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Professional Information
Dr. Xie received the Ph.D. in Genetics from Institute of Genetics and Developmental Biology, Chinese Academy of Sciences. During Ph.D. studies, Dr. Xie discovered a strong promoter for bioengineering from viral genome which was awarded a USA patent. During his postdoctoral training, Dr. Xie discovered novel diagnostic and prognostic markers of prostate cancer such as PIM-1L and nMET. Dr. Xie also found mechanisms of multiple drug resistance, novel signaling networks in prostate, breast cancer and leukemia. Dr. Xie has supervised students to carry out cancer research and to publish their research results since he joined the Nazarbayev University as an Assistant Professor. Dr. Xie’s current research is focusing on molecular and biochemical mechanisms of cancer and other diseases and precision therapeutics.
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Collaborations and top research areas from the last five years
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Targeting ACE 2 in hepatocellular carcinoma carbon nanodots conjugated with saffton-derived crocin
Xie, Y. (PI) & Amin, A. (Co-PI)
10/14/22 → 10/14/24
Project: International
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Improving the efficacy of PARP inhibition with Sulfur-Carbon Nanodots through DNA damage response
Xie, Y. (PI) & Dukenbayev, K. (Other Faculty/Researcher)
1/1/22 → 12/31/24
Project: FDCRGP
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Prostate cancer drug target: Targeting cancer stem-like cells of castration-resistant prostate cancer through combinatorial inhibition of MET/nuclear MET and β-Catenin pathways: potential therapeutic intellectual property in prostate cancer treatment
Xie, Y. (PI), Fan, H. (Co-PI), Dukenbayev, K. (Co-PI) & Chen, Z. (Other Faculty/Researcher)
1/31/19 → 8/31/22
Project: FDCRGP
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Phosphatase-like nanozyme activity of carbon nanodots and its potential as supplement for kinase inhibitor drug treating prostate cancer: potential intellectual property discovered in food product
Fan, H. (PI), Xie, Y. (Co-PI) & Chen, Z. (Co-PI)
1/31/19 → 5/31/22
Project: FDCRGP
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Antibiotic-Modified Nanoparticles Combined with Lysozyme for Rapid Extraction of Pathogenic Bacteria DNA in Blood
Li, Y., Qi, Y., Liu, J., Wang, P., Zheng, J., Chen, X., Wang, Y., Zhao, X., Xie, Y., Shi, C. & Ma, C., 2025, (Accepted/In press) In: Analytical Chemistry.Research output: Contribution to journal › Article › peer-review
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Antibiotic-Modified Nanoparticles Combined with Lysozyme for Rapid Extraction of Pathogenic Bacteria DNA in Blood
Li, Y., Qi, Y., Liu, J., Wang, P., Zheng, J., Chen, X., Wang, Y., Zhao, X., Xie, Y., Shi, C. & Ma, C., Mar 25 2025, In: Analytical Chemistry. 97, 11, p. 6201-6210 10 p.Research output: Contribution to journal › Article › peer-review
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Light controllable smart Poly(ADP-ribose) polymerase-1 inhibitor delivery by sustainable green materials for regulation of cytotoxicity
Nazarbek, G., Omarova, Z., Shaimoldina, A., Bauyrzhanova, Z., Kondratyeva, M., Zeitkaziyeva, D., Onggarbek, A., Orassay, A., Fan, H., Toktarov, N., Amin, A. & Xie, Y., Aug 2025, In: Journal of Drug Delivery Science and Technology. 110, 107036.Research output: Contribution to journal › Article › peer-review
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Microevolution and phylogenomic study of Respiratory Syncytial Virus type A
Ahmad, A., Majaz, S., Saeed, A., Noreen, S., Abbas, M., Khan, B., Rahman, H. U., Nouroz, F., Xie, Y., Rashid, A. & Rehman, A. U., Feb 2025, In: PLoS ONE. 20, 2 February, e0319437.Research output: Contribution to journal › Article › peer-review
Open Access -
Microneedle-Enabled Breakthroughs in Nucleic Acid Therapeutics
Wu, P., Zhang, T., Zhao, D., Xie, Y., Huang, D., Li, Z. & Huang, Y., 2025, (Accepted/In press) In: Advanced Healthcare Materials.Research output: Contribution to journal › Review article › peer-review
1 Citation (Scopus)