A possible mutation that enables H1N1 influenza A virus to escape antibody recognition

Chinh T.T. Su, Stephanus D. Handoko, Chee Keong Kwoh, Christian Schönbach, Xiaoli Li

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

The H1N1 influenza A 2009 pandemic caused a global concern as it has killed more than 18,000 people worldwide so far. Studies that have found cross-neutralizing antibodies between the 1918 and 2009 pandemic flu elicit a basis of pre-existing immunity against the 2009 H1N1 virus in old population. The cross-reactivity occurs due to conserved antigenic epitopes shared between the two pandemic viruses. However, evolutionary mutation can enable the virus to elude human immunity system, making these antibodies probably no longer effective. In our study, we found that a possible mutation in B-cell epitope (the sequence PNHDSNKG) could be the chance for the virus to escape the 1918 antibody recognition. Hence, this finding can be helpful for further vaccine designs against the H1N1 2009 influenza A virus.

Original languageEnglish
Title of host publicationProceedings - 2010 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2010
Pages81-84
Number of pages4
DOIs
Publication statusPublished - Dec 1 2010
Event2010 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2010 - Hong Kong, China
Duration: Dec 18 2010Dec 21 2010

Publication series

NameProceedings - 2010 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2010

Other

Other2010 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2010
CountryChina
CityHong Kong
Period12/18/1012/21/10

Keywords

  • Antibody recognition
  • H1N1 influenza A virus
  • Mutation
  • Protein docking

ASJC Scopus subject areas

  • Biomedical Engineering
  • Health Informatics

Fingerprint Dive into the research topics of 'A possible mutation that enables H1N1 influenza A virus to escape antibody recognition'. Together they form a unique fingerprint.

  • Cite this

    Su, C. T. T., Handoko, S. D., Kwoh, C. K., Schönbach, C., & Li, X. (2010). A possible mutation that enables H1N1 influenza A virus to escape antibody recognition. In Proceedings - 2010 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2010 (pp. 81-84). [5706541] (Proceedings - 2010 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2010). https://doi.org/10.1109/BIBM.2010.5706541