Aberrant E-cadherin and α-catenin expression in prostate cancer

Correlation with patient survival

Paul J M Richmond, Anastasios J. Karayiannakis, Akira Nagafuchi, Amir V. Kaisary, Massimo Pignatelli

Research output: Contribution to journalArticle

204 Citations (Scopus)

Abstract

E-cadherin maintains the normal differentiated phenotype in epithelial cells; this function is partly mediated by α-catenin, which links E-cadherin to the cell cytoskeleton. Dysfunction of E-cadherin in vitro and in vivo is associated with an invasive phenotype. However, the role of α-catenin is largely undetermined. We analyzed the expression of E-cadherin and α- catenin in prostate cancer to assess the relationship of abnormal expression to stage, grade and survival. E-cadherin expression was evaluated in 99 prostate cancers. In 79 of those specimens, α-catenin was also assessed. In benign prostatic epithelium, both E-cadherin and α-catenin were expressed uniformly at the cell membrane. Abnormal E-cadherin expression was found in 56% of cancer specimens, whereas α-catenin expression was abnormal in 42%. Abnormal expression of each molecule was significantly correlated with Gleason score (P <0.0001) and the ratio of resection chippings infiltrated by tumor (P <0.0001). E-cadherin expression was also associated with the extent of disease on the initial bone scan (P = 0.017). Univariate analysis showed significantly lower survival rate for patients with abnormal E- eadherin (P = 0.0003) or α-catenin expression (P = 0.031). Multivariate regression analysis showed that the prognostic value of E-cadherin was independent of tumor grade but not of metastasis. These results suggest that perturbation of cell-cell adhesion is involved in the progression of prostate cancer and that analysis of E-cadherin expression may be clinically useful.

Original languageEnglish
Pages (from-to)3189-3193
Number of pages5
JournalCancer Research
Volume57
Issue number15
Publication statusPublished - 1997
Externally publishedYes

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Catenins
Cadherins
Prostatic Neoplasms
Survival
Phenotype
Neoplasms
Neoplasm Grading
Cytoskeleton
Cell Adhesion
Multivariate Analysis
Survival Rate
Epithelium
Epithelial Cells
Regression Analysis
Cell Membrane
Neoplasm Metastasis
Bone and Bones

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Richmond, P. J. M., Karayiannakis, A. J., Nagafuchi, A., Kaisary, A. V., & Pignatelli, M. (1997). Aberrant E-cadherin and α-catenin expression in prostate cancer: Correlation with patient survival. Cancer Research, 57(15), 3189-3193.

Aberrant E-cadherin and α-catenin expression in prostate cancer : Correlation with patient survival. / Richmond, Paul J M; Karayiannakis, Anastasios J.; Nagafuchi, Akira; Kaisary, Amir V.; Pignatelli, Massimo.

In: Cancer Research, Vol. 57, No. 15, 1997, p. 3189-3193.

Research output: Contribution to journalArticle

Richmond, PJM, Karayiannakis, AJ, Nagafuchi, A, Kaisary, AV & Pignatelli, M 1997, 'Aberrant E-cadherin and α-catenin expression in prostate cancer: Correlation with patient survival', Cancer Research, vol. 57, no. 15, pp. 3189-3193.
Richmond, Paul J M ; Karayiannakis, Anastasios J. ; Nagafuchi, Akira ; Kaisary, Amir V. ; Pignatelli, Massimo. / Aberrant E-cadherin and α-catenin expression in prostate cancer : Correlation with patient survival. In: Cancer Research. 1997 ; Vol. 57, No. 15. pp. 3189-3193.
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