Acute acalculous cholecystitis in children

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16 Citations (Scopus)


Acute acalculous cholecystitis (AAC) is the inflammatory disease of the gallbladder in the absence of gallstones. AAC is estimated to represent at least 50% to 70% of all cases of acute cholecystitis during childhood. Although this pathology was originally described in critically ill or post-surgical patients, most pediatric cases have been observed during several infectious diseases. In addition to cases caused by bacterial and parasitic infections, most pediatric reports after 2000 described children developing AAC during viral illnesses (such as Epstein-Barr virus and hepatitis A virus infections). Moreover, some pediatric cases have been associated with several underlying chronic diseases and, in particular, with immune-mediated disorders. Here, we review the epidemiological aspects of pediatric AAC, and we discuss etiology, pathophysiology and clinical management, according to the cases reported in the medical literature.

Original languageEnglish
Pages (from-to)4870-4879
Number of pages10
JournalWorld Journal of Gastroenterology
Issue number43
Publication statusPublished - Nov 21 2018


  • Acute acalculous cholecystitis
  • Children
  • Viral biliary disorders

ASJC Scopus subject areas

  • Gastroenterology

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