Investigating endoplasmic reticulum oxidoreductase 1 alpha and protein disulfide isomerase interface as a potential target for anticancer therapy

  • Aljofan, Mohamad (PI)
  • Gulyayev, Alexandr (Co-PI)
  • Nurkenov , Oral A (Co-PI)
  • Koes, David (Co-PI)
  • Saktashev, Bolat (Other Faculty/Researcher)
  • Poon , Ivan (Other Faculty/Researcher)

Project: CRP

Project Details

Grant Program

Collaborative Research Program for 2025-2027

Project Description

The interface between Ero1α with PDIA1 might provide a potential drug target for cancer treatment. Thus, small molecules selectively targeting ERO1α and PDIA1 interface will likely
result in hits capable of reducing cellular proliferation, and possibly providing suitable candidates for further development as potential anticancer therapeutics.
StatusActive
Effective start/end date1/1/25 → 12/31/27

Keywords

  • ERO1α
  • Protein disulfide isomerase
  • Virtual drug screen
  • Anticancer
  • Drug Screening
  • Drug target

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