Actin-binding protein alpha-actinin 4 (ACTN4) is a transcriptional co-activator of RelA/p65 sub-unit of NF-kB

Vasilisa Aksenova, Lidia Turoverova, Mikhai Khotin, Karl Eric Magnusson, Eugene Tulchinsky, Gerry Melino, George P. Pinaev, Nickolai Barlev, Dmitri Tentler

Research output: Contribution to journalArticlepeer-review

23 Citations (Scopus)

Abstract

ACTN4 is an actin-binding protein that participates in cytoskeleton organisation. It resides both in the cytoplasm and nucleus and physically associates with various transcription factors. Here, we describe an effect of ACTN4 expression on transcriptional activity of the RelA/p65 subunit of NF-kB. We demonstrate that ACTN4 enhances RelA/p65-dependant expression of c-fos, MMP-3 and MMP-1 genes, but it does not affect TNC, ICAM1 and FN1 expression. Importantly, actin-binding domains of ACTN4 are not critical for the nuclear translocation and co-activation of RelA/p65-dependent transcription. Collectively, our data suggest that in the nucleus, ACTN4 functions as a selective transcriptional co-activator of RelA/p65.

Original languageEnglish
Pages (from-to)362-372
Number of pages11
JournalOncotarget
Volume4
Issue number2
DOIs
Publication statusPublished - 2013
Externally publishedYes

Keywords

  • ACTN4
  • MMP
  • RelA/p65
  • Transcription regulation

ASJC Scopus subject areas

  • Oncology

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