Long non-coding RNA and microRNA identification in esophageal squamous cell carcinoma

Project: CRP

Project Details

Grant Program

Collaborative Research Program 2021-2023

Project Description

Esophageal cancer is one of the 10 most common and deadly malignant tumors in the world [1]. About 14 090 149 new cases are diagnosed annually. In Kazakhstan, there is a high incidence of esophageal cancer, the incidence rate is 10.1: 100 000. In the cancer mortality rate in Kazakhstan, esophageal cancer among men occupies the 5th place, among women - the ninth place. Esophageal cancer is represented by two main forms - esophageal squamous cell carcinoma (ESCC) and adenocarcinoma,and ESCC is the predominant type [2]. While in the countries of Europe and America, esophageal adenocarcinoma is more common [3,4]. There is a tendency to form high risk groups in certain geographic areas, which may indicate a genetic component in these populations. This refers to the countries forming the so-called "Asian cancer belt", which includes the southern coast of the Caspian Sea in the west to North China in the east and the countries: Iran, Afghanistan, Mongolia, Central Asia and the Siberian part of Russia. Despite the prevalence of squamous cell carcinoma of the esophagus, in contrast to adenocarcinoma of the esophagus is not sufficiently studied.
Short titlelncRNA and microRNA identification in ESCC
StatusActive
Effective start/end date1/1/216/30/24

Keywords

  • esophagus
  • sequencing
  • carcinogenesis