Building a uniform platform for streamlining the development of new methodologies towards high added value chemicals: a step forward from multicomponent reactions

Project: FDCRGP

Project Details

Grant Program

Faculty Development Competitive Research Grants Program 2022-2024

Project Description

Kazakhstan possesses around 3% of total global oil reserves placing it among the world’s top 15 countries in terms of proven oil reserves [1]. Meanwhile, over 70% of extracted oil gets exported mostly in a crude form [2] while local refinery and chemical industries remain underdeveloped for decades [3]. Furthermore, basic research in the field of synthetic methodology is almost nonexistent in Kazakhstan despite that it can boost the development of chemical and pharmaceutical industries as well as help with creating demand on a local supply market. Chemistry is frequently referred to as a “central science” for its key role in advancing technological progress and human wellbeing through the design and synthesis of novel molecules and materials for a variety of applications. In the future, humankind will face many new challenges in science and biomedicine that will require extensive discovery of novel chemical entities as well as efficient synthetic methodologies to access them. Multicomponent reactions (MCRs) are convergent chemical transformations allowing the construction of complex molecular architectures by simultaneous incorporation of three or more relatively simple building blocks by taking advantage of their complementary reactivity. MCRs allow an easy variation of starting materials and thus their application can intensify the design and discovery of new molecules and materials with required properties. In line with that, MCRs are heavily exploited in organic and medicinal chemistry fueling the concept of Diversity-Oriented Synthesis (DOS) through the construction of libraries of potentially bioactive molecules in step and atom economic manner. Accordingly, MCR-based strategies can be readily tuned towards the generation of a wide range of heterocyclic scaffolds, both privileged and less explored ones, either directly or in conjunction with appropriate post-transformations [4]. While at first glance it may appear that a lot of work has already been done in this area, the proposed research may extend the frontiers of multicomponent chemistry by showcasing how a number of fundamental and practical aspects can be uncovered using a unified approach based on one particular structural feature.
StatusActive
Effective start/end date1/1/2212/31/24

Keywords

  • Multicomponent reactions
  • Ugi reaction
  • Assymetric synthesis
  • Diversity-oriented synthesis
  • beta-lactams
  • Aggregation-induced emission
  • Polymer chemistry
  • Sequence-defined oligomers

Fingerprint

Explore the research topics touched on by this project. These labels are generated based on the underlying awards/grants. Together they form a unique fingerprint.