Improving the efficacy of PARP inhibition with Sulfur-Carbon Nanodots through DNA damage response

  • Xie, yingqiu (PI)
  • Dukenbayev, Kanat (Other Faculty/Researcher)

Project: FDCRGP

Project Details

Grant Program

Faculty Development Competitive Research Grants Program 2022-2024

Project Description

This study will elucidate the concise mechanism of Sulfur-doped carbon Nanodots conjugated PARP inhibitor mediated DNA damage in genomic instability and gene expression and provide new ideas for cancer treatment. The proposal may provide the conceptual innovations that applying Sulfur-doped carbon Nanodots as novel “ green” drug delivery nanomaterials to increase efficiency of PARP inhibitor to prevent DNA repair thereby enhancing therapy efficacy, and overcoming drug resistance.
Short titlePARP inhibitor delivery targeting DNA damage
StatusFinished
Effective start/end date1/1/22 → 12/31/24

Keywords

  • DNA damage
  • DNA repair
  • drug resistance
  • carbon nanodots
  • Prostate cancer

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