Targeting cancer stem-like cells of castration-resistant prostate cancer through combinatorial inhibition of MET/nuclear MET and β-Catenin pathways: potential therapeutic intellectual property in prostate cancer treatment

Xie, yingqiu (PI)
Fan, Haiyan (Co-PI)
Dukenbayev, Kanat (Co-PI)
Chen, Zhenbang (Other Faculty/Researcher)

Project: FDCRGP

Grant Program

Faculty Development Competitive Research Grant Program 2019-2021

Project Description

Our goal is to determine whether the Crizotinib and iCRT3 combination enhances the anti-cancer effects of either Crizotinib or iCRT3 alone in human CRPC cells by targeting cancer stem-like cells and to define the mechanism by which combinatorial drugs inhibited nuclear MET/β-Catenin/ AR and novel signaling in human CRPC cells.

Short title	Targeting prostate cancer stem cell
Acronym	Prostate cancer drug target
Status	Finished
Effective start/end date	1/31/19 → 8/31/22

Keywords

Prostate cancer
Experimental therapy

4 Article
1 Editorial

Carbon nanoparticles induce DNA repair and PARP inhibitor resistance associated with nanozyme activity in cancer cells
Fan, H., Sun, Q., Dukenbayev, K., Benassi, E., Manarbek, L., Nurkesh, A. A., Khamijan, M., Mu, C., Li, G., Razbekova, M., Chen, Z., Amin, A. & Xie, Y., Dec 2022, In: Cancer Nanotechnology. 13, 1, 39.
Research output: Contribution to journal › Article › peer-review

Open Access
8 Citations (Scopus)
Editorial: Molecular mechanisms of epithelial-mesenchymal transition in cancer metastasis
Amin, A., Alyahyaee, M., Xie, Y. & Tahtamouni, L., Dec 6 2022, In: Frontiers in Oncology. 12, 1088205.
Research output: Contribution to journal › Editorial › peer-review

Open Access

4 Citations (Scopus)
Generation of particle assemblies mimicking enzymatic activity by processing of herbal food: The case of rhizoma polygonati and other natural ingredients in traditional Chinese medicine
Benassi, E., Fan, H., Sun, Q., Dukenbayev, K., Wang, Q., Shaimoldina, A., Tassanbiyeva, A., Nurtay, L., Nurkesh, A., Kutzhanova, A., Mu, C., Dautov, A., Razbekova, M., Kabylda, A., Yang, Q., Li, Z., Amin, A., Li, X. & Xie, Y., Apr 21 2021, In: Nanoscale Advances. 3, 8, p. 2222-2235 14 p.
Research output: Contribution to journal › Article › peer-review

Open Access
34 Citations (Scopus)

Targeting cancer stem-like cells of castration-resistant prostate cancer through combinatorial inhibition of MET/nuclear MET and β-Catenin pathways: potential therapeutic intellectual property in prostate cancer treatment

Project Details

Grant Program

Project Description

Keywords

Fingerprint

Carbon nanoparticles induce DNA repair and PARP inhibitor resistance associated with nanozyme activity in cancer cells

Editorial: Molecular mechanisms of epithelial-mesenchymal transition in cancer metastasis

Generation of particle assemblies mimicking enzymatic activity by processing of herbal food: The case of rhizoma polygonati and other natural ingredients in traditional Chinese medicine

Targeting cancer stem-like cells of castration-resistant prostate cancer through combinatorial inhibition of MET/nuclear MET and β-Catenin pathways: potential therapeutic intellectual property in prostate cancer treatment

Project Details

Grant Program

Project Description

Keywords

Fingerprint

Research output

Carbon nanoparticles induce DNA repair and PARP inhibitor resistance associated with nanozyme activity in cancer cells

Editorial: Molecular mechanisms of epithelial-mesenchymal transition in cancer metastasis

Generation of particle assemblies mimicking enzymatic activity by processing of herbal food: The case of rhizoma polygonati and other natural ingredients in traditional Chinese medicine