Abstract
Adsorption of E. coli lipopolysaccharide (LPS) and an inflammatory cytokine TNF-α from model solutions on uncoated 'hyper-crosslinked' polystyrene polymers MN200 and MN500 and activated carbons Carboxen 1003 and Carboxen 1010 has been studied. It has been shown that TNFα can be efficiently removed by both non-functionalised MN200 and MN500 functionalised with cation exchange functional groups. On the contrary, surface chemistry of the resins is important in LPS adsorption, MN500 being significantly more efficient than MN200. Presence of mesopores in Carboxen 1003 correlates with its higher adsorption capacity towards LPS in comparison with purely microporous Carboxen 1010. It has been suggested that hydrophobic interactions play an important role in TNFα adsorption, whereas in LPS adsorption electrostatic interactions dominate the process.
| Original language | English |
|---|---|
| Pages (from-to) | 515-520 |
| Number of pages | 6 |
| Journal | Studies in Surface Science and Catalysis |
| Volume | 144 |
| Publication status | Published - 2002 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Physical and Theoretical Chemistry
- Catalysis
Cite this
Adsorption of inflammatory cytokines and endotoxin by mesoporous polymers and activated carbons. / Murphy, M. C.; Patel, S.; Phillips, G. J.; Davies, J. G.; Lloyd, A. W.; Gun'Ko, V. M.; Mikhalovsky, S. V.
In: Studies in Surface Science and Catalysis, Vol. 144, 2002, p. 515-520.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Adsorption of inflammatory cytokines and endotoxin by mesoporous polymers and activated carbons
AU - Murphy, M. C.
AU - Patel, S.
AU - Phillips, G. J.
AU - Davies, J. G.
AU - Lloyd, A. W.
AU - Gun'Ko, V. M.
AU - Mikhalovsky, S. V.
PY - 2002
Y1 - 2002
N2 - Adsorption of E. coli lipopolysaccharide (LPS) and an inflammatory cytokine TNF-α from model solutions on uncoated 'hyper-crosslinked' polystyrene polymers MN200 and MN500 and activated carbons Carboxen 1003 and Carboxen 1010 has been studied. It has been shown that TNFα can be efficiently removed by both non-functionalised MN200 and MN500 functionalised with cation exchange functional groups. On the contrary, surface chemistry of the resins is important in LPS adsorption, MN500 being significantly more efficient than MN200. Presence of mesopores in Carboxen 1003 correlates with its higher adsorption capacity towards LPS in comparison with purely microporous Carboxen 1010. It has been suggested that hydrophobic interactions play an important role in TNFα adsorption, whereas in LPS adsorption electrostatic interactions dominate the process.
AB - Adsorption of E. coli lipopolysaccharide (LPS) and an inflammatory cytokine TNF-α from model solutions on uncoated 'hyper-crosslinked' polystyrene polymers MN200 and MN500 and activated carbons Carboxen 1003 and Carboxen 1010 has been studied. It has been shown that TNFα can be efficiently removed by both non-functionalised MN200 and MN500 functionalised with cation exchange functional groups. On the contrary, surface chemistry of the resins is important in LPS adsorption, MN500 being significantly more efficient than MN200. Presence of mesopores in Carboxen 1003 correlates with its higher adsorption capacity towards LPS in comparison with purely microporous Carboxen 1010. It has been suggested that hydrophobic interactions play an important role in TNFα adsorption, whereas in LPS adsorption electrostatic interactions dominate the process.
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M3 - Article
VL - 144
SP - 515
EP - 520
JO - Studies in Surface Science and Catalysis
JF - Studies in Surface Science and Catalysis
SN - 0167-2991
ER -