Renal transplantasyon sonrasi{dotless} ailesel akdeniz ateşi olgusu: Fenotip II' den I'e

Translated title of the contribution: A case of familial mediterranean fever after renal transplantation: From phenotype II to I

Yalçin Solak, Hüseyin Atalay, Ilker Polat, Zeynep Biyik, Abduzhappar Gaipov, Adem Küçük, Süleyman Türk

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Familial Mediterranean fever (FMF) is the prototype of autoinflammatory syndromes. Several factors may trigger the disease including physical and emotional stress, fat-rich diet, and menstruel cycle. Infections and some drugs such as cisplatin may result in a change in cytokine levels and may precipitate attacks. Most cases of FMF presents with typical self-limited attacks including fever and abdominal pain. However, a minority of patients, called as phenotype II, presents with amyloidosis AA-type and/or end-stage renal disease in the absence of clinically recognizable attacks. Immunosupression may precipitate a typical FMF attack, possibly through a change in cytokine balance. Initiation of colchicine treatment in these patients is of utmost importance to prevent amyloidosis involvement of the newly transplanted graft. In this article, we present a rare case of FMF who transformed from phenotype II to phenotype I after renal transplantation, most probably due to the effect of immunosuppressants.

Translated title of the contributionA case of familial mediterranean fever after renal transplantation: From phenotype II to I
Original languageTurkish
Pages (from-to)140-143
Number of pages4
JournalTurkish Journal of Rheumatology
Volume27
Issue number2
DOIs
Publication statusPublished - Jul 30 2012
Externally publishedYes

Keywords

  • Familial mediterranean fever
  • Immunosuppression
  • Phenotype I
  • Phenotype ii
  • Renal transplantation

ASJC Scopus subject areas

  • Rheumatology

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