TY - JOUR
T1 - A new insight on the radioprotective potential of epsilon-aminocaproic acid
AU - Saliev, Timur
AU - Baiskhanova, Dinara
AU - Beznosko, Dmitriy
AU - Begimbetova, Dinara
AU - Umbayev, Bauyrzhan
AU - Nurgozhin, Talgat
AU - Fakhradiyev, Ildar
AU - Tanabayev, Baimakhan
AU - Pavalkis, Dainius
N1 - Publisher Copyright:
© 2020 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2020
Y1 - 2020
N2 - Background and objectives: The aim of the study was to scrutinize the ability of epsilon-aminocaproic acid (EACA) to prevent radiation-induced damage to human cells. Materials and Methods: Human peripheral blood mononuclear cells (PBMCs) were exposed to ionizing radiation at three low doses (22.62 mGy, 45.27 mGy, and 67.88 mGy) in the presence of EACA at the concentration of 50 ng/mL. Results: EACA was able to prevent cell death induced by low-dose X-ray radiation and suppress the formation of reactive oxygen species (ROS). EACA also demonstrated a capacity to protect DNA from radiation-induced damage. The data indicated that EACA is capable of suppression of radiation-induced apoptosis. Comparative tests of antioxidative activity of EACA and a range of free radical scavengers showed an ability of EACA to effectively inhibit the generation of ROS. Conclusions: This study showed that the pretreatment of PBMCs with EACA is able to protect the cells from radiation-elicited damage, including free radicals’ formation, DNA damage, and apoptosis.
AB - Background and objectives: The aim of the study was to scrutinize the ability of epsilon-aminocaproic acid (EACA) to prevent radiation-induced damage to human cells. Materials and Methods: Human peripheral blood mononuclear cells (PBMCs) were exposed to ionizing radiation at three low doses (22.62 mGy, 45.27 mGy, and 67.88 mGy) in the presence of EACA at the concentration of 50 ng/mL. Results: EACA was able to prevent cell death induced by low-dose X-ray radiation and suppress the formation of reactive oxygen species (ROS). EACA also demonstrated a capacity to protect DNA from radiation-induced damage. The data indicated that EACA is capable of suppression of radiation-induced apoptosis. Comparative tests of antioxidative activity of EACA and a range of free radical scavengers showed an ability of EACA to effectively inhibit the generation of ROS. Conclusions: This study showed that the pretreatment of PBMCs with EACA is able to protect the cells from radiation-elicited damage, including free radicals’ formation, DNA damage, and apoptosis.
KW - Apoptosis
KW - DNA damage
KW - Epsilon-aminocaproic acid
KW - Protection
KW - Radiation
KW - Reactive oxygen species
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U2 - 10.3390/medicina56120663
DO - 10.3390/medicina56120663
M3 - Article
C2 - 33266046
AN - SCOPUS:85096981294
SN - 1010-660X
VL - 56
SP - 1
EP - 19
JO - Medicina (Lithuania)
JF - Medicina (Lithuania)
IS - 12
M1 - 663
ER -