Abnormal immunoreactivity of the E-cadherin-catenin complex in gastric carcinoma: Relationship with patient survival

A. Jawhari, S. Jordan, S. Poole, P. Browne, M. Pignatelli, M. J G Farthing

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Abstract

Background and Aims: The E-cadherin-catenin complex plays a critical role in the maintenance of normal tissue architecture. Mutation of any of its components is believed to result in loss of cell-cell adhesion and contribute to neoplasia. The aim of this study was to examine the expression of E- cadherin and α-, β-, and γ-catenin in gastric carcinoma and dysplasia and determine any relationship with tumor characteristics and survival. Methods: Immunoperoxidase staining of E-cadherin and α-, β-, and γ-catenin was performed using 89 gastric carcinomas, lymph node metastases, and gastric biopsy specimens from 14 patients with dysplasia and 10 healthy controls. Results: Membranous staining was observed in control biopsy specimens for all components of the complex. Up to 57% of gastric dysplasia and 90% of tumors stained abnormally for one or more components of the cadherin-catenin complex. Abnormal E-cadherin and γ-catenin staining occurred more frequently in diffuse than intestinal tumors (P <0.0005 and <0.05, respectively). No association with tumor grade or stage was found. A survival advantage was noted in intestinal and diffuse tumors retaining membranous expression of β- catenin, independent of tumor type, grade, or stage (P <0.005). Conclusions: Abnormal expression of the E-cadherin-catenin complex occurs frequently in gastric carcinoma. The close correlation with poor survival suggests that abnormal β-catenin may be a useful prognostic marker.

Original languageEnglish
Pages (from-to)46-54
Number of pages9
JournalGastroenterology
Volume112
Issue number1
Publication statusPublished - 1997
Externally publishedYes

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Catenins
Cadherins
Stomach
Carcinoma
Survival
Neoplasms
Staining and Labeling
Biopsy
Cell Adhesion
Lymph Nodes
Maintenance
Neoplasm Metastasis
Mutation

ASJC Scopus subject areas

  • Gastroenterology

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Abnormal immunoreactivity of the E-cadherin-catenin complex in gastric carcinoma : Relationship with patient survival. / Jawhari, A.; Jordan, S.; Poole, S.; Browne, P.; Pignatelli, M.; Farthing, M. J G.

In: Gastroenterology, Vol. 112, No. 1, 1997, p. 46-54.

Research output: Contribution to journalArticle

Jawhari, A, Jordan, S, Poole, S, Browne, P, Pignatelli, M & Farthing, MJG 1997, 'Abnormal immunoreactivity of the E-cadherin-catenin complex in gastric carcinoma: Relationship with patient survival', Gastroenterology, vol. 112, no. 1, pp. 46-54.
Jawhari, A. ; Jordan, S. ; Poole, S. ; Browne, P. ; Pignatelli, M. ; Farthing, M. J G. / Abnormal immunoreactivity of the E-cadherin-catenin complex in gastric carcinoma : Relationship with patient survival. In: Gastroenterology. 1997 ; Vol. 112, No. 1. pp. 46-54.
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abstract = "Background and Aims: The E-cadherin-catenin complex plays a critical role in the maintenance of normal tissue architecture. Mutation of any of its components is believed to result in loss of cell-cell adhesion and contribute to neoplasia. The aim of this study was to examine the expression of E- cadherin and α-, β-, and γ-catenin in gastric carcinoma and dysplasia and determine any relationship with tumor characteristics and survival. Methods: Immunoperoxidase staining of E-cadherin and α-, β-, and γ-catenin was performed using 89 gastric carcinomas, lymph node metastases, and gastric biopsy specimens from 14 patients with dysplasia and 10 healthy controls. Results: Membranous staining was observed in control biopsy specimens for all components of the complex. Up to 57{\%} of gastric dysplasia and 90{\%} of tumors stained abnormally for one or more components of the cadherin-catenin complex. Abnormal E-cadherin and γ-catenin staining occurred more frequently in diffuse than intestinal tumors (P <0.0005 and <0.05, respectively). No association with tumor grade or stage was found. A survival advantage was noted in intestinal and diffuse tumors retaining membranous expression of β- catenin, independent of tumor type, grade, or stage (P <0.005). Conclusions: Abnormal expression of the E-cadherin-catenin complex occurs frequently in gastric carcinoma. The close correlation with poor survival suggests that abnormal β-catenin may be a useful prognostic marker.",
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T1 - Abnormal immunoreactivity of the E-cadherin-catenin complex in gastric carcinoma

T2 - Relationship with patient survival

AU - Jawhari, A.

AU - Jordan, S.

AU - Poole, S.

AU - Browne, P.

AU - Pignatelli, M.

AU - Farthing, M. J G

PY - 1997

Y1 - 1997

N2 - Background and Aims: The E-cadherin-catenin complex plays a critical role in the maintenance of normal tissue architecture. Mutation of any of its components is believed to result in loss of cell-cell adhesion and contribute to neoplasia. The aim of this study was to examine the expression of E- cadherin and α-, β-, and γ-catenin in gastric carcinoma and dysplasia and determine any relationship with tumor characteristics and survival. Methods: Immunoperoxidase staining of E-cadherin and α-, β-, and γ-catenin was performed using 89 gastric carcinomas, lymph node metastases, and gastric biopsy specimens from 14 patients with dysplasia and 10 healthy controls. Results: Membranous staining was observed in control biopsy specimens for all components of the complex. Up to 57% of gastric dysplasia and 90% of tumors stained abnormally for one or more components of the cadherin-catenin complex. Abnormal E-cadherin and γ-catenin staining occurred more frequently in diffuse than intestinal tumors (P <0.0005 and <0.05, respectively). No association with tumor grade or stage was found. A survival advantage was noted in intestinal and diffuse tumors retaining membranous expression of β- catenin, independent of tumor type, grade, or stage (P <0.005). Conclusions: Abnormal expression of the E-cadherin-catenin complex occurs frequently in gastric carcinoma. The close correlation with poor survival suggests that abnormal β-catenin may be a useful prognostic marker.

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