A walk around the A 3-coupling

Vsevolod A. Peshkov; Olga P. Pereshivko; Erik V. Van Der Eycken

doi:10.1039/c2cs15356d

A walk around the A ³-coupling

Vsevolod A. Peshkov, Olga P. Pereshivko, Erik V. Van Der Eycken

Research output: Contribution to journal › Review article › peer-review

478 Citations (Scopus)

Abstract

In recent years, the transition-metal catalyzed three-component coupling of an aldehyde, an alkyne and an amine, commonly called A ³-coupling, has been established as a convenient and general approach towards propargylamines. Furthermore, the A ³-coupling has found a broad application as a key step in the construction of various nitrogen-containing heterocycles, biologically active compounds and natural products. Several interesting modifications of the A ³-coupling as well as different tandem reactions involving A ³-coupling have been developed. This tutorial review aims to highlight the current achievements in the field of A ³-couplings and related transformations.

Original language	English
Pages (from-to)	3790-3807
Number of pages	18
Journal	Chemical Society Reviews
Volume	41
Issue number	10
DOIs	https://doi.org/10.1039/c2cs15356d
Publication status	Published - May 21 2012
Externally published	Yes

ASJC Scopus subject areas

Chemistry(all)

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AU - Peshkov, Vsevolod A.

AU - Pereshivko, Olga P.

AU - Van Der Eycken, Erik V.

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Y1 - 2012/5/21

N2 - In recent years, the transition-metal catalyzed three-component coupling of an aldehyde, an alkyne and an amine, commonly called A 3-coupling, has been established as a convenient and general approach towards propargylamines. Furthermore, the A 3-coupling has found a broad application as a key step in the construction of various nitrogen-containing heterocycles, biologically active compounds and natural products. Several interesting modifications of the A 3-coupling as well as different tandem reactions involving A 3-coupling have been developed. This tutorial review aims to highlight the current achievements in the field of A 3-couplings and related transformations.

AB - In recent years, the transition-metal catalyzed three-component coupling of an aldehyde, an alkyne and an amine, commonly called A 3-coupling, has been established as a convenient and general approach towards propargylamines. Furthermore, the A 3-coupling has found a broad application as a key step in the construction of various nitrogen-containing heterocycles, biologically active compounds and natural products. Several interesting modifications of the A 3-coupling as well as different tandem reactions involving A 3-coupling have been developed. This tutorial review aims to highlight the current achievements in the field of A 3-couplings and related transformations.

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