Autoimmune mechanisms of Brucellosis-induced Spondyloarthritis

Project: Research project

Grant Program

ORAU Grant

Project Description

The project investigated the relationship between a specific peptide sequence, the Brucella-derived CTL epitope LRYCINSASL, found highly conserved in the bacterial and human methionine sulfoxide reductase B3 (MSRB3) protein, and the possible relationship to the development of spondyloarthropathy in the patient population that experienced Brucella infections. Spondyloarthropathies (SpA) comprise a group of chronic inflammatory diseases that share several clinical features and are genetically linked to MHC class I alleles, mainly of the HLA B27 type. The proposed experiments were designed to dissect out the underlying mechanisms of the development of spondyloarthropathy by examining how human patients exposed to Brucella may have been sensitized to particular epitopes that were shared between Brucella and human proteins.
Effective start/end date10/1/1512/31/17