Projects per year
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Professional Information
Dr. Xie received the Ph.D. in Genetics from Institute of Genetics and Developmental Biology, Chinese Academy of Sciences. During Ph.D. studies, Dr. Xie discovered a strong promoter for bioengineering from viral genome which was awarded a USA patent. During his postdoctoral training, Dr. Xie discovered novel diagnostic and prognostic markers of prostate cancer such as PIM-1L and nMET. Dr. Xie also found mechanisms of multiple drug resistance, novel signaling networks in prostate, breast cancer and leukemia. Dr. Xie has supervised students to carry out cancer research and to publish their research results since he joined the Nazarbayev University as an Assistant Professor. Dr. Xie’s current research is focusing on molecular and biochemical mechanisms of cancer and other diseases and precision therapeutics.
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Collaborations and top research areas from the last five years
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Improving the efficacy of PARP inhibition with Sulfur-Carbon Nanodots through DNA damage response
Xie, Y. & Dukenbayev, K.
1/1/22 → 12/31/24
Project: FDCRGP
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Prostate cancer drug target: Targeting cancer stem-like cells of castration-resistant prostate cancer through combinatorial inhibition of MET/nuclear MET and β-Catenin pathways: potential therapeutic intellectual property in prostate cancer treatment
Xie, Y., Fan, H., Dukenbayev, K. & Chen, Z.
1/31/19 → 8/31/22
Project: FDCRGP
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Carbon nanoparticle-induced cell death
Myrzagali, S., Omarova, Z., Zeitkaziyeva, D., Madet, A. & Xie, Y., Jun 2024, In: Carbon Trends. 15, 100352.Research output: Contribution to journal › Review article › peer-review
Open Access1 Citation (Scopus) -
Carbon nanoparticles neutralize carbon dioxide (CO2) in cytotoxicity: Potent carbon emission induced resistance to anticancer nanomedicine and antibiotics
Shaimoldina, A., Sergazina, A., Myrzagali, S., Nazarbek, G., Omarova, Z., Mirza, O., Fan, H., Amin, A., Zhou, W. & Xie, Y., Mar 15 2024, In: Ecotoxicology and Environmental Safety. 273, 116024.Research output: Contribution to journal › Article › peer-review
Open Access1 Citation (Scopus) -
Deer antler extract: Pharmacology, rehabilitation and sports medicine applications
Orassay, A., Sadvokassova, D., Berdigaliyev, A., Sagintayev, A., Myrzagali, S., Omarova, Z., Toktarov, N., Liu, D. & Xie, Y., Mar 2024, In: Pharmacological Research - Modern Chinese Medicine. 10, 100316.Research output: Contribution to journal › Review article › peer-review
Open Access3 Citations (Scopus) -
Deer antler extract-nanoparticles exhibit co-nanozyme activity and targeting of prostate cancer cells
Nazarbek, G., Mu, C., Shaimoldina, A., Omarova, Z., Toktarov, N., Wang, L. X., Ahmad, A., Zeitkaziyeva, D., Fan, H., Shi, L., Chen, Z. & Xie, Y., Apr 2024, In: Journal of Functional Foods. 115, 106089.Research output: Contribution to journal › Article › peer-review
Open Access -
Highly sensitive detection of RNase H via a novel DNA/RNA heteroduplex combining isothermal exponential amplification strategy
Zhang, X., Jia, Q., Shi, Y., Gao, Z., Amin, A., Xie, Y. & Li, Y., Dec 2024, In: Microchemical Journal. 207, 111756.Research output: Contribution to journal › Article › peer-review