Abnormal expression of the E-cadherin-catenin complex in dysplastic Barrett's oesophagus

John P. Seery, Konstantinos N. Syrigos, Anastasios J. Karayiannakis, Ali Valizadeh, Massimo Pignatelli

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

It is now accepted that altered E-cadherin-catenin complex expression in oesophageal cancer correlates with clinical and pathological parameters, while abnormal E-cadherin expression occurs early in Barrett's oesophagus. We evaluated immunohistochemically the expression and cellular localization of α-, β-, and γ-catenin, and E-cadherin in 5 dysplastic and 26 non- dysplastic cases of Barrett's oesophagus. Usually all three catenins were localized at the cell membrane, as was E-cadherin. A similar staining pattern for E-cadherin and the catenins was observed in all cases of non-dysplastic Barrett's syndrome. However, 60% (3/5) of cases with dysplasia showed loss of membranous β-catenin staining and diffuse cytoplasmic distribution, with predominantly nuclear localization in two cases. Membranous staining and concomitant cytoplasmic localization of E-cadherin, α-catenin and γ-catenin were seen in one case with abnormal β-catenin immunoreactivity. Our results indicate that altered subcellular distribution of β-catenin occurs frequently in dysplastic Barrett's oesophagus and possibly reflects the signalling function of this molecule.

Original languageEnglish
Pages (from-to)945-948
Number of pages4
JournalActa Oncologica
Volume38
Issue number7
DOIs
Publication statusPublished - 1999
Externally publishedYes

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Catenins
Barrett Esophagus
Cadherins
Staining and Labeling
Esophageal Neoplasms
Cell Membrane

ASJC Scopus subject areas

  • Oncology

Cite this

Abnormal expression of the E-cadherin-catenin complex in dysplastic Barrett's oesophagus. / Seery, John P.; Syrigos, Konstantinos N.; Karayiannakis, Anastasios J.; Valizadeh, Ali; Pignatelli, Massimo.

In: Acta Oncologica, Vol. 38, No. 7, 1999, p. 945-948.

Research output: Contribution to journalArticle

Seery, John P. ; Syrigos, Konstantinos N. ; Karayiannakis, Anastasios J. ; Valizadeh, Ali ; Pignatelli, Massimo. / Abnormal expression of the E-cadherin-catenin complex in dysplastic Barrett's oesophagus. In: Acta Oncologica. 1999 ; Vol. 38, No. 7. pp. 945-948.
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