Abstract
It is now accepted that altered E-cadherin-catenin complex expression in oesophageal cancer correlates with clinical and pathological parameters, while abnormal E-cadherin expression occurs early in Barrett's oesophagus. We evaluated immunohistochemically the expression and cellular localization of α-, β-, and γ-catenin, and E-cadherin in 5 dysplastic and 26 non- dysplastic cases of Barrett's oesophagus. Usually all three catenins were localized at the cell membrane, as was E-cadherin. A similar staining pattern for E-cadherin and the catenins was observed in all cases of non-dysplastic Barrett's syndrome. However, 60% (3/5) of cases with dysplasia showed loss of membranous β-catenin staining and diffuse cytoplasmic distribution, with predominantly nuclear localization in two cases. Membranous staining and concomitant cytoplasmic localization of E-cadherin, α-catenin and γ-catenin were seen in one case with abnormal β-catenin immunoreactivity. Our results indicate that altered subcellular distribution of β-catenin occurs frequently in dysplastic Barrett's oesophagus and possibly reflects the signalling function of this molecule.
| Original language | English |
|---|---|
| Pages (from-to) | 945-948 |
| Number of pages | 4 |
| Journal | Acta Oncologica |
| Volume | 38 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - 1999 |
| Externally published | Yes |
Fingerprint
ASJC Scopus subject areas
- Oncology
Cite this
Abnormal expression of the E-cadherin-catenin complex in dysplastic Barrett's oesophagus. / Seery, John P.; Syrigos, Konstantinos N.; Karayiannakis, Anastasios J.; Valizadeh, Ali; Pignatelli, Massimo.
In: Acta Oncologica, Vol. 38, No. 7, 1999, p. 945-948.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Abnormal expression of the E-cadherin-catenin complex in dysplastic Barrett's oesophagus
AU - Seery, John P.
AU - Syrigos, Konstantinos N.
AU - Karayiannakis, Anastasios J.
AU - Valizadeh, Ali
AU - Pignatelli, Massimo
PY - 1999
Y1 - 1999
N2 - It is now accepted that altered E-cadherin-catenin complex expression in oesophageal cancer correlates with clinical and pathological parameters, while abnormal E-cadherin expression occurs early in Barrett's oesophagus. We evaluated immunohistochemically the expression and cellular localization of α-, β-, and γ-catenin, and E-cadherin in 5 dysplastic and 26 non- dysplastic cases of Barrett's oesophagus. Usually all three catenins were localized at the cell membrane, as was E-cadherin. A similar staining pattern for E-cadherin and the catenins was observed in all cases of non-dysplastic Barrett's syndrome. However, 60% (3/5) of cases with dysplasia showed loss of membranous β-catenin staining and diffuse cytoplasmic distribution, with predominantly nuclear localization in two cases. Membranous staining and concomitant cytoplasmic localization of E-cadherin, α-catenin and γ-catenin were seen in one case with abnormal β-catenin immunoreactivity. Our results indicate that altered subcellular distribution of β-catenin occurs frequently in dysplastic Barrett's oesophagus and possibly reflects the signalling function of this molecule.
AB - It is now accepted that altered E-cadherin-catenin complex expression in oesophageal cancer correlates with clinical and pathological parameters, while abnormal E-cadherin expression occurs early in Barrett's oesophagus. We evaluated immunohistochemically the expression and cellular localization of α-, β-, and γ-catenin, and E-cadherin in 5 dysplastic and 26 non- dysplastic cases of Barrett's oesophagus. Usually all three catenins were localized at the cell membrane, as was E-cadherin. A similar staining pattern for E-cadherin and the catenins was observed in all cases of non-dysplastic Barrett's syndrome. However, 60% (3/5) of cases with dysplasia showed loss of membranous β-catenin staining and diffuse cytoplasmic distribution, with predominantly nuclear localization in two cases. Membranous staining and concomitant cytoplasmic localization of E-cadherin, α-catenin and γ-catenin were seen in one case with abnormal β-catenin immunoreactivity. Our results indicate that altered subcellular distribution of β-catenin occurs frequently in dysplastic Barrett's oesophagus and possibly reflects the signalling function of this molecule.
UR - http://www.scopus.com/inward/record.url?scp=0032708607&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032708607&partnerID=8YFLogxK
U2 - 10.1080/028418699432635
DO - 10.1080/028418699432635
M3 - Article
VL - 38
SP - 945
EP - 948
JO - Acta Oncologica
JF - Acta Oncologica
SN - 0284-186X
IS - 7
ER -