Adherence to treatment with protease inhibitors and therapeutic outcome in an unselected cohort of HIV-infected patients: A retrospective study

L. Lazzarini, M. Lanzafame, A. Polo, S. Vento, E. Concia

Research output: Contribution to journalArticle

Abstract

Objectives: A retrospective study was carried out to assess the relationship between medication adherence to protease inhibitors and therapeutic outcome in an unselected cohort of HIV infected patients. Methods: 173 patients, undergoing a triple antiretroviral treatment including a protease inhibitor, were recruited. Adherence was assessed through an antiretroviral medicine register. Results: Non-adherence was found in 26.5% of patients on indinavir, in 29% of patients on ritonavir and in 25.7% of patients on saquinavir. No immunological and clinical failure was recorded during the study. At the end of the study, the average plasmatic viremia was lower in adherent than in non-adherent patients (11,587 vs 21,258 copies/mL; p = 0.09) and particularly in AIDS patients (12,478 vs 39,713 copies/mL; p = 0.01). Virological failure occurred in 29.8% of adherent and in 48% of non-adherent patients (p = 0.75). Conclusions: These data support the relationship between adherence and therapeutic success in AIDS patients, but not in asymptomatic subjects.

Original languageEnglish
Pages (from-to)140-143
Number of pages4
JournalGiornale Italiano di Malattie Infettive
Volume6
Issue number3
Publication statusPublished - Dec 1 2000

Keywords

  • Adherence
  • Antiretroviral therapy
  • Compliance
  • HAART
  • HIV

ASJC Scopus subject areas

  • Microbiology (medical)

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