Acute Pustular Dermatosis, Following Topical Treatment With Pimecrolimus, in a Child Affected With Atopic and Contact Hand Dermatitis

Dimitri Poddighe, Valeria Brazzelli, Amelia Licari, Gian Luigi Marseglia

Research output: Contribution to journalArticle


Atopic dermatitis is considered an important risk factor for chronic hand dermatitis, which can be seen in children too. Pimecrolimus cream 1% is approved to treat atopic dermatitis in children aged 2 years or older. In adults, this drug has been used for some clinical indications other than atopic dermatitis, such as chronic hand dermatitis. Here, we describe an adverse drug reaction in a 2-year-old child affected with atopic dermatitis, who was treated with topical pimecrolimus in order to ameliorate her concomitant hand dermatitis. The use of topical pimecrolimus led to a previously undescribed hand pustular dermatosis, being consistent with a form of pustular leukocytoclastic vasculitis, which required the permanent discontinuation of topical pimecrolimus.

Original languageEnglish
Pages (from-to)81-4
Number of pages4
JournalJournal of Pediatric Pharmacology and Therapeutics
Issue number1
Publication statusPublished - Mar 22 2016
Externally publishedYes


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