AllergoOncology: Microbiota in allergy and cancer—A European Academy for Allergy and Clinical Immunology position paper

Eva Untersmayr, Heather J. Bax, Christoph Bergmann, Rodolfo Bianchini, Wendy Cozen, Hannah J. Gould, Karin Hartmann, Debra H. Josephs, Francesca Levi-Schaffer, Manuel L. Penichet, Liam O'Mahony, Aurelie Poli, Frank A. Redegeld, Franziska Roth-Walter, Michelle C. Turner, Luca Vangelista, Sophia N. Karagiannis, Erika Jensen-Jarolim

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The microbiota can play important roles in the development of human immunity and the establishment of immune homeostasis. Lifestyle factors including diet, hygiene, and exposure to viruses or bacteria, and medical interventions with antibiotics or anti-ulcer medications, regulate phylogenetic variability and the quality of cross talk between innate and adaptive immune cells via mucosal and skin epithelia. More recently, microbiota and their composition have been linked to protective effects for health. Imbalance, however, has been linked to immune-related diseases such as allergy and cancer, characterized by impaired, or exaggerated immune tolerance, respectively. In this AllergoOncology position paper, we focus on the increasing evidence defining the microbiota composition as a key determinant of immunity and immune tolerance, linked to the risk for the development of allergic and malignant diseases. We discuss novel insights into the role of microbiota in disease and patient responses to treatments in cancer and in allergy. These may highlight opportunities to improve patient outcomes with medical interventions supported through a restored microbiome.

Original languageEnglish
Pages (from-to)1037-1051
Number of pages15
JournalAllergy: European Journal of Allergy and Clinical Immunology
Volume74
Issue number6
DOIs
Publication statusPublished - Jun 2019

Keywords

  • allergy
  • cancer
  • hygiene hypothesis
  • microbiota
  • oncoimmunology

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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  • Cite this

    Untersmayr, E., Bax, H. J., Bergmann, C., Bianchini, R., Cozen, W., Gould, H. J., Hartmann, K., Josephs, D. H., Levi-Schaffer, F., Penichet, M. L., O'Mahony, L., Poli, A., Redegeld, F. A., Roth-Walter, F., Turner, M. C., Vangelista, L., Karagiannis, S. N., & Jensen-Jarolim, E. (2019). AllergoOncology: Microbiota in allergy and cancer—A European Academy for Allergy and Clinical Immunology position paper. Allergy: European Journal of Allergy and Clinical Immunology, 74(6), 1037-1051. https://doi.org/10.1111/all.13718