Non-Mendelian genetics: Regulation of imprinted genes by HP1 proteins

Project: Research project

Grant Program

Faculty Development Competitive Research Grant Program 2018-2020

Project Description

Our purpose is to elucidate, in concrete molecular and cellular terms, the role of mammalian HP1 proteins in parent-of-origin effects in mammals. We have three objectives, which are:
(i) Determine the changes in DNA methylation at imprinted gDMRs in HP1-null TKO ES cells [0-12 months].
(ii) Determine the histone modification changes at imprinted gDMRs in HP1-null TKO ES cells [12-24 months].
(iii) Determine the changes in transcriptional regulation of imprinted genes in HP1-null TKO ES cells [24-36 months]
StatusActive
Effective start/end date3/20/1812/31/20

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Histone Code
Proteins
DNA Methylation
Mammals
Genes