Abstract
An efficient base-promoted 3-alkylation of 3,5-dichloro-2(1H)-pyrazinones with various malonate esters is described. The method constitutes a simple example of a C-C bond forming process at the 3-position of the pyrazinone core allowing to attain 3-substituted pyrazinones in good to high yields. 3-Alkylation of 3,5-dichloro-2(1H)-pyrazinones with acetoacetic ester was accompanied by further retro-Claisen fragmentation.
Original language | English |
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Pages (from-to) | 4676-4678 |
Number of pages | 3 |
Journal | Tetrahedron Letters |
Volume | 53 |
Issue number | 35 |
DOIs | |
Publication status | Published - Aug 29 2012 |
Externally published | Yes |
Keywords
- 3,5-Dichloro-2(1H)-pyrazinones
- Acetoacetic ester
- Heterocycles
- Malonate ester
ASJC Scopus subject areas
- Biochemistry
- Organic Chemistry
- Drug Discovery