Adhesion molecules as diagnostic tools in tumor pathology

Y. Ohene-Abuakwa, M. Pignatelli

Research output: Contribution to journalReview article

35 Citations (Scopus)

Abstract

Adhesion molecules are transmembrane glycoproteins mediating cell-cell and cell extracellular matrix interactions. They control a number of fundamental biological processes including cell migration, differentiation, proliferation, and apoptosis. In the last decade there has been an increasing interest in the exploitation of these molecules as diagnostic and/or prognostic markers in tumor pathology. For example, a large number of studies have shown that loss of E-cadherin expression correlates with high tumor grade and advanced tumor stage in a number of malignancies. The analysis of adhesion molecule profile in a routine clinical setting needs further investigation in prospective multicenter studies.

Original languageEnglish
Pages (from-to)191-200
Number of pages10
JournalInternational Journal of Surgical Pathology
Volume8
Issue number3
DOIs
Publication statusPublished - Jan 1 2000

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Keywords

  • CD44
  • Cadherin
  • Cancer
  • Immunoglobulins
  • Integrins
  • Prognosis

ASJC Scopus subject areas

  • Anatomy
  • Surgery
  • Pathology and Forensic Medicine

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