Research output per year
Research output per year
Project Details
Grant Program
Faculty Development Competitive Research Grant Program 2018-2020
Project Description
Our purpose is to elucidate, in concrete molecular and cellular terms, the role of mammalian HP1 proteins in parent-of-origin effects in mammals. We have three objectives, which are:
(i) Determine the changes in DNA methylation at imprinted gDMRs in HP1-null TKO ES cells [0-12 months].
(ii) Determine the histone modification changes at imprinted gDMRs in HP1-null TKO ES cells [12-24 months].
(iii) Determine the changes in transcriptional regulation of imprinted genes in HP1-null TKO ES cells [24-36 months]
(i) Determine the changes in DNA methylation at imprinted gDMRs in HP1-null TKO ES cells [0-12 months].
(ii) Determine the histone modification changes at imprinted gDMRs in HP1-null TKO ES cells [12-24 months].
(iii) Determine the changes in transcriptional regulation of imprinted genes in HP1-null TKO ES cells [24-36 months]
| Status | Finished |
|---|---|
| Effective start/end date | 1/1/18 → 6/1/21 |
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Research output
- 5 Review article
-
On the relations of phase separation and Hi-C maps to epigenetics
Singh, P. B. & Newman, A. G., Feb 1 2020, In: Royal Society Open Science. 7, 2, 191976.Research output: Contribution to journal › Review article › peer-review
Open Access16 Citations (Scopus) -
Deconstructing age reprogramming
Singh, P. B., Laktionov, P. P. & Newman, A. G., Sept 1 2019, In: Journal of Biosciences. 44, 4, 106.Research output: Contribution to journal › Review article › peer-review
6 Citations (Scopus) -
Maternal regulation of chromosomal imprinting in animals
Singh, P. B., Shloma, V. V. & Belyakin, S. N., Jun 4 2019, In: Chromosoma. 128, 2, p. 69-80 12 p.Research output: Contribution to journal › Review article › peer-review
Open Access9 Citations (Scopus)