Suppression of SARS-CoV-2 viral replication and assembly by lithium chloride aerosol: Rationale for treatment of COVID-19 patients

Project: Monitored by Research Administration

Project Details

Grant Program

Faculty-development competitive research grants program for 2021-2023

Project Description

Glycogen synthase kinase 3 (GSK3) plays a critical role in viral assembly and replication of SARS-CoV suggesting that inhibition of GSK3 kinase activity by lithium chloride (LiCl) will inhibit a propagation of SARS-CoV-2. To determine the efficacy of LiCl, we propose to carry out a randomized clinical trial studies (Phase I- safety) and (Phase II-efficacy) to determine how effective an inhalation of LiCl in treatment of COVID-19 patients.
Short titleLithium Chloride aerosol to treat COVID-19
StatusActive
Effective start/end date1/1/2112/31/23

Keywords

  • COVID-19, SARS-CoV-2
  • Lithium Chloride
  • Virus replication and assembly
  • clinical trial studies Phase I and Phase II
  • aerosol, inhalation
  • glycogen synthase 3

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