Understanding the Role of CTHRC1 in Synovial Invasiveness in Rheumatoid Arthritis

  • Kunz, Jeannette (PI)
  • Adilbayeva, Altynay (Postdoctoral scholar (PhD degree holder))
  • Manarbek, Limara (Other Faculty/Researcher)
  • Beeton, Christine (Other Faculty/Researcher)

Project: Monitored by Research Administration

Project Details

Grant Program

Faculty Development Competitive Research Grant Program 2021-2023

Project Description

Purpose of project: The overarching goal of the proposed research is to assess the role of a novel biomarker of rheumatoid arthritis (RA) – Collagen Triple Helix Repeat Containing 1 (CTHRC1) – in joint erosion through the regulation of activation, expansion, and invasion of the arthritic pannus, a special tissue that destructs joints of RA patients. Our proposed research will focus on the role of CTHRC1 in the invasiveness of synoviocytes, the predominant non-immune cells present in synovial tissue that are the key drivers of joint erosion.
StatusActive
Effective start/end date1/1/21 → 12/31/23
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Keywords

  • Rheumatoid Arthritis
  • autoimmunity
  • synoviocytes
  • invasion

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