A new formalism for the quantification of tissue perfusion by the destruction-replenishment method in contrast ultrasound imaging

Marcel Arditi, Peter J A Frinking, Xiang Zhou, Nicolas G. Rognin

Research output: Contribution to journalArticle

106 Citations (Scopus)

Abstract

A now formalism is presented for the destruction-replenishment perfusion quantification approach at low mechanical index. On the basis of physical considerations, best-fit methods should be applied using perfusion functions with S-shape characteristics. Those functions are first described for the case of a geometry with a single flow velocity, then extended to the case of vascular beds with blood vessels having multiple flow velocity values and directions. The principles guiding the analysis are, on one hand, a linearization of video echo signals to overcome the log-compression of tho imaging instrument, and, on the other hand, the spatial distribution of tho transmitreceive ultrasound boam In the elevation direction. An in vitro model also is described; it was used to confirm experimentally the validity of the approach using a commercial contrast agent. The approach was implemented in the form of a computer program, taking as input a sequence of contrast-specific images, as well as parameters related to the ultrasound imaging equipment used. The generated output is either flow-parameter values computed in regions-of-interest, or parametric flow-images (e.g., moan velocity, mean transit time, mean flow, flow variance, or skewness). This approach thus establishes a base for extracting information about the morphology of vascular beds in vivo, and could allow absolute quantification provided that appropriate instrument calibration is implemented.

Original languageEnglish
Pages (from-to)1118-1129
Number of pages12
JournalIEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
Volume53
Issue number6
DOIs
Publication statusPublished - Jun 2006
Externally publishedYes

Fingerprint

replenishment
Flow velocity
destruction
Ultrasonics
Tissue
formalism
Imaging techniques
Blood vessels
Linearization
Spatial distribution
Computer program listings
beds
flow velocity
Calibration
skewness
Geometry
blood vessels
transit time
linearization
echoes

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Acoustics and Ultrasonics

Cite this

A new formalism for the quantification of tissue perfusion by the destruction-replenishment method in contrast ultrasound imaging. / Arditi, Marcel; Frinking, Peter J A; Zhou, Xiang; Rognin, Nicolas G.

In: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, Vol. 53, No. 6, 06.2006, p. 1118-1129.

Research output: Contribution to journalArticle

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