This proposal aims to solve a critical public health problem important for Kazakhstan’s population – patient fatality from breast cancer - through the study of underlying disease mechanisms using in vivo models of cancer and the development of new therapeutic interventions. Breast cancer is the most commonly diagnosed form of cancer in women 35-55 years of age worldwide and is also a significant and increasing health problem in Kazakhstan. Metastatic breast cancer, where tumor cells break away from the original tumor to form distant metastases, is the primary cause of patient death. Despite the obvious importance of metastasis, therapeutic strategies that specifically target this process remain to be developed. A hallmark of metastasis is that cancer cells “hijack” the machinery that normal cells use to migrate. The proposed research aims at targeting the molecular switches that drive cell migration in normal cells and that are subverted in pathological situations. Specifically the proposed research aims to develop pharmacological strategies to target the signaling processes regulated by the lipid phosphatidylinositol-4,5-bisphosphate (PIP2). We focus on PIP2, because PIP2 is central to the control of multiple distinct signaling networks critical for cell migration.
|Effective start/end date||1/10/16 → 3/31/21|
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