Abnormal α-catenin expression in invasive breast cancer correlates with poor patient survival

L. Nakopoulou, H. Gakiopoulou-Givalou, A. J. Karayiannakis, I. Giannopoulou, A. Keramopoulos, P. Davaris, M. Pignatelli

Research output: Contribution to journalArticle

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Abstract

Aims: α-Catenin is a member of the E-cadherin-catenin family of adhesion molecules whose role is essential for the function of the E-cadherin complex. In this study, we have evaluated the expression of α-catenin but also of the other catenins (β-, γ- and p120-catenin) and E-cadherin in invasive breast cancer and statistically analysed these expressions with known clinicopathological parameters, c-erbB-2 onco-protein expression and patient survival. Methods and results: Abnormal E-cadherin and β-catenin expression, especially loss of expression, was associated with lobular histological type of breast carcinomas (P = 0.03 and P = 0.01, respectively). Abnormal E-cadherin and α-catenin expression was associated with high histological grade ductal carcinomas (P = 0.01 and P = 0.03, respectively). Abnormal E-cadherin and β-catenin expression was correlated with lymph node metastases (P = 0.02 and P = 0.05, respectively), while abnormal α- and β-catenin were correlated with the advanced stage of the disease (P = 0.04 and P = 0.05, respectively). Abnormal p120-catenin expression was associated with loss of PR (P = 0.008). Survival analysis demonstrated a statistically significant association between abnormal α-catenin expression and poor patient survival (P = 0.02). When survival analysis was performed according to the different patterns of abnormal expression, statistically significant associations were seen between cytoplasmic α- and β-catenin expression and poor survival (P = 0.006 and P = 0.04, respectively). Conclusions: α-Catenin, especially its cytoplasmic expression, seems to be a more sensitive prognostic marker than the other members of the E-cadherin complex in invasive breast cancer.

Original languageEnglish
Pages (from-to)536-546
Number of pages11
JournalHistopathology
Volume40
Issue number6
DOIs
Publication statusPublished - 2002
Externally publishedYes

Fingerprint

Catenins
Breast Neoplasms
Cadherins
Survival
Survival Analysis
ErbB-2 Receptor
Ductal Carcinoma
Lymph Nodes

Keywords

  • Catenins (α-, β-, γ-, p120)
  • E-cadherin
  • Invasive breast cancer

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine
  • Cell Biology

Cite this

Nakopoulou, L., Gakiopoulou-Givalou, H., Karayiannakis, A. J., Giannopoulou, I., Keramopoulos, A., Davaris, P., & Pignatelli, M. (2002). Abnormal α-catenin expression in invasive breast cancer correlates with poor patient survival. Histopathology, 40(6), 536-546. https://doi.org/10.1046/j.1365-2559.2002.01392.x

Abnormal α-catenin expression in invasive breast cancer correlates with poor patient survival. / Nakopoulou, L.; Gakiopoulou-Givalou, H.; Karayiannakis, A. J.; Giannopoulou, I.; Keramopoulos, A.; Davaris, P.; Pignatelli, M.

In: Histopathology, Vol. 40, No. 6, 2002, p. 536-546.

Research output: Contribution to journalArticle

Nakopoulou, L, Gakiopoulou-Givalou, H, Karayiannakis, AJ, Giannopoulou, I, Keramopoulos, A, Davaris, P & Pignatelli, M 2002, 'Abnormal α-catenin expression in invasive breast cancer correlates with poor patient survival', Histopathology, vol. 40, no. 6, pp. 536-546. https://doi.org/10.1046/j.1365-2559.2002.01392.x
Nakopoulou L, Gakiopoulou-Givalou H, Karayiannakis AJ, Giannopoulou I, Keramopoulos A, Davaris P et al. Abnormal α-catenin expression in invasive breast cancer correlates with poor patient survival. Histopathology. 2002;40(6):536-546. https://doi.org/10.1046/j.1365-2559.2002.01392.x
Nakopoulou, L. ; Gakiopoulou-Givalou, H. ; Karayiannakis, A. J. ; Giannopoulou, I. ; Keramopoulos, A. ; Davaris, P. ; Pignatelli, M. / Abnormal α-catenin expression in invasive breast cancer correlates with poor patient survival. In: Histopathology. 2002 ; Vol. 40, No. 6. pp. 536-546.
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abstract = "Aims: α-Catenin is a member of the E-cadherin-catenin family of adhesion molecules whose role is essential for the function of the E-cadherin complex. In this study, we have evaluated the expression of α-catenin but also of the other catenins (β-, γ- and p120-catenin) and E-cadherin in invasive breast cancer and statistically analysed these expressions with known clinicopathological parameters, c-erbB-2 onco-protein expression and patient survival. Methods and results: Abnormal E-cadherin and β-catenin expression, especially loss of expression, was associated with lobular histological type of breast carcinomas (P = 0.03 and P = 0.01, respectively). Abnormal E-cadherin and α-catenin expression was associated with high histological grade ductal carcinomas (P = 0.01 and P = 0.03, respectively). Abnormal E-cadherin and β-catenin expression was correlated with lymph node metastases (P = 0.02 and P = 0.05, respectively), while abnormal α- and β-catenin were correlated with the advanced stage of the disease (P = 0.04 and P = 0.05, respectively). Abnormal p120-catenin expression was associated with loss of PR (P = 0.008). Survival analysis demonstrated a statistically significant association between abnormal α-catenin expression and poor patient survival (P = 0.02). When survival analysis was performed according to the different patterns of abnormal expression, statistically significant associations were seen between cytoplasmic α- and β-catenin expression and poor survival (P = 0.006 and P = 0.04, respectively). Conclusions: α-Catenin, especially its cytoplasmic expression, seems to be a more sensitive prognostic marker than the other members of the E-cadherin complex in invasive breast cancer.",
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AU - Nakopoulou, L.

