Adsorption of inflammatory cytokines and endotoxin by mesoporous polymers and activated carbons

M. C. Murphy, S. Patel, G. J. Phillips, J. G. Davies, A. W. Lloyd, V. M. Gun'Ko, S. V. Mikhalovsky

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Adsorption of E. coli lipopolysaccharide (LPS) and an inflammatory cytokine TNF-α from model solutions on uncoated 'hyper-crosslinked' polystyrene polymers MN200 and MN500 and activated carbons Carboxen 1003 and Carboxen 1010 has been studied. It has been shown that TNFα can be efficiently removed by both non-functionalised MN200 and MN500 functionalised with cation exchange functional groups. On the contrary, surface chemistry of the resins is important in LPS adsorption, MN500 being significantly more efficient than MN200. Presence of mesopores in Carboxen 1003 correlates with its higher adsorption capacity towards LPS in comparison with purely microporous Carboxen 1010. It has been suggested that hydrophobic interactions play an important role in TNFα adsorption, whereas in LPS adsorption electrostatic interactions dominate the process.

Original languageEnglish
Pages (from-to)515-520
Number of pages6
JournalStudies in Surface Science and Catalysis
Volume144
Publication statusPublished - 2002
Externally publishedYes

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endotoxins
activated carbon
Endotoxins
Activated carbon
Polymers
Lipopolysaccharides
Cytokines
Adsorption
adsorption
carbon
polymers
Polystyrenes
Coulomb interactions
Surface chemistry
resins
Escherichia coli
Functional groups
Cations
polystyrene
Ion exchange

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Catalysis

Cite this

Murphy, M. C., Patel, S., Phillips, G. J., Davies, J. G., Lloyd, A. W., Gun'Ko, V. M., & Mikhalovsky, S. V. (2002). Adsorption of inflammatory cytokines and endotoxin by mesoporous polymers and activated carbons. Studies in Surface Science and Catalysis, 144, 515-520.

Adsorption of inflammatory cytokines and endotoxin by mesoporous polymers and activated carbons. / Murphy, M. C.; Patel, S.; Phillips, G. J.; Davies, J. G.; Lloyd, A. W.; Gun'Ko, V. M.; Mikhalovsky, S. V.

In: Studies in Surface Science and Catalysis, Vol. 144, 2002, p. 515-520.

Research output: Contribution to journalArticle

Murphy, MC, Patel, S, Phillips, GJ, Davies, JG, Lloyd, AW, Gun'Ko, VM & Mikhalovsky, SV 2002, 'Adsorption of inflammatory cytokines and endotoxin by mesoporous polymers and activated carbons', Studies in Surface Science and Catalysis, vol. 144, pp. 515-520.
Murphy MC, Patel S, Phillips GJ, Davies JG, Lloyd AW, Gun'Ko VM et al. Adsorption of inflammatory cytokines and endotoxin by mesoporous polymers and activated carbons. Studies in Surface Science and Catalysis. 2002;144:515-520.
Murphy, M. C. ; Patel, S. ; Phillips, G. J. ; Davies, J. G. ; Lloyd, A. W. ; Gun'Ko, V. M. ; Mikhalovsky, S. V. / Adsorption of inflammatory cytokines and endotoxin by mesoporous polymers and activated carbons. In: Studies in Surface Science and Catalysis. 2002 ; Vol. 144. pp. 515-520.
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