TY - JOUR
T1 - A walk around the A 3-coupling
AU - Peshkov, Vsevolod A.
AU - Pereshivko, Olga P.
AU - Van Der Eycken, Erik V.
PY - 2012/5/21
Y1 - 2012/5/21
N2 - In recent years, the transition-metal catalyzed three-component coupling of an aldehyde, an alkyne and an amine, commonly called A 3-coupling, has been established as a convenient and general approach towards propargylamines. Furthermore, the A 3-coupling has found a broad application as a key step in the construction of various nitrogen-containing heterocycles, biologically active compounds and natural products. Several interesting modifications of the A 3-coupling as well as different tandem reactions involving A 3-coupling have been developed. This tutorial review aims to highlight the current achievements in the field of A 3-couplings and related transformations.
AB - In recent years, the transition-metal catalyzed three-component coupling of an aldehyde, an alkyne and an amine, commonly called A 3-coupling, has been established as a convenient and general approach towards propargylamines. Furthermore, the A 3-coupling has found a broad application as a key step in the construction of various nitrogen-containing heterocycles, biologically active compounds and natural products. Several interesting modifications of the A 3-coupling as well as different tandem reactions involving A 3-coupling have been developed. This tutorial review aims to highlight the current achievements in the field of A 3-couplings and related transformations.
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U2 - 10.1039/c2cs15356d
DO - 10.1039/c2cs15356d
M3 - Review article
AN - SCOPUS:84860470639
VL - 41
SP - 3790
EP - 3807
JO - Chemical Society Reviews
JF - Chemical Society Reviews
SN - 0306-0012
IS - 10
ER -