AU - Gakiopoulou-Givalou, H.

AU - Karayiannakis, A. J.

AU - Giannopoulou, I.

AU - Keramopoulos, A.

AU - Davaris, P.

AU - Pignatelli, M.

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N2 - Aims: α-Catenin is a member of the E-cadherin-catenin family of adhesion molecules whose role is essential for the function of the E-cadherin complex. In this study, we have evaluated the expression of α-catenin but also of the other catenins (β-, γ- and p120-catenin) and E-cadherin in invasive breast cancer and statistically analysed these expressions with known clinicopathological parameters, c-erbB-2 onco-protein expression and patient survival. Methods and results: Abnormal E-cadherin and β-catenin expression, especially loss of expression, was associated with lobular histological type of breast carcinomas (P = 0.03 and P = 0.01, respectively). Abnormal E-cadherin and α-catenin expression was associated with high histological grade ductal carcinomas (P = 0.01 and P = 0.03, respectively). Abnormal E-cadherin and β-catenin expression was correlated with lymph node metastases (P = 0.02 and P = 0.05, respectively), while abnormal α- and β-catenin were correlated with the advanced stage of the disease (P = 0.04 and P = 0.05, respectively). Abnormal p120-catenin expression was associated with loss of PR (P = 0.008). Survival analysis demonstrated a statistically significant association between abnormal α-catenin expression and poor patient survival (P = 0.02). When survival analysis was performed according to the different patterns of abnormal expression, statistically significant associations were seen between cytoplasmic α- and β-catenin expression and poor survival (P = 0.006 and P = 0.04, respectively). Conclusions: α-Catenin, especially its cytoplasmic expression, seems to be a more sensitive prognostic marker than the other members of the E-cadherin complex in invasive breast cancer.

AB - Aims: α-Catenin is a member of the E-cadherin-catenin family of adhesion molecules whose role is essential for the function of the E-cadherin complex. In this study, we have evaluated the expression of α-catenin but also of the other catenins (β-, γ- and p120-catenin) and E-cadherin in invasive breast cancer and statistically analysed these expressions with known clinicopathological parameters, c-erbB-2 onco-protein expression and patient survival. Methods and results: Abnormal E-cadherin and β-catenin expression, especially loss of expression, was associated with lobular histological type of breast carcinomas (P = 0.03 and P = 0.01, respectively). Abnormal E-cadherin and α-catenin expression was associated with high histological grade ductal carcinomas (P = 0.01 and P = 0.03, respectively). Abnormal E-cadherin and β-catenin expression was correlated with lymph node metastases (P = 0.02 and P = 0.05, respectively), while abnormal α- and β-catenin were correlated with the advanced stage of the disease (P = 0.04 and P = 0.05, respectively). Abnormal p120-catenin expression was associated with loss of PR (P = 0.008). Survival analysis demonstrated a statistically significant association between abnormal α-catenin expression and poor patient survival (P = 0.02). When survival analysis was performed according to the different patterns of abnormal expression, statistically significant associations were seen between cytoplasmic α- and β-catenin expression and poor survival (P = 0.006 and P = 0.04, respectively). Conclusions: α-Catenin, especially its cytoplasmic expression, seems to be a more sensitive prognostic marker than the other members of the E-cadherin complex in invasive breast cancer.

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