Studying activity of peripheral blood monocytes and adiponectin receptors expression in association with plasma adiponectin in patients with Alzheimer’s disease

Project: Research project

Grant Program

Collaborative Research Grants Program 2020-2022

Project Description

In the past ten years considerable information has been accumulated on the importance of adiponectin activity (APN) in the pathogenesis of Alzheimer’s disease (AD). However, the published data are controversial, and the role of adiponectin in the etiology of AD is not fully understood. Therefore, more studies are needed to reveal an association between plasma adiponectin level
and AD. Further insights into the various mechanisms through which APN is involved in AD pathology may contribute to deeper understanding of AD pathogenesis and provide clues for development of novel biomarkers and treatment strategies. The overall goal of the proposed research is studying expression of adiponectin receptors AdipoR1 and AdipoR2 on the surface of peripheral blood monocytes, their M1/M2 polarization phenotypes, anti-inflammatory response and phagocytic activity in association with plasma
adiponectin levels in patients with Alzheimer’s disease (AD) in comparison with age- and sex- matched healthy individuals.
Specific aims:
1. Study of AdipoR1 and AdipoR2 expression levels on the surface of peripheral blood monocytes collected from the patients with AD and age- and sex- matched healthy individuals in association with plasma adiponectin levels.
2. Study of the M1/M2 polarization phenotypes of blood monocytes collected from the patients with AD and age- and sex- matched healthy individuals in association with plasma adiponectin levels.
3. Study of pro-inflammatory and anti-inflammatory cytokine release by activated blood monocytes collected from the patients with AD and age- and sex- matched healthy individuals in association with plasma adiponectin levels.
4. Study the effects of adiponectin treatment on phagocytic activity of Аβ42 in peripheral blood monocytes collected from the patients with AD and age- and sex- matched healthy individuals.
The long-range goal of the proposed research is to provide novel information on some mechanisms through which adiponectin and peripheral blood monocytes could be involved in AD. These finding will contribute to deeper understanding of AD pathogenesis and may serve as a basis for the development of prognostic biomarkers of Alzheimer's disease.
StatusActive
Effective start/end date1/1/2012/31/22

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Adiponectin Receptors
Adiponectin
Monocytes
Alzheimer Disease
Anti-Inflammatory Agents
Biomarkers
Research
Phenotype
Organized Financing

Keywords

  • Alzheimers disease
  • Adiponectin
  • Monocytes