AllergoOncology

Microbiota in allergy and cancer—A European Academy for Allergy and Clinical Immunology position paper

Eva Untersmayr, Heather J. Bax, Christoph Bergmann, Rodolfo Bianchini, Wendy Cozen, Hannah J. Gould, Karin Hartmann, Debra H. Josephs, Francesca Levi-Schaffer, Manuel L. Penichet, Liam O'Mahony, Aurelie Poli, Frank A. Redegeld, Franziska Roth-Walter, Michelle C. Turner, Luca Vangelista, Sophia N. Karagiannis, Erika Jensen-Jarolim

Research output: Contribution to journalArticle

Abstract

The microbiota can play important roles in the development of human immunity and the establishment of immune homeostasis. Lifestyle factors including diet, hygiene, and exposure to viruses or bacteria, and medical interventions with antibiotics or anti-ulcer medications, regulate phylogenetic variability and the quality of cross talk between innate and adaptive immune cells via mucosal and skin epithelia. More recently, microbiota and their composition have been linked to protective effects for health. Imbalance, however, has been linked to immune-related diseases such as allergy and cancer, characterized by impaired, or exaggerated immune tolerance, respectively. In this AllergoOncology position paper, we focus on the increasing evidence defining the microbiota composition as a key determinant of immunity and immune tolerance, linked to the risk for the development of allergic and malignant diseases. We discuss novel insights into the role of microbiota in disease and patient responses to treatments in cancer and in allergy. These may highlight opportunities to improve patient outcomes with medical interventions supported through a restored microbiome.

Original languageEnglish
JournalAllergy: European Journal of Allergy and Clinical Immunology
DOIs
Publication statusPublished - Jan 1 2019

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Microbiota
Allergy and Immunology
Hypersensitivity
Immune Tolerance
Immunity
Immune System Diseases
Human Development
Hygiene
Ulcer
Life Style
Neoplasms
Homeostasis
Epithelium
Anti-Bacterial Agents
Diet
Viruses
Bacteria
Skin
Health

Keywords

  • allergy
  • cancer
  • hygiene hypothesis
  • microbiota
  • oncoimmunology

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

AllergoOncology : Microbiota in allergy and cancer—A European Academy for Allergy and Clinical Immunology position paper. / Untersmayr, Eva; Bax, Heather J.; Bergmann, Christoph; Bianchini, Rodolfo; Cozen, Wendy; Gould, Hannah J.; Hartmann, Karin; Josephs, Debra H.; Levi-Schaffer, Francesca; Penichet, Manuel L.; O'Mahony, Liam; Poli, Aurelie; Redegeld, Frank A.; Roth-Walter, Franziska; Turner, Michelle C.; Vangelista, Luca; Karagiannis, Sophia N.; Jensen-Jarolim, Erika.

In: Allergy: European Journal of Allergy and Clinical Immunology, 01.01.2019.

Research output: Contribution to journalArticle

Untersmayr, E, Bax, HJ, Bergmann, C, Bianchini, R, Cozen, W, Gould, HJ, Hartmann, K, Josephs, DH, Levi-Schaffer, F, Penichet, ML, O'Mahony, L, Poli, A, Redegeld, FA, Roth-Walter, F, Turner, MC, Vangelista, L, Karagiannis, SN & Jensen-Jarolim, E 2019, 'AllergoOncology: Microbiota in allergy and cancer—A European Academy for Allergy and Clinical Immunology position paper', Allergy: European Journal of Allergy and Clinical Immunology. https://doi.org/10.1111/all.13718
Untersmayr, Eva ; Bax, Heather J. ; Bergmann, Christoph ; Bianchini, Rodolfo ; Cozen, Wendy ; Gould, Hannah J. ; Hartmann, Karin ; Josephs, Debra H. ; Levi-Schaffer, Francesca ; Penichet, Manuel L. ; O'Mahony, Liam ; Poli, Aurelie ; Redegeld, Frank A. ; Roth-Walter, Franziska ; Turner, Michelle C. ; Vangelista, Luca ; Karagiannis, Sophia N. ; Jensen-Jarolim, Erika. / AllergoOncology : Microbiota in allergy and cancer—A European Academy for Allergy and Clinical Immunology position paper. In: Allergy: European Journal of Allergy and Clinical Immunology. 2019.
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