A stomatin-domain protein essential for touch sensation in the mouse

Christiane Wetzel, Jing Hu, Dieter Riethmacher, Anne Benckendorff, Lena Harder, Andreas Eilers, Rabih Moshourab, Alexey Kozlenkov, Dominika Labuz, Ombretta Caspani, Bettina Erdmann, Halina Machelska, Paul A. Heppenstall, Gary R. Lewin

Research output: Contribution to journalArticle

141 Citations (Scopus)

Abstract

Touch and mechanical pain are first detected at our largest sensory surface, the skin. The cell bodies of sensory neurons that detect such stimuli are located in the dorsal root ganglia, and subtypes of these neurons are specialized to detect specific modalities of mechanical stimuli. Molecules have been identified that are necessary for mechanosensation in invertebrates but so far not in mammals. In Caenorhabditis elegans, mec-2 is one of several genes identified in a screen for touch insensitivity and encodes an integral membrane protein with a stomatin homology domain. Here we show that about 35% of skin mechanoreceptors do not respond to mechanical stimuli in mice with a mutation in stomatin-like protein 3 (SLP3, also called Stoml3), a mammalian mec-2 homologue that is expressed in sensory neurons. In addition, mechanosensitive ion channels found in many sensory neurons do not function without SLP3. Tactile-driven behaviours are also impaired in SLP3 mutant mice, including touch-evoked pain caused by neuropathic injury. SLP3 is therefore indispensable for the function of a subset of cutaneous mechanoreceptors, and our data support the idea that this protein is an essential subunit of a mammalian mechanotransducer.

Original languageEnglish
Pages (from-to)206-209
Number of pages4
JournalNature
Volume445
Issue number7124
DOIs
Publication statusPublished - Jan 11 2007
Externally publishedYes

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Touch
Sensory Receptor Cells
Mechanoreceptors
Skin
Caenorhabditis elegans
Spinal Ganglia
Neuralgia
Invertebrates
Ion Channels
Mammals
Membrane Proteins
Proteins
Neurons
Pain
Mutation
Protein Domains
Wounds and Injuries
Genes

ASJC Scopus subject areas

  • General

Cite this

Wetzel, C., Hu, J., Riethmacher, D., Benckendorff, A., Harder, L., Eilers, A., ... Lewin, G. R. (2007). A stomatin-domain protein essential for touch sensation in the mouse. Nature, 445(7124), 206-209. https://doi.org/10.1038/nature05394

A stomatin-domain protein essential for touch sensation in the mouse. / Wetzel, Christiane; Hu, Jing; Riethmacher, Dieter; Benckendorff, Anne; Harder, Lena; Eilers, Andreas; Moshourab, Rabih; Kozlenkov, Alexey; Labuz, Dominika; Caspani, Ombretta; Erdmann, Bettina; Machelska, Halina; Heppenstall, Paul A.; Lewin, Gary R.

In: Nature, Vol. 445, No. 7124, 11.01.2007, p. 206-209.

Research output: Contribution to journalArticle

Wetzel, C, Hu, J, Riethmacher, D, Benckendorff, A, Harder, L, Eilers, A, Moshourab, R, Kozlenkov, A, Labuz, D, Caspani, O, Erdmann, B, Machelska, H, Heppenstall, PA & Lewin, GR 2007, 'A stomatin-domain protein essential for touch sensation in the mouse', Nature, vol. 445, no. 7124, pp. 206-209. https://doi.org/10.1038/nature05394
Wetzel C, Hu J, Riethmacher D, Benckendorff A, Harder L, Eilers A et al. A stomatin-domain protein essential for touch sensation in the mouse. Nature. 2007 Jan 11;445(7124):206-209. https://doi.org/10.1038/nature05394
Wetzel, Christiane ; Hu, Jing ; Riethmacher, Dieter ; Benckendorff, Anne ; Harder, Lena ; Eilers, Andreas ; Moshourab, Rabih ; Kozlenkov, Alexey ; Labuz, Dominika ; Caspani, Ombretta ; Erdmann, Bettina ; Machelska, Halina ; Heppenstall, Paul A. ; Lewin, Gary R. / A stomatin-domain protein essential for touch sensation in the mouse. In: Nature. 2007 ; Vol. 445, No. 7124. pp. 206-209.
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