Abnormal immunoreactivity of the E-cadherin/catenin (α-, β-, and γ-) complex in premalignant and malignant non-melanocytic skin tumours

Evangelia Papadavid, Massimo Pignatelli, Spyridon Zakynthinos, Thomas Krausz, Anthony C. Chu

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

E-cadherin/catenin (α-, β-, and γ-) complex plays a critical role in the control of epithelial differentiation. The aim of this study was to examine the immunoreactivity of E-cadherin and α-, β-, and γ-catenins in premalignant and malignant non-melanocytic skin tumours (NMST) and to correlate their expression with the grade of tumour differentiation, as assessed by the established histopathological criteria and by the Ki-67 index. Benign NMSTs were also studied. To investigate any possible influence of immunosuppression in the expression of E-cadherin and catenins, the study compared tumours obtained from renal transplant recipients (RTRs) and immunocompetent patients. Immunoperoxidase staining of E-cadherin and α-, β-, and γ-catenins was performed in 42 squamous cell carcinomas (SCCs) (26 from RTRs and 16 from non-RTRs), 30 lesions of Bowen's disease (11 from RTRs and 19 from non-RTRs), 11 atypical squamoproliferative lesions from RTRs, 19 actinic keratoses (9 from RTRs and 10 from non-RTRs), and 20 viral warts from RTRs. The findings of this study were as follows. Firstly, the probability of abnormal expression of E-cadherin and α-, β-, and γ-catenins increased from benign to premalignant and malignant NMSTs (p40%) Ki-67 index than in those with a low Ki-67 index (

Original languageEnglish
Pages (from-to)154-162
Number of pages9
JournalJournal of Pathology
Volume196
Issue number2
DOIs
Publication statusPublished - 2002
Externally publishedYes

Fingerprint

Catenins
Cadherins
Skin
Kidney
Neoplasms
Bowen's Disease
Actinic Keratosis
Transplant Recipients
Warts
Immunosuppression
Squamous Cell Carcinoma
Staining and Labeling

Keywords

  • Adhesion
  • Catenin
  • E-cadherin
  • Immunohistochemistry
  • Immunosuppression
  • Skin tumours
  • Squamous cell carcinoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Abnormal immunoreactivity of the E-cadherin/catenin (α-, β-, and γ-) complex in premalignant and malignant non-melanocytic skin tumours. / Papadavid, Evangelia; Pignatelli, Massimo; Zakynthinos, Spyridon; Krausz, Thomas; Chu, Anthony C.

In: Journal of Pathology, Vol. 196, No. 2, 2002, p. 154-162.

Research output: Contribution to journalArticle

Papadavid, Evangelia ; Pignatelli, Massimo ; Zakynthinos, Spyridon ; Krausz, Thomas ; Chu, Anthony C. / Abnormal immunoreactivity of the E-cadherin/catenin (α-, β-, and γ-) complex in premalignant and malignant non-melanocytic skin tumours. In: Journal of Pathology. 2002 ; Vol. 196, No. 2. pp. 154-162.
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