A CHOP-21 course efficacy in therapy of diffuse large B-cell lymphosarcoma

A. U. Magomedova; S. K. Kravchenko; A. M. Kremenetskaya; E. E. Zvonkov; T. N. Moiseeva; E. E. Zybunova; I. B. Kaplanskaya; R. S. Samoilova; I. A. Vorobyev; Yu Yu Lorie; O. V. Margolin; E. A. Gilyazitdinova; A. V. Gubkin; N. G. Chernova; V. V. Ryzhko; E. G. Gemdzhan

A CHOP-21 course efficacy in therapy of diffuse large B-cell lymphosarcoma

A. U. Magomedova, S. K. Kravchenko, A. M. Kremenetskaya, E. E. Zvonkov, T. N. Moiseeva, E. E. Zybunova, I. B. Kaplanskaya, R. S. Samoilova, I. A. Vorobyev, Yu Yu Lorie, O. V. Margolin, E. A. Gilyazitdinova, A. V. Gubkin, N. G. Chernova, V. V. Ryzhko, E. G. Gemdzhan

Department of Biology

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

Aim. To examine efficacy of polychemotherapy (PCT) CHOP-21 in patients with diffuse large B-cell lymphosarcoma (DLBCL). Material and methods. Fifty-five DLBCL patients received first-line therapy according to CHOP-21 program in 1996-2004. The diagnosis was made by WHO criteria. Results. Initially, 37 patients had lymph node lesions, 18 - nonlymphatic lesions. Complete remissions were achieved in 49% (56.7% in nodal lesions, 33.3% in extranodal ones). Overall 5-year survival was 35%, event-free - 25%, for patients with nodal lesions - 36 and 32%, respectively, extranodal lesions - 35 and 22%, respectively. Overall 5-year and event-free survival in patients with local lesions was 85 and 75%, generalized - 25 and 20%, respectively. In patients with involvement of the gastrointestinal tract 3-year overall and event-free survival reached 50 and 45%. Event-free survival was not seen in patients with extranodal lesions of other locations in overall 3-year survival 45%. Conclusion. PCT program CHOP-21 was effective in DLBCL patients with local nodular lesions except cases with large-size tumors, invasion in the adjacent organs and tissues and isolated gastric lesion.

Original language	English
Pages (from-to)	58-61
Number of pages	4
Journal	Terapevticheskii Arkhiv
Volume	77
Issue number	7
Publication status	Published - Aug 22 2005

Keywords

CHOP-21
Diffuse large B-cell lymphosarcoma
Extranodal
Generalized lesion
Local
Nodal
Survival

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism

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Magomedova, A. U., Kravchenko, S. K., Kremenetskaya, A. M., Zvonkov, E. E., Moiseeva, T. N., Zybunova, E. E., Kaplanskaya, I. B., Samoilova, R. S., Vorobyev, I. A., Lorie, Y. Y., Margolin, O. V., Gilyazitdinova, E. A., Gubkin, A. V., Chernova, N. G., Ryzhko, V. V., & Gemdzhan, E. G. (2005). A CHOP-21 course efficacy in therapy of diffuse large B-cell lymphosarcoma. Terapevticheskii Arkhiv, 77(7), 58-61.

A CHOP-21 course efficacy in therapy of diffuse large B-cell lymphosarcoma. / Magomedova, A. U.; Kravchenko, S. K.; Kremenetskaya, A. M.; Zvonkov, E. E.; Moiseeva, T. N.; Zybunova, E. E.; Kaplanskaya, I. B.; Samoilova, R. S.; Vorobyev, I. A.; Lorie, Yu Yu; Margolin, O. V.; Gilyazitdinova, E. A.; Gubkin, A. V.; Chernova, N. G.; Ryzhko, V. V.; Gemdzhan, E. G.

In: Terapevticheskii Arkhiv, Vol. 77, No. 7, 22.08.2005, p. 58-61.

Research output: Contribution to journal › Article › peer-review

Magomedova, AU, Kravchenko, SK, Kremenetskaya, AM, Zvonkov, EE, Moiseeva, TN, Zybunova, EE, Kaplanskaya, IB, Samoilova, RS, Vorobyev, IA, Lorie, YY, Margolin, OV, Gilyazitdinova, EA, Gubkin, AV, Chernova, NG, Ryzhko, VV & Gemdzhan, EG 2005, 'A CHOP-21 course efficacy in therapy of diffuse large B-cell lymphosarcoma', Terapevticheskii Arkhiv, vol. 77, no. 7, pp. 58-61.

Magomedova, A. U. ; Kravchenko, S. K. ; Kremenetskaya, A. M. ; Zvonkov, E. E. ; Moiseeva, T. N. ; Zybunova, E. E. ; Kaplanskaya, I. B. ; Samoilova, R. S. ; Vorobyev, I. A. ; Lorie, Yu Yu ; Margolin, O. V. ; Gilyazitdinova, E. A. ; Gubkin, A. V. ; Chernova, N. G. ; Ryzhko, V. V. ; Gemdzhan, E. G. / A CHOP-21 course efficacy in therapy of diffuse large B-cell lymphosarcoma. In: Terapevticheskii Arkhiv. 2005 ; Vol. 77, No. 7. pp. 58-61.

