Abnormal expression of p120 correlates with poor survival in patients with bladder cancer

K. N. Syrigos, A. Karayiannakis, E. I. Syrigou, K. Harrington, M. Pignatelli

Research output: Contribution to journalArticlepeer-review

32 Citations (Scopus)

Abstract

p120 is a cytoplasmic molecule closely associated with the Ca2+- dependent cell-cell adhesion molecule E-cadherin, by forming complexes between the cytoplasmic domain of E-cadherin and the cytoskeleton. Although it has been shown that loss or downregulation of E-cadherin is associated with an invasive and poorly differentiated phenotype in several tumours, there is very little information available concerning p120 expression in malignant disease. We used an avidin-biotin immunoperoxidase technique to examine the immunoreactivity and cellular localisation of p120 and E-cadherin in 68 transitional cell carcinomas (TCC) and 14 normal bladder biopsies and correlated these results with pathological and clinical parameters. E- cadherin and p120 were expressed in a normal membranous pattern in all normal bladder epithelium specimens. Loss of normal surface E-cadherin and p120 expression was found in 52/68 (76%) and 57/68 (84%) tumours, respectively. There was a significant correlation between the loss of normal membranous expression of p120 and increased grade (P<0.001) and T stage (P<0.001). The abnormal expression of p120 was correlated with poor survival (P<0.05). Our data indicate that the E-cadherin-p120 complex may be a useful prognostic marker in bladder cancer.

Original languageEnglish
Pages (from-to)2037-2040
Number of pages4
JournalEuropean Journal of Cancer
Volume34
Issue number13
DOIs
Publication statusPublished - Dec 1 1998
Externally publishedYes

Keywords

  • Bladder cancer
  • E-cadherin
  • P120
  • Prognostic marker

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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