Defining a redox-dependent pre-apoptotic nuclear condensation in KRAS mutant cancer cells

Project: FDCRGP

Project Details

Grant Program

Faculty-development competitive research grants program for 2023-2025

Project Description

Nuclear condensation is a hallmark of apoptotic cell death. Chromatin packing precedes nuclear condensation. The mechanism of a redox-dependent nuclear condensation is a main focus of the proposal.
Short titleNuclear Condensation
Effective start/end date1/1/2312/31/25


  • apoptosis
  • nuclear condensation
  • reactive oxygen species (ROS)
  • histone deacetylation
  • heterochromatin
  • KRAS mutant cancer cells
  • thiol-reactive groups
  • chromatin


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