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title = "A CHOP-21 course efficacy in therapy of diffuse large B-cell lymphosarcoma",

abstract = "Aim. To examine efficacy of polychemotherapy (PCT) CHOP-21 in patients with diffuse large B-cell lymphosarcoma (DLBCL). Material and methods. Fifty-five DLBCL patients received first-line therapy according to CHOP-21 program in 1996-2004. The diagnosis was made by WHO criteria. Results. Initially, 37 patients had lymph node lesions, 18 - nonlymphatic lesions. Complete remissions were achieved in 49% (56.7% in nodal lesions, 33.3% in extranodal ones). Overall 5-year survival was 35%, event-free - 25%, for patients with nodal lesions - 36 and 32%, respectively, extranodal lesions - 35 and 22%, respectively. Overall 5-year and event-free survival in patients with local lesions was 85 and 75%, generalized - 25 and 20%, respectively. In patients with involvement of the gastrointestinal tract 3-year overall and event-free survival reached 50 and 45%. Event-free survival was not seen in patients with extranodal lesions of other locations in overall 3-year survival 45%. Conclusion. PCT program CHOP-21 was effective in DLBCL patients with local nodular lesions except cases with large-size tumors, invasion in the adjacent organs and tissues and isolated gastric lesion.",

keywords = "CHOP-21, Diffuse large B-cell lymphosarcoma, Extranodal, Generalized lesion, Local, Nodal, Survival",

author = "Magomedova, {A. U.} and Kravchenko, {S. K.} and Kremenetskaya, {A. M.} and Zvonkov, {E. E.} and Moiseeva, {T. N.} and Zybunova, {E. E.} and Kaplanskaya, {I. B.} and Samoilova, {R. S.} and Vorobyev, {I. A.} and Lorie, {Yu Yu} and Margolin, {O. V.} and Gilyazitdinova, {E. A.} and Gubkin, {A. V.} and Chernova, {N. G.} and Ryzhko, {V. V.} and Gemdzhan, {E. G.}",

year = "2005",

month = aug,

day = "22",

language = "English",

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T1 - A CHOP-21 course efficacy in therapy of diffuse large B-cell lymphosarcoma

AU - Magomedova, A. U.

AU - Kravchenko, S. K.

AU - Kremenetskaya, A. M.

AU - Zvonkov, E. E.

AU - Moiseeva, T. N.

AU - Zybunova, E. E.

AU - Kaplanskaya, I. B.

AU - Samoilova, R. S.

AU - Vorobyev, I. A.

AU - Lorie, Yu Yu

AU - Margolin, O. V.

AU - Gilyazitdinova, E. A.

AU - Gubkin, A. V.

AU - Chernova, N. G.

AU - Ryzhko, V. V.

AU - Gemdzhan, E. G.

PY - 2005/8/22

Y1 - 2005/8/22

N2 - Aim. To examine efficacy of polychemotherapy (PCT) CHOP-21 in patients with diffuse large B-cell lymphosarcoma (DLBCL). Material and methods. Fifty-five DLBCL patients received first-line therapy according to CHOP-21 program in 1996-2004. The diagnosis was made by WHO criteria. Results. Initially, 37 patients had lymph node lesions, 18 - nonlymphatic lesions. Complete remissions were achieved in 49% (56.7% in nodal lesions, 33.3% in extranodal ones). Overall 5-year survival was 35%, event-free - 25%, for patients with nodal lesions - 36 and 32%, respectively, extranodal lesions - 35 and 22%, respectively. Overall 5-year and event-free survival in patients with local lesions was 85 and 75%, generalized - 25 and 20%, respectively. In patients with involvement of the gastrointestinal tract 3-year overall and event-free survival reached 50 and 45%. Event-free survival was not seen in patients with extranodal lesions of other locations in overall 3-year survival 45%. Conclusion. PCT program CHOP-21 was effective in DLBCL patients with local nodular lesions except cases with large-size tumors, invasion in the adjacent organs and tissues and isolated gastric lesion.

AB - Aim. To examine efficacy of polychemotherapy (PCT) CHOP-21 in patients with diffuse large B-cell lymphosarcoma (DLBCL). Material and methods. Fifty-five DLBCL patients received first-line therapy according to CHOP-21 program in 1996-2004. The diagnosis was made by WHO criteria. Results. Initially, 37 patients had lymph node lesions, 18 - nonlymphatic lesions. Complete remissions were achieved in 49% (56.7% in nodal lesions, 33.3% in extranodal ones). Overall 5-year survival was 35%, event-free - 25%, for patients with nodal lesions - 36 and 32%, respectively, extranodal lesions - 35 and 22%, respectively. Overall 5-year and event-free survival in patients with local lesions was 85 and 75%, generalized - 25 and 20%, respectively. In patients with involvement of the gastrointestinal tract 3-year overall and event-free survival reached 50 and 45%. Event-free survival was not seen in patients with extranodal lesions of other locations in overall 3-year survival 45%. Conclusion. PCT program CHOP-21 was effective in DLBCL patients with local nodular lesions except cases with large-size tumors, invasion in the adjacent organs and tissues and isolated gastric lesion.

KW - CHOP-21

KW - Diffuse large B-cell lymphosarcoma

KW - Extranodal

KW - Generalized lesion

KW - Local

KW - Nodal

KW - Survival

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