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Professional Information
Dr. Xie received the Ph.D. in Genetics from Institute of Genetics and Developmental Biology, Chinese Academy of Sciences. During Ph.D. studies, Dr. Xie discovered a strong promoter for bioengineering from viral genome which was awarded a USA patent. During his postdoctoral training, Dr. Xie discovered novel diagnostic and prognostic markers of prostate cancer such as PIM-1L and nMET. Dr. Xie also found mechanisms of multiple drug resistance, novel signaling networks in prostate, breast cancer and leukemia. Dr. Xie has supervised students to carry out cancer research and to publish their research results since he joined the Nazarbayev University as an Assistant Professor. Dr. Xie’s current research is focusing on molecular and biochemical mechanisms of cancer and other diseases and precision therapeutics.
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Collaborations and top research areas from the last five years
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Targeting ACE 2 in hepatocellular carcinoma carbon nanodots conjugated with saffton-derived crocin
Xie, Y. (PI) & Amin, A. (Co-PI)
10/14/22 → 10/14/24
Project: International
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Improving the efficacy of PARP inhibition with Sulfur-Carbon Nanodots through DNA damage response
Xie, Y. (PI) & Dukenbayev, K. (Other Faculty/Researcher)
1/1/22 → 12/31/24
Project: FDCRGP
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Phosphatase-like nanozyme activity of carbon nanodots and its potential as supplement for kinase inhibitor drug treating prostate cancer: potential intellectual property discovered in food product
Fan, H. (PI), Xie, Y. (Co-PI) & Chen, Z. (Co-PI)
1/31/19 → 5/31/22
Project: FDCRGP
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Aicao (Artemisia argyi)/Honey processing by different temperatures generates particles with enhanced targeting of AKT kinase and ferroptosis for pharmaceuticals as a non-food industrial use
Tassanbiyeva, A., Li, M., Onggarbek, A., Gemingbai, S., Lei, L., Toktau, G., Song, H., Wang, H., Toktarov, N., Tong, F., Liu, X., Meng, L., Qi, R., Liu, D., Sun, H. & Xie, Y., Jul 2026, In: Industrial Crops and Products. 249, 123459.Research output: Contribution to journal › Article › peer-review
Open Access -
Combating VEGFA-siRNA-Induced Metabolic Reprogramming via Glucose Utilization Deprivation
Zheng, L., Guo, S., Luo, Y., Wu, P., Yang, H., Xie, Y., Fan, Y., Liu, Q., Hu, B., Huang, J. & Huang, Y., 2026, (Accepted/In press) In: Advanced Science.Research output: Contribution to journal › Article › peer-review
Open Access -
Context-dependent rewiring of the cGAS-STING pathway in cancer: Implications for immunotherapy and therapeutic resistance
Majaz, S., Ahmad, A., Liu, D., Ud-din, A., khan, I., Cui, Y. & Xie, Y., Aug 2026, In: Critical Reviews in Oncology/Hematology. 224, 105368.Research output: Contribution to journal › Article › peer-review
1 Link opens in a new tab Citation (Scopus) -
Cycloastragalol nanoparticle-loaded composite hydrogel as an injectable embolic agent for vascular repair in a mouse model of abdominal aortic aneurysm
Song, T., Huang, X., Xu, J., Wang, Y., Lin, J., Hu, W., Zhang, T., Li, Q., Di, C., Khaitbaev, A., Xie, Y., Chiu, J. J., Hsu, S. H. & Qi, R., Dec 2026, In: Journal of Nanobiotechnology. 24, 1, 667.Research output: Contribution to journal › Article › peer-review
Open Access -
Mitochondrial Enzymes Mimetic Ultrasmall Palladium Nanozymes Prevent Senescence and Neurodegeneration Through Metabolic Reprogramming
Cong, W., Jing, H., Li, Z., Zhang, W., Zhang, N., Xie, Y., Gao, S., Huang, Y. & Ning, J., 2026, (Accepted/In press) In: Advanced Science.Research output: Contribution to journal › Article › peer-review
Open Access