Article › peer-review
2012
Network analysis of gene lists for finding reproducible prognostic breast cancer gene signatures
Kairov, U., Karpenyuk, T., Ramanculov, E. & Zinovyev, A., 2012, In: Bioinformation. 8, 16, p. 773-6 4 p.
Research output: Contribution to journal › Article › peer-review

Ulykbek Kairov, PhD

Research output

Search results