Abnormal expression of the E-cadherin-catenin complex in dysplastic Barrett's oesophagus

John P. Seery, Konstantinos N. Syrigos, Anastasios J. Karayiannakis, Ali Valizadeh, Massimo Pignatelli

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

It is now accepted that altered E-cadherin-catenin complex expression in oesophageal cancer correlates with clinical and pathological parameters, while abnormal E-cadherin expression occurs early in Barrett's oesophagus. We evaluated immunohistochemically the expression and cellular localization of α-, β-, and γ-catenin, and E-cadherin in 5 dysplastic and 26 non- dysplastic cases of Barrett's oesophagus. Usually all three catenins were localized at the cell membrane, as was E-cadherin. A similar staining pattern for E-cadherin and the catenins was observed in all cases of non-dysplastic Barrett's syndrome. However, 60% (3/5) of cases with dysplasia showed loss of membranous β-catenin staining and diffuse cytoplasmic distribution, with predominantly nuclear localization in two cases. Membranous staining and concomitant cytoplasmic localization of E-cadherin, α-catenin and γ-catenin were seen in one case with abnormal β-catenin immunoreactivity. Our results indicate that altered subcellular distribution of β-catenin occurs frequently in dysplastic Barrett's oesophagus and possibly reflects the signalling function of this molecule.

Original languageEnglish
Pages (from-to)945-948
Number of pages4
JournalActa Oncologica
Volume38
Issue number7
DOIs
Publication statusPublished - Dec 10 1999

    Fingerprint

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Radiology Nuclear Medicine and imaging

Cite this