A walk around the A 3-coupling

Vsevolod A. Peshkov, Olga P. Pereshivko, Erik V. Van Der Eycken

Research output: Contribution to journalReview articlepeer-review

478 Citations (Scopus)


In recent years, the transition-metal catalyzed three-component coupling of an aldehyde, an alkyne and an amine, commonly called A 3-coupling, has been established as a convenient and general approach towards propargylamines. Furthermore, the A 3-coupling has found a broad application as a key step in the construction of various nitrogen-containing heterocycles, biologically active compounds and natural products. Several interesting modifications of the A 3-coupling as well as different tandem reactions involving A 3-coupling have been developed. This tutorial review aims to highlight the current achievements in the field of A 3-couplings and related transformations.

Original languageEnglish
Pages (from-to)3790-3807
Number of pages18
JournalChemical Society Reviews
Issue number10
Publication statusPublished - May 21 2012
Externally publishedYes

ASJC Scopus subject areas

  • Chemistry(all)

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