Adsorption of inflammatory cytokines and endotoxin by mesoporous polymers and activated carbons

M. C. Murphy, S. Patel, G. J. Phillips, J. G. Davies, A. W. Lloyd, V. M. Gun'Ko, S. V. Mikhalovsky

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)

Abstract

Adsorption of E. coli lipopolysaccharide (LPS) and an inflammatory cytokine TNF-α from model solutions on uncoated 'hyper-crosslinked' polystyrene polymers MN200 and MN500 and activated carbons Carboxen 1003 and Carboxen 1010 has been studied. It has been shown that TNFα can be efficiently removed by both non-functionalised MN200 and MN500 functionalised with cation exchange functional groups. On the contrary, surface chemistry of the resins is important in LPS adsorption, MN500 being significantly more efficient than MN200. Presence of mesopores in Carboxen 1003 correlates with its higher adsorption capacity towards LPS in comparison with purely microporous Carboxen 1010. It has been suggested that hydrophobic interactions play an important role in TNFα adsorption, whereas in LPS adsorption electrostatic interactions dominate the process.

Original languageEnglish
Pages (from-to)515-520
Number of pages6
JournalStudies in Surface Science and Catalysis
Volume144
DOIs
Publication statusPublished - Jan 1 2002

ASJC Scopus subject areas

  • Catalysis
  • Condensed Matter Physics
  • Physical and Theoretical Chemistry
  • Surfaces, Coatings and Films
  • Materials Chemistry

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