Three-dimensional patient-specific reconstruction of optic nerve head morphology for risk assessment of glaucoma development and progression

Project: Research project

Call title (Call ID)

ORAU Grant

Project Description

The eyes are one of the most important sensory organs and are specialized for the conversion of lights into electrochemical signals so that our brain can interpret. Glaucoma is an eye disease in which the optic nerve is damaged, and can cause irreversible blindness if it is left untreated [1]. The presumed primary location of the glaucomatous damage is within the optic nerve head (ONH), the site where retinal ganglion cell axons converge to leave the back of the eye and connected to the brain.

Key findings

We anticipate validated three-dimensional ONH morphology reconstruction method to the proposed problems, and clinical data to form patient-specific ocular model for generalization of understanding of biomechanical linkage between ONH morphology, IOP and ocular biomechanics to the etiology and diagnosis of glaucoma, and to form scientifically sound clinical risk assessment guideline for glaucoma diagnosis. The ocular elasticity is known to be stiffened with age [43-47] and that’s mean the older population with stiffened ocular elasticity would be more susceptible to vision loss due to the amplified shear stresses in LC [31]. There is a general recommendation for people aged over 65 to have at least one comprehensive eye examination every year. According to statistics published by the World Bank in 2013 (latest available), there are 504M seniors worldwide. 32M are in Southeast Asia, 43M in North America, 121M in Europe, 123M in China and 1.2M (7% of population) in Kazakhstan. The target consumers and customers of the proposed three-dimensional ONH morphology reconstruction method and the patient-specific ocular model will be the entire population with age over 65 and it has a very big market potential to commercialize the developed algorithm and computational solution.
StatusActive
Effective start/end date1/1/1712/31/20

Fingerprint

Optic Disk
Glaucoma
Eye Diseases
Retinal Ganglion Cells
Brain
Blindness
Optic Nerve
Axons
Light

ASJC

  • Engineering(all)