Research output per year
Research output per year
Project Details
Grant Program
Collaborative Research Grants Program 2020-2022
Project Description
The aim of this project is to establish the chemical identity and physiological function of two novel post-translational modifications of DJ-1, a protein implicated in the early onset of Parkinson's disease. Post-translational modifications will be studied by combination of mass-spectrometry, protein X-ray crystallography and various biochemical assays. The project holds the potential to discover the molecular function of DJ-1 and directly link it to the etiology of Parkinson's disease, suggesting possible novel therapeutic interventions for the disease.
| Status | Active |
|---|---|
| Effective start/end date | 1/1/20 → 12/31/24 |
Keywords
- Neurodegeneration
- DJ-1
- Oxidative stress
- Post-translational modifications
- X-ray crystallography
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Research output
- 1 Article
-
DJ-1 protects proteins from acylation by catalyzing the hydrolysis of highly reactive cyclic 3-phosphoglyceric anhydride
Akhmadi, A., Yeskendir, A., Dey, N., Mussakhmetov, A., Shatkenova, Z., Kulyyassov, A., Andreeva, A. & Utepbergenov, D., Dec 2024, In: Nature Communications. 15, 1, 2004.Research output: Contribution to journal › Article › peer-review
Open Access2 Citations (Scopus)