Adsorption of inflammatory cytokines and endotoxin by mesoporous polymers and activated carbons

M. C. Murphy; S. Patel; G. J. Phillips; J. G. Davies; A. W. Lloyd; V. M. Gun'Ko; S. V. Mikhalovsky

doi:10.1016/s0167-2991(02)80175-6

Adsorption of inflammatory cytokines and endotoxin by mesoporous polymers and activated carbons

M. C. Murphy, S. Patel, G. J. Phillips, J. G. Davies, A. W. Lloyd, V. M. Gun'Ko, S. V. Mikhalovsky

School of Engineering and Digital Sciences

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

Adsorption of E. coli lipopolysaccharide (LPS) and an inflammatory cytokine TNF-α from model solutions on uncoated 'hyper-crosslinked' polystyrene polymers MN200 and MN500 and activated carbons Carboxen 1003 and Carboxen 1010 has been studied. It has been shown that TNFα can be efficiently removed by both non-functionalised MN200 and MN500 functionalised with cation exchange functional groups. On the contrary, surface chemistry of the resins is important in LPS adsorption, MN500 being significantly more efficient than MN200. Presence of mesopores in Carboxen 1003 correlates with its higher adsorption capacity towards LPS in comparison with purely microporous Carboxen 1010. It has been suggested that hydrophobic interactions play an important role in TNFα adsorption, whereas in LPS adsorption electrostatic interactions dominate the process.

Original language	English
Pages (from-to)	515-520
Number of pages	6
Journal	Studies in Surface Science and Catalysis
Volume	144
DOIs	https://doi.org/10.1016/s0167-2991(02)80175-6
Publication status	Published - Jan 1 2002

ASJC Scopus subject areas

Catalysis
Condensed Matter Physics
Physical and Theoretical Chemistry
Surfaces, Coatings and Films
Materials Chemistry

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title = "Adsorption of inflammatory cytokines and endotoxin by mesoporous polymers and activated carbons",

abstract = "Adsorption of E. coli lipopolysaccharide (LPS) and an inflammatory cytokine TNF-α from model solutions on uncoated 'hyper-crosslinked' polystyrene polymers MN200 and MN500 and activated carbons Carboxen 1003 and Carboxen 1010 has been studied. It has been shown that TNFα can be efficiently removed by both non-functionalised MN200 and MN500 functionalised with cation exchange functional groups. On the contrary, surface chemistry of the resins is important in LPS adsorption, MN500 being significantly more efficient than MN200. Presence of mesopores in Carboxen 1003 correlates with its higher adsorption capacity towards LPS in comparison with purely microporous Carboxen 1010. It has been suggested that hydrophobic interactions play an important role in TNFα adsorption, whereas in LPS adsorption electrostatic interactions dominate the process.",

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AU - Murphy, M. C.

AU - Patel, S.

AU - Phillips, G. J.

AU - Davies, J. G.

AU - Lloyd, A. W.

AU - Gun'Ko, V. M.

AU - Mikhalovsky, S. V.

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AB - Adsorption of E. coli lipopolysaccharide (LPS) and an inflammatory cytokine TNF-α from model solutions on uncoated 'hyper-crosslinked' polystyrene polymers MN200 and MN500 and activated carbons Carboxen 1003 and Carboxen 1010 has been studied. It has been shown that TNFα can be efficiently removed by both non-functionalised MN200 and MN500 functionalised with cation exchange functional groups. On the contrary, surface chemistry of the resins is important in LPS adsorption, MN500 being significantly more efficient than MN200. Presence of mesopores in Carboxen 1003 correlates with its higher adsorption capacity towards LPS in comparison with purely microporous Carboxen 1010. It has been suggested that hydrophobic interactions play an important role in TNFα adsorption, whereas in LPS adsorption electrostatic interactions dominate the process.